2.3.1.85: fatty-acid synthase system
This is an abbreviated version!
For detailed information about fatty-acid synthase system, go to the full flat file.
Word Map on EC 2.3.1.85
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2.3.1.85
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mycobacterium
-
tuberculosis
-
mycolic
-
lipogenic
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enoyl
-
fasciclin
-
cerulenin
-
beta-ketoacyl-acyl
-
malonyl-coa
-
triclosan
-
isoniazid
-
transacylase
-
enoyl-acyl
-
beta-ketoacyl
-
thiolactomycin
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malonyl-acp
-
condensing
-
acyl-acps
-
malonyl
-
srebp-1c
-
fabgs
-
medicine
-
apicoplast
-
boutons
-
phosphopantetheinylation
-
4'-phosphopantetheine
-
ketoacyl
-
antituberculous
-
thiacetazone
-
nutrition
-
analysis
- 2.3.1.85
- mycobacterium
- tuberculosis
-
mycolic
-
lipogenic
-
enoyl
-
fasciclin
- cerulenin
-
beta-ketoacyl-acyl
- malonyl-coa
- triclosan
- isoniazid
-
transacylase
-
enoyl-acyl
-
beta-ketoacyl
- thiolactomycin
- malonyl-acp
-
condensing
- acyl-acps
-
malonyl
- srebp-1c
-
fabgs
- medicine
- apicoplast
-
boutons
-
phosphopantetheinylation
- 4'-phosphopantetheine
-
ketoacyl
-
antituberculous
- thiacetazone
- nutrition
- analysis
Reaction
Synonyms
F09E10.3 protein, FAS, FAS-II, FASI, FASII, FASN, fatty acid synthase, fatty acid synthase I, fatty acid synthase II, fatty acid synthase type 2, fatty-acid synthase, type 2 dissociative FAS, type 2 fatty acid synthase, type II fatty acid synthase, yeast fatty acid synthase
ECTree
2.3.1.85 fatty-acid synthase systemAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.85 - fatty-acid synthase system
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-hydroxybutanoyl-CoA + an [acyl-carrier protein]
CoA + 3-hydroxybutanoyl-[acyl-carrier protein]
-
-
-
?
3-methylbutanoyl-CoA + an [acyl-carrier protein]
CoA + 3-methylbutanoyl-[acyl-carrier protein]
-
-
-
?
acetoacetyl-CoA + an [acyl-carrier protein]
CoA + acetoacetyl-[acyl-carrier protein]
-
-
-
?
acetoacetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+
a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
acetyl-CoA + an [acyl-carrier protein]
CoA + acetyl-[acyl-carrier protein]
-
-
-
?
acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+
a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+
-
-
-
?
butanoyl-CoA + an [acyl-carrier protein]
CoA + butanoyl-[acyl-carrier protein]
-
-
-
?
butanoyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+
a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+
-
-
-
?
crotonyl-CoA + an [acyl-carrier protein]
CoA + crotonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
methylmalonyl-CoA + an [acyl-carrier protein]
CoA + a methylmalonyl-[acyl-carrier protein]
-
-
-
?
octanoyl-CoA + an [acyl-carrier protein]
CoA + octanoyl-[acyl-carrier protein]
-
-
-
?
octanoyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+
a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+
-
-
-
?
palmitoyl-CoA + an [acyl-carrier protein]
CoA + palmitoyl-[acyl-carrier protein]
-
-
-
?
phenylacetyl-CoA + an [acyl-carrier protein]
CoA + phenylacetyl-[acyl-carrier protein]
-
-
-
?
succinyl-CoA + an [acyl-carrier protein]
CoA + succinyl-[acyl-carrier protein]
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
C20 and C22 fatty acids in the absence of thioesterase activity, methylmalonyl-CoA instead of malonyl-CoA yields branched fatty acid, e.g. 2,4,6,8-tetramethyldecanoic acid
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
C20 and C22 fatty acids in the absence of thioesterase activity
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
C20 and C22 fatty acids in the absence of thioesterase activity
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
decanoyl-CoA, acetyl-CoA, butyryl-CoA and malonyl-CoA are bound to the same active site
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
C20 and C22 fatty acids in the absence of thioesterase activity
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
specific for malonyl-CoA, acetyl-CoA can be replaced by propionyl-CoA or butyryl-CoA
in the absence of NADPH the product is triacetic acid lactone
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
FAS-A mainly synthesizes the C18 fatty acids oleate and stearate with only traces of palmitate, the major product of FAS-B is pamitate
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
C20 and C22 fatty acids in the absence of thioesterase activity
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
in the absence of NADPH the product is triacetic acid lactone
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
participates in energy metabolism in vivo which is related to adiposis and cancer
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
C20 and C22 fatty acids in the absence of thioesterase activity
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
acetoacetyl-CoA can substitute for acetyl-CoA
small amounts of stearate and myristate are also produced
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
C20 and C22 fatty acids in the absence of thioesterase activity
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
lactating mammary gland thioesterase II of fatty acid synthetase: products are medium chain fatty acids from C8 to C12, C20 and C22 fatty acids in the absence of thioesterase activity
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
lactating mammary gland thioesterase II of fatty acid synthetase: products are medium chain fatty acids from C8 to C12, C20 and C22 fatty acids in the absence of thioesterase activity
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
products are fatty acid chains from C14 to C20
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
-
in the absence of NADPH the product is triacetic acid lactone
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
additional information
?
-
-
carries acetyl- and malonyl-CoA transacylase, condensing enzyme, beta-ketoacyl reductase, beta-hydroxyacyl dehydrase, enoylacyl reductase, palmitoyl-CoA thioesterase activities on each multifunctional subunit
-
-
?
additional information
?
-
-
fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes
-
-
?
additional information
?
-
-
fatty acid synthase-dependent palmitoylation of epidermal growth factor receptor is required for epidermal growth factor receptor dimerization and kinase activation. Inhibition of fatty acid synthase or palmitoyl acyltransferases reduces the activity and down-regulated the levels of epidermal growth factor receptor, and sensitizes cancer cells to epidermal growth factor receptor tyrosine kinase inhibitors
-
-
?
additional information
?
-
-
enzyme generated signals are needed to support preadipocyte differentiation
-
-
?
additional information
?
-
under non-reducing conditions in the absence of NADPH, FASN produces triacetic acid lactone with an averaged malonyl consumption rate of 46 nmol per min per mg protein
-
-
-
additional information
?
-
-
fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes
-
-
?
additional information
?
-
-
synthesizes equal amounts of C14 and C16 fatty acids
-
-
?
