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2.3.1.81: aminoglycoside 3-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 3-N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.81

Reaction

acetyl-CoA
+
a 2-deoxystreptamine antibiotic
=
CoA
 +
N3-acetyl-2-deoxystreptamine antibiotic

Synonyms

3'-aminoglycoside acetyltransferase, 3-N-acetyltransferase, 3-N-aminoglycoside acetyltransferase, AAC, AAC (3)-IIIb, AAC(3), AAC(3)-Id, AAC(3)-Ig acetyltransferase, Aac(3)-IIIb, AAC(3)-IV, AAC(3)-XI, AAC(6')-APH(2''), AAC-IIIb, AAC-VIa, aac3-Ia, AAC3-IV aminoglycoside acetyltransferase, AacC-A7 acetyltransferase, aminoglycoside 3-acetyltransferase, aminoglycoside 3-acetyltransferase-IIIb, aminoglycoside 3-N-acetyltransferase, aminoglycoside 3-N-acetyltransferase type XI, aminoglycoside acetyltransferase, aminoglycoside acetytransferase, aminoglycoside N(3)-acetyltransferase III, aminoglycoside N3-acetyltransferase, aminoglycoside N3-acetyltransferase-IIIb, aminoglycoside N3-acetyltransferase-VIa, Eis, Eis2, Enhanced in Intracellular Survival, More, RbmI

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.81 aminoglycoside 3-N-acetyltransferase

KM Value

KM Value on EC 2.3.1.81 - aminoglycoside 3-N-acetyltransferase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0013 - 0.17
acetyl-CoA
0.00096 - 11.07
amikacin
0.00067
apramycin
in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C
0.237
butirosin
in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C
1.16
butyryl-CoA
in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C
0.0092
dibekacin
0.0029 - 0.0189
gentamicin
0.002 - 0.066
gentamicin C1
0.00012
gentamicin C1a
-
-
0.003
gentamicin C2
-
pH 7.6, 25°C
0.00097
gentamycin
in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C
0.002 - 0.238
kanamycin A
0.0026 - 0.0802
kanamycin B
0.0036
lividomycin A
-
pH 7.6, 25°C
0.234 - 0.477
malonyl-CoA
0.0886
n-propionyl-CoA
-
cosubstrate kanamycin A, pH 7.6, 25°C
0.00036
neomycin
in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C
0.0012 - 0.0148
neomycin B
0.042
netilmicin
in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C
0.00015 - 0.0033
paromomycin
0.499
propionyl-CoA
in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C
0.0023 - 0.0031
ribostamycin
0.00057 - 0.015
sisomicin
0.00033 - 0.0015
sisomycin
0.0013 - 0.106
tobramycin
additional information
additional information
-