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2.3.1.86: fatty-acyl-CoA synthase system

This is an abbreviated version!
For detailed information about fatty-acyl-CoA synthase system, go to the full flat file.

Word Map on EC 2.3.1.86

Reaction

acetyl-CoA
+ 7 malonyl-CoA + 14 NADPH + 14 H+ =
hexadecanoyl-CoA
+ 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O

Synonyms

CpFas2, FAS, FAS1, fas2, fatty acid synthase, fatty-acyl-CoA synthase, yeast fatty acid synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.86 fatty-acyl-CoA synthase system

Activating Compound

Activating Compound on EC 2.3.1.86 - fatty-acyl-CoA synthase system

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-O-methylmannose
-
0.1 mM, lowers Km 4fold, activation by relieving product inhibition by binding long-chain acyl-CoA
6-O-methylglucose
-
0.1 mM, lowers Km 4fold, activation by relieving product inhibition by binding long-chain acyl-CoA
ATP
-
stimulatory at suboptimal but not at saturating substrate concentrations
cysteine
glutathione
-
activation
Triton X-100
additional information
-
no activation by DTT
-