2.3.1.86: fatty-acyl-CoA synthase system

This is an abbreviated version!
For detailed information about fatty-acyl-CoA synthase system, go to the full flat file.

+ 7 malonyl-CoA + 14 NADPH + 14 H+ =

+ 7 CoA + 7 CO2 + 14 NADP⁺ + 7 H2O

CpFas2, FAS, FAS1, fas2, fatty acid synthase, fatty-acyl-CoA synthase, yeast fatty acid synthase

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Results	in table
9	Activating Compound
1828	AA Sequence
7	Application
1	CAS Registry Number
9	Cloned(Commentary)
22	Cofactor
6	Crystallization (Commentary)
2	Expression
6	General Information
5	General Stability
16	Inhibitors
12	KM Value [mM]
7	Localization
29	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
78	Organism
2	Oxidation Stability
7	Pathway
98	PDB ID
1	pH Optimum
18	Protein Variants
19	Purification (Commentary)
11	Reaction
3	Reaction Type
50	Reference
2	Renatured (Commentary)
1	Source Tissue
16	Specific Activity [micromol/min/mg]
4	Storage Stability
39	Substrates and Products (Substrate)
20	Subunits
13	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

General Stability on EC 2.3.1.86 - fatty-acyl-CoA synthase system

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2-mercaptoethanol, inactivation during storage

acylation of free protein amino groups leads to reversible dissociation into subunits

low ionic strength leads to inactivation

low ionic strength, 0.005 M, leads to dissociation into subunits, partially reactivated by increasing the ionic strength to 0.5 M

PMSF ensures isolation of native enzyme