2.3.1.85: fatty-acid synthase system
This is an abbreviated version!
For detailed information about fatty-acid synthase system, go to the full flat file.
Word Map on EC 2.3.1.85
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2.3.1.85
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mycobacterium
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tuberculosis
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mycolic
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lipogenic
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enoyl
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fasciclin
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cerulenin
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beta-ketoacyl-acyl
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malonyl-coa
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triclosan
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isoniazid
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transacylase
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enoyl-acyl
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beta-ketoacyl
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thiolactomycin
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malonyl-acp
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condensing
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acyl-acps
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malonyl
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srebp-1c
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fabgs
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medicine
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apicoplast
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boutons
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phosphopantetheinylation
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4'-phosphopantetheine
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ketoacyl
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antituberculous
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thiacetazone
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nutrition
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analysis
- 2.3.1.85
- mycobacterium
- tuberculosis
-
mycolic
-
lipogenic
-
enoyl
-
fasciclin
- cerulenin
-
beta-ketoacyl-acyl
- malonyl-coa
- triclosan
- isoniazid
-
transacylase
-
enoyl-acyl
-
beta-ketoacyl
- thiolactomycin
- malonyl-acp
-
condensing
- acyl-acps
-
malonyl
- srebp-1c
-
fabgs
- medicine
- apicoplast
-
boutons
-
phosphopantetheinylation
- 4'-phosphopantetheine
-
ketoacyl
-
antituberculous
- thiacetazone
- nutrition
- analysis
Reaction
+ 7 malonyl-CoA + 14 NADPH + 14 H+ = + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
Synonyms
F09E10.3 protein, FAS, FAS-II, FASI, FASII, FASN, fatty acid synthase, fatty acid synthase I, fatty acid synthase II, fatty acid synthase type 2, fatty-acid synthase, type 2 dissociative FAS, type 2 fatty acid synthase, type II fatty acid synthase, yeast fatty acid synthase
ECTree
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Application
Application on EC 2.3.1.85 - fatty-acid synthase system
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analysis
medicine
nutrition
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animals fed with semipurified diets containing either 1% w/w corn oil or 10% each of beef tallow, corn oil, perilla oil, and fish oil. Enzyme activity is reduced in the polyunsaturated fat-fed group in the order of fish oil, perilla oil, and corn oil
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targeted liquid chromatography-mass spectroscopy method to directly measure endogenous levels of malonyl-CoA to drive a drug development structure-activity relationship screening cascade. The assay is amenable to multiplexing cellular endpoints, has a typical Z' of >0.6, and has high reproducibility of EC50 values
analysis
simple mass spectrometry-based assay that affords monitoring of FASN activity and its product specificity. Purified FASN is incubated with 13C-labeled malonyl-CoA, acetyl-CoA, and NADPH, at defined time points the reaction mixture is spiked with an internal non-esterified palmitic acid standard and extracted, and the extract is analyzed directly, without vacuum evaporation and chemical derivatization, by direct-infusion high-resolution mass spectrometry in negative ion mode. The assay supports essentially noise-free detection and absolute quantification of de novo synthetized 13C-labeled non-esterified fatty acids
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androgen-independent expression of enzyme in oral SSC cells, enzyme activity is necessary for their proliferation
medicine
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anorectic effect of C75 is independent of its inhibition of enzyme in the hypothalamus
medicine
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in cancer cells, enzyme plays a major role in the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Link between enzyme overexpression and dysregulation of membrane composition and functioning in tumor cells
medicine
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TRAMP mouse prostate adenocarcinoma cells show high enzyme expression and activity compared to nontransgenic littermates. Inhibition of enzyme expression and activity results in dose-dependent reduction in cell survival
medicine
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triclosan suppresses mammary carcinogenesis by inhibiting enzyme
medicine
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FAS could be a useful signal for early detection of ulcerative coliti
medicine
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FAS is a target for drug development against obesity and related diseases, and FAS inhibitors have antitumor activity
medicine
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the enzyme is a potential therapeutic target to treat cancer and obesity. Acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors
medicine
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endogenously synthesized fatty acids do not fulfill a specific function in cancer cells. Cancer cells do not produce fatty acids that are different from those derived from exogenous palmitate, these fatty acids are esterified to the same lipid and phospholipid classes in the same proportions, and their distribution within neutral lipids is not different from untransformed cells. Anoxia increases glycolysis 2-3fold, with no concomitant increase in lipogenesis
medicine
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fatty acid synthase expression, which is upregulated in many human cancers, causes resistance to multiple anticancer drugs via inhibiting drug-induced ceramide production, caspase 8 activation, and apoptosis. Fatty acid synthase overexpression suppresses tumor necrosis factor-alpha production and nuclear factor-kappaB activation as well as drug-induced activation of neutral sphingomyelinase
medicine
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fatty acid synthase-dependent palmitoylation of epidermal growth factor receptor is required for epidermal growth factor receptor dimerization and kinase activation. Inhibition of fatty acid synthase or palmitoyl acyltransferases reduces the activity and down-regulated the levels of epidermal growth factor receptor, and sensitizes cancer cells to epidermal growth factor receptor tyrosine kinase inhibitors