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2.3.1.82: aminoglycoside 6'-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 6'-N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.82

Reaction

acetyl-CoA
+
kanamycin-B
=
CoA
 +
N6'-acetylkanamycin-B

Synonyms

6'-acetyltransferase-Im, 6'-N-acetyltransferase type Ib, AAC, aac(3)-Ib/aac(6')-Ib, AAC(3)-Ib/AAC(6')-Ib', AAC(6'), AAC(6')-I, AAC(6')-Iaf, AAC(6')-IaI, AAC(6')-Iaj, AAC(6')-Ian, AAC(6')-Ib, AAC(6')-Ib-cr, AAC(6')-Ie, AAC(6')-Ie/APH(2")-Ia, AAC(6')-Ie/APH(2'')-Ia, AAC(6')-Ie/APH(2')-Ia, AAC(6')-Ig, AAC(6')-Ih, AAC(6')-Ii, AAC(6')-Im, AAC(6')-Isa, AAC(6')-Iy, AAC(6')-Iz acetyltransferase, AAC(6)-Iak, aac(6)-Ib, AAC3-I, aacA-aphD, acetyltransferase, aminoglycoside 6'-N-, acetyltransferase, kanamycin, acetyltransferase-6'-aminoglycoside phosphotransferase-2", aminoglycoside (3) acetyltransferase AAC(3)-Ia, aminoglycoside 3-N-acetyltransferase/aminoglycoside 6'-N-acetyltransferase fusion protein, aminoglycoside 6'-acetyltransferase-Ie, aminoglycoside 6'-N-acetyltransferase, aminoglycoside 6'-N-acetyltransferase Ib, aminoglycoside 6'-N-acetyltransferase type Ib, aminoglycoside 6'-N-acetyltransferase type Ii, aminoglycoside 6-N-acetyltransferase, aminoglycoside acetyltransferase, aminoglycoside acetyltransferase eis, aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2')-Ia, aminoglycoside N(6')-acetyltransferase type 1, aminoglycoside N-6'-acetyltransferase, aminoglycoside N-6'-acetyltransferase Ii, aminoglycoside N-acetyltransferase, aminoglycoside-6'-acetyltransferase, aminoglycoside-6'-N-acetyltransferase, aminoglycoside-6-N-acetyltransferase, ANT(3'')-Ii/AAC(6')-IId, EC 2.3.1.55, meta-AAC0020

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.82 aminoglycoside 6'-N-acetyltransferase

Substrates Products

Substrates Products on EC 2.3.1.82 - aminoglycoside 6'-N-acetyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + 2'-N-ethyl netilmicin
CoA + N6'-acetyl-2'-N-ethylnetilmicin
show the reaction diagram
-
-
-
?
acetyl-CoA + 2'-N-ethylnetilmicin
CoA + N6'-acetyl-2'-N-ethylnetilmicin
show the reaction diagram
acetyl-CoA + amikacin
?
show the reaction diagram
-
-
-
-
?
acetyl-CoA + amikacin
CoA + 6'-N-acetylamikacin
show the reaction diagram
acetyl-CoA + amikacin
CoA + N6'-acetylamikacin
show the reaction diagram
acetyl-CoA + aminoglycoside
CoA + 6'-N-acetylaminoglycoside
show the reaction diagram
-
-
-
-
?
acetyl-CoA + arbekacin
CoA + 6'-N-acetylarbekacin
show the reaction diagram
acetyl-CoA + arbekacin
CoA + N6'-acetylarbekacin
show the reaction diagram
acetyl-CoA + butirosin
CoA + N6'-acetylbutirosin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + butirosin A
CoA + 6'-N-acetyl-butirosin A
show the reaction diagram
acetyl-CoA + ciprofloxacin
CoA + N4'-acetylnorfloxacin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + dibekacin
CoA + 6'-N-acetyldibekacin
show the reaction diagram
acetyl-CoA + dibekacin
CoA + N6'-acetyldibekacin
show the reaction diagram
acetyl-CoA + fortimicin A
CoA + N6'-acetylfortimicin A
show the reaction diagram
-
-
-
-
?
acetyl-CoA + gentamicin
CoA + 6'-N-acetylgentamicin
show the reaction diagram
acetyl-CoA + gentamicin
CoA + N6'-acetylgentamicin
show the reaction diagram
acetyl-CoA + gentamicin B
CoA + N6'-acetylgentamicin B
show the reaction diagram
-
-
-
-
?
acetyl-CoA + gentamicin C
CoA + N6'-acetylgentamicin C
show the reaction diagram
acetyl-CoA + gentamicin C1
CoA + N6'-acetylgentamicin C1
show the reaction diagram
-
the AAC(6')-Ib protein is unable to efficiently modify gentamicin C1, 1.7% relative activity to sisomicin, however it is capable of modifying amikacin, 65.5% relative activity to sisomycin. The mutant enzyme AAC(6')-Ib L119S shows a 2.8fold increase in acetylation of gentamicin C1, but a 8.7fold reduction in the ability to modify amikacin. The AAC(6')-IIa protein modifies gentamicin C1 at 10.1% relative activity to sisomicin, however it shows low activity towards amikacin, 4.1% activity relative to sisomycin. The mutation AAC(6')-IIa S119L results in a 4.8fold reduction in the acetylation of gentamicin C1, but causes an 2fold increase in the ability to modify amikacin
-
-
?
acetyl-CoA + gentamicin C1a
CoA + N6'-acetylgentamicin C1a
show the reaction diagram
acetyl-CoA + gentamicin C2
CoA + N6'-acetylgentgamicin C2
show the reaction diagram
-
poor substrate, not gentamicin A and C1
-
-
?
acetyl-CoA + gentamycin
CoA + ?
show the reaction diagram
-
-
-
?
acetyl-CoA + histone
CoA + ?
show the reaction diagram
a mixture of calf histones enriched in H3 and H4
-
-
?
acetyl-CoA + human histone H3 peptide containing a C-terminal cysteine residue
CoA + ?
show the reaction diagram
-
-
-
-
?
acetyl-CoA + hybrimycin A1
CoA + N6'-acetylhybrimycin A1
show the reaction diagram
-
-
-
-
?
acetyl-CoA + hybrimycin A2
CoA + N6'-acetylhybrimycin A2
show the reaction diagram
-
-
-
-
?
acetyl-CoA + hybrimycin A3
CoA + N6'-acetylhybrimycin A3
show the reaction diagram
-
-
-
-
?
acetyl-CoA + hybrimycin B1
CoA + N6'-acetylhybrimycin B1
show the reaction diagram
-
-
-
-
?
acetyl-CoA + hybrimycin B2
CoA + N6'-acetylhybrimycin B2
show the reaction diagram
-
-
-
-
?
acetyl-CoA + hybrimycin B3
CoA + N6'-acetylhybrimycin B3
show the reaction diagram
-
-
-
-
?
acetyl-CoA + isepamicin
CoA + 6'-N-acetylisepamicin
show the reaction diagram
acetyl-CoA + isepamicin
CoA + N6'-acetylisepamicin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + istamycin-B
CoA + N6'-acetylistamycin-B
show the reaction diagram
-
-
-
-
?
acetyl-CoA + kanamycin
CoA + 6'-N-acetylkanamycin
show the reaction diagram
acetyl-CoA + kanamycin
CoA + N6'-acetylkanamycin
show the reaction diagram
acetyl-CoA + kanamycin A
CoA + N6'-acetylkanamycin A
show the reaction diagram
acetyl-CoA + kanamycin B
CoA + N6'-acetylkanamycin B
show the reaction diagram
acetyl-CoA + kanamycin C
CoA + N6'-acetylkanamycin C
show the reaction diagram
-
-
-
?
acetyl-CoA + lividomycin A
CoA + O6'-acetyllividomycin A
show the reaction diagram
-
-
-
?
acetyl-CoA + micromomicin
CoA + N6'-acetylmicromomicin
show the reaction diagram
acetyl-CoA + myelin basic protein
CoA + ?
show the reaction diagram
-
-
-
?
acetyl-CoA + neamine
CoA + 6'-N-acetylneamine
show the reaction diagram
acetyl-CoA + neamine
CoA + N6'-acetylneamine
show the reaction diagram
acetyl-CoA + nebramycin factor 4
CoA + N6'-acetylnebramycin factor 4
show the reaction diagram
-
no activity with factor 2
-
-
?
acetyl-CoA + nebramycin factor 6
CoA + N6'-acetylnebramycin factor 6
show the reaction diagram
-
no activity with factor 2
-
-
?
acetyl-CoA + neomycin
CoA + 6'-N-acetylneomycin
show the reaction diagram
acetyl-CoA + neomycin
CoA + N6'-acetylneomycin
show the reaction diagram
acetyl-CoA + neomycin A
CoA + N6'-acetylneomycin A
show the reaction diagram
-
-
-
-
?
acetyl-CoA + neomycin B
CoA + ?
show the reaction diagram
-
-
-
?
acetyl-CoA + neomycin B
CoA + N6'-acetylneomycin B
show the reaction diagram
acetyl-CoA + neomycin C
CoA + 6'-N-acetylneomycin C
show the reaction diagram
acetyl-CoA + neomycin C
CoA + N6'-acetylneomycin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + neomycin C
CoA + N6'-acetylneomycin C
show the reaction diagram
acetyl-CoA + netilmicin
CoA + 6'-N-acetylnetilmicin
show the reaction diagram
acetyl-CoA + netilmicin
CoA + N6'-acetylnetilmicin
show the reaction diagram
acetyl-CoA + norfloxacin
CoA + N4'-acetylnorfloxacin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + paromomycin
CoA + O6'-acetylparomomycin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + poly-L-Lys
CoA + ?
show the reaction diagram
-
-
-
?
acetyl-CoA + ribostamycin
CoA + 6'-N-acetylribostamycin
show the reaction diagram
acetyl-CoA + ribostamycin
CoA + N6'-acetylribostamycin
show the reaction diagram
acetyl-CoA + ribostamycin
CoA + N6'acetylribostamycin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + sisomicin
CoA + 6'-N-acetylsisomicin
show the reaction diagram
acetyl-CoA + sisomicin
CoA + N6'-acetylsisomicin
show the reaction diagram
acetyl-CoA + tobramicin
CoA + 6'-N-acetyltobramicin
show the reaction diagram
acetyl-CoA + tobramicin
CoA + N6'-acetyltobramicin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + tobramycin
CoA + 6'-N-acetyltobramycin
show the reaction diagram
acetyl-CoA + tobramycin
CoA + N6'-acetyltobramycin
show the reaction diagram
butyryl-CoA + tobramycin
CoA + N6'-butyryltobramycin
show the reaction diagram
-
-
-
-
?
malonyl-CoA + sisomycin
CoA + ?
show the reaction diagram
-
-
-
?
malonyl-CoA + tobramycin
CoA + N6'-malonyltobramycin
show the reaction diagram
-
-
-
-
?
n-butyryl-CoA + sisomycin
CoA + ?
show the reaction diagram
-
-
-
?
n-propionyl-CoA + sisomycin
CoA + ?
show the reaction diagram
-
-
-
?
propionyl-CoA + kanamycin A
CoA + N6'-propionylkanamycin A
show the reaction diagram
-
-
-
-
?
propionyl-CoA + tobramycin
CoA + N6'-propionyltobramycin
show the reaction diagram
-
tobramycin exhibits a rapid, tobramycin-independent rate of hydrolysis that is linearly proportional to enzyme
-
-
?
additional information
?
-