2.3.1.80: cysteine-S-conjugate N-acetyltransferase
This is an abbreviated version!
For detailed information about cysteine-S-conjugate N-acetyltransferase, go to the full flat file.
Reaction
Synonyms
acetyltransferase, cysteine S-conjugate N-, NAT8
ECTree
2.3.1.80 cysteine-S-conjugate N-acetyltransferaseAdvanced search results
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Substrates Products on EC 2.3.1.80 - cysteine-S-conjugate N-acetyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + an S-substituted L-cysteine
CoA + an S-substituted N-acetyl-L-cysteine
-
final reaction of mercapturic biosynthesis
-
-
?
acetyl-CoA + leukotriene E4
CoA + N-acetyl-leukotriene E4
about 1% of the activity with S-benzyl-L-cysteine
-
-
?
acetyl-CoA + O-benzyl-L-serine
CoA + N-acetyl-O-benzyl-L-cysteine
-
-
-
-
?
acetyl-CoA + S-1-menaphthyl-L-cysteine
CoA + N-acetyl-S-1-menaphthyl-L-cysteine
-
-
-
?
acetyl-CoA + S-4-nitrobenzyl-L-cysteine
CoA + N-acetyl-S-4-nitrobenzyl-L-cysteine
-
-
-
?
acetyl-CoA + S-butyl-L-cysteine
CoA + N-acetyl-S-butyl-L-cysteine
-
-
-
-
?
acetyl-CoA + S-ethyl-L-cysteine
CoA + N-acetyl-S-ethyl-L-cysteine
-
-
-
-
?
acetyl-CoA + S-propyl-L-cysteine
CoA + N-acetyl-S-propyl-L-cysteine
-
-
-
-
?
S-(1,2,3,4,4-pentachloro-butadienyl)-L-cysteine + acetyl-CoA
N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine + CoA
acetyl-CoA + S-benzyl-L-cysteine
CoA + N-acetyl-S-benzyl-L-cysteine
-
-
-
?
acetyl-CoA + S-benzyl-L-cysteine
CoA + N-acetyl-S-benzyl-L-cysteine
-
best substrate
-
-
?
S-(1,2,3,4,4-pentachloro-butadienyl)-L-cysteine + acetyl-CoA
N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine + CoA
-
-
-
-
?
S-(1,2,3,4,4-pentachloro-butadienyl)-L-cysteine + acetyl-CoA
N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine + CoA
-
-
-
-
?
additional information
?
-
besides S-benzyl-L-cysteine and leukotriene E4, enzyme is inactive on physiological amines or amino acids L-aspartate, L-lysine, L-cystine, L-methionine, L-ethionine, L-cystathionine, or L-phenylalanine, L-tyrosine, and L-tryptophan
-
-
?
additional information
?
-
-
no substrate: aniline, o-aminobenzoate, D-cysteine, L-methionine, L-leucine, L-phenylalanine, L-glutamate
-
-
?
additional information
?
-
-
comparison of haloalkene-derived cysteine S-conjugates
-
-
?
