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2.3.1.85: fatty-acid synthase system

This is an abbreviated version!
For detailed information about fatty-acid synthase system, go to the full flat file.

Word Map on EC 2.3.1.85

Reaction

acetyl-CoA
+ 7 malonyl-CoA + 14 NADPH + 14 H+ =
hexadecanoate
 + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O

Synonyms

F09E10.3 protein, FAS, FAS-II, FASI, FASII, FASN, fatty acid synthase, fatty acid synthase I, fatty acid synthase II, fatty acid synthase type 2, fatty-acid synthase, type 2 dissociative FAS, type 2 fatty acid synthase, type II fatty acid synthase, yeast fatty acid synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.85 fatty-acid synthase system

IC50 Value

IC50 Value on EC 2.3.1.85 - fatty-acid synthase system

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0254
1,1'-[methanediylbis(2,4,6-trihydroxy-5-methylbenzene-3,1-diyl)]dibutan-1-one
Gallus gallus
-
IC50: 0.0254 mM
0.0016
1,2,3,4,6-penta-O-galloyl-beta-D-glucose
Homo sapiens
-
37°C, pH not specified in the publication
0.0491
1-(2,6-dihydroxy-4-methoxy-3-methylphenyl)butan-1-one
Gallus gallus
-
IC50: 0.0491 mM
0.0602
2,2'-methanediylbis(3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one)
Gallus gallus
-
IC50: 0.0602 mM
0.0231
2-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one
Gallus gallus
-
IC50: 0.0231 mM
0.0287
2-acetyl-6-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
Gallus gallus
-
IC50: 0.0287 mM
0.0297
2-acetyl-6-(3-butanoyl-2,4,6-trihydroxybenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
Gallus gallus
-
IC50: 0.0297 mM
0.0717
2-acetyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
Gallus gallus
-
IC50: 0.0717 mM
0.031
2-acetyl-6-{3-butanoyl-5-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-2,4,6-trihydroxybenzyl}-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
Gallus gallus
-
IC50: 0.031 mM
0.0326
2-butanoyl-6-(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
Gallus gallus
-
IC50: 0.0326 mM
0.0561
2-butanoyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
Gallus gallus
-
IC50: 0.0561 mM
0.0127
2-[(Z)-[2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]pyridine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0625
3-((1H-imidazo)-4-yl)-2-oxopropanoate
Gallus gallus
-
IC50: 0.0625 mM
0.013
3-chloro-4-hydroxybenzoyl-[aryl-carrier protein]
Gallus gallus
-
IC50: 0.013 mM
-
0.0295
4',6,7-trihydroxylisoflavone
Anas platyrhynchos
-
IC50: 0.0295 mM
0.151
5-chloropyrazinamide
Mycobacterium tuberculosis
-
IC50: 0.151 mM
0.0176
apigenin
Anas platyrhynchos
-
IC50: 0.0176 mM
0.00615
avicularin
Anas platyrhynchos
-
IC50: 0.00615 mM
0.013
cerulenin
Gallus gallus
-
pH 7.0, 37°C
0.0732
daidzein
Anas platyrhynchos
-
IC50: 0.0732 mM
0.017
ginkgolic acid C15:1
Gallus gallus
-
pH 7.0, 37°C
0.01
ginkgolic acid C17:1
Gallus gallus
-
pH 7.0, 37°C
0.009
ginkgolic acid C17:2
Gallus gallus
-
pH 7.0, 37°C
0.0746
hyperoside
Anas platyrhynchos
-
IC50: 0.0746 mM
0.0088
iso-liquiritigenin
Anas platyrhynchos
-
IC50: 0.0088 mM
0.108
isoquercitrin
Anas platyrhynchos
-
IC50: 0.108 mM
0.062
luteolin
Gallus gallus
-
pH 7.0, 37°C
0.093
nordihydroguaiaretic acid
Anas platyrhynchos
-
inhibits competitively with respect to acetyl-CoA, noncompetitively with respect to malonyl-CoA, and in a mixed manner with respect toNADPH.IC50 = 0.093 mM
8.9
Pyrazinamide
Mycobacterium tuberculosis
-
IC50: 8.9 mM
0.0456
quercitrin
Anas platyrhynchos
-
IC50: 0.0456 mM
0.0085
resveratrol
Anas platyrhynchos
-
IC50: 0.0085 mM
additional information
grape skin extract
-