2.3.1.71: glycine N-benzoyltransferase
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For detailed information about glycine N-benzoyltransferase, go to the full flat file.
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Synonyms
aralkyl-CoA:glycine N-acyltransferase, benzoyl CoA-amino acid N-acyltransferase, benzoyl-CoA:glycine N-acyltransferase, benzoyltransferase, glycine, GlyAT, glycine N-acyltransferase, GNAT
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medicine
isoform Glyat expression is suppressed in all hepatocellular carcinomas, but not in other liver diseases. Glyat repression in cancerous cells in the liver is controlled at the transcriptional level
medicine
in a small cohort of South African Caucasian individuals, the two most prominent GLYAT haplotypes in all populations analysed, are S156 (70%) and T17S156 (20%). The S156C199 and S156H131 haplotypes, which have a negative effect on the enzyme activity of a recombinant human GLYAT, are detected at very low frequencies. An additional Q61L SNP occurring at a high frequency (12%) was detected
medicine
study to investigate 4-aminobenzoic acid as an alternative glycine conjugation probe. All of the participants were homozygous for increased enzyme activity, but excretion of product 4-amino-N-benzoylglycine varies significantly (16-56%, hippurate ratio)