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2.3.1.81: aminoglycoside 3-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 3-N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.81

Reaction

acetyl-CoA
+
a 2-deoxystreptamine antibiotic
=
CoA
 +
N3-acetyl-2-deoxystreptamine antibiotic

Synonyms

3'-aminoglycoside acetyltransferase, 3-N-acetyltransferase, 3-N-aminoglycoside acetyltransferase, AAC, AAC (3)-IIIb, AAC(3), AAC(3)-Id, AAC(3)-Ig acetyltransferase, Aac(3)-IIIb, AAC(3)-IV, AAC(3)-XI, AAC(6')-APH(2''), AAC-IIIb, AAC-VIa, aac3-Ia, AAC3-IV aminoglycoside acetyltransferase, AacC-A7 acetyltransferase, aminoglycoside 3-acetyltransferase, aminoglycoside 3-acetyltransferase-IIIb, aminoglycoside 3-N-acetyltransferase, aminoglycoside 3-N-acetyltransferase type XI, aminoglycoside acetyltransferase, aminoglycoside acetytransferase, aminoglycoside N(3)-acetyltransferase III, aminoglycoside N3-acetyltransferase, aminoglycoside N3-acetyltransferase-IIIb, aminoglycoside N3-acetyltransferase-VIa, Eis, Eis2, Enhanced in Intracellular Survival, More, RbmI

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.81 aminoglycoside 3-N-acetyltransferase

Inhibitors

Inhibitors on EC 2.3.1.81 - aminoglycoside 3-N-acetyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-(dimethylamino)propylamine
-
0.5 mM, 30% residual activity
acetyltobramycin
-
-
amikacin
-
-
butyryl-CoA
-
dead-end inhibition pattern
CoA
-
product inhibition
EDTA
-
above 0.5 mM
gentamicin C1a
-
substrate inhibition
kanamycin A
-
substrate inhibition
kanamycin B
-
substrate inhibition
N-(2-naphthyl)-N-methyl-2,3-dioxo-1,2,3,4-tetrahydro-6-quinoxalinesulfonamide
lacks anti-Mycobacterium tuberculosis activity in the absence of kanamycin in either tested strain
-
N-(3-methoxyphenyl)-N-methyl-2,3-dioxo-1,2,3,4-tetrahydro-6-quinoxalinesulfonamide
inhibitor completely overcomes kanamycin resistance in Mycobacterium tuberculosis K204, lacks anti-Mycobacterium tuberculosis activity in the absence of kanamycin in either tested strain
N-cyclohexyl-3-(3-dimethylamino-propylamino)-propionamide
-
0.5 mM, 77% inhibition
N-[2-(3,4-dimethoxyphenyl)-ethyl]-3-(3-dimethylamino-propylamino)-propionamide
-
0.5 mM, 63% inhibition
N3-Acetyltobramycin
-
product inhibition
neomycin
-
-
ribostamycin
tobramycin
-
substrate inhibition
additional information
-