2.3.1.86: fatty-acyl-CoA synthase system

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For detailed information about fatty-acyl-CoA synthase system, go to the full flat file.

Word Map on EC 2.3.1.86

2.3.1.86

udp-glucuronosyltransferase

glucuronidation

farnesoid

carvedilol

extrahepatic

acid-conjugating

parapsilosis

hyodeoxycholic

4-hydroxyestrone

analysis

medicine

biofuel production

Reaction

+ 7 malonyl-CoA + 14 NADPH + 14 H+ =

+ 7 CoA + 7 CO2 + 14 NADP⁺ + 7 H2O

Synonyms

CpFas2, FAS, FAS1, fas2, fatty acid synthase, fatty-acyl-CoA synthase, yeast fatty acid synthase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.86 fatty-acyl-CoA synthase system

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Results	in table
9	Activating Compound
1828	AA Sequence
7	Application
1	CAS Registry Number
9	Cloned(Commentary)
22	Cofactor
6	Crystallization (Commentary)
2	Expression
6	General Information
5	General Stability
16	Inhibitors
12	KM Value [mM]
7	Localization
29	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
78	Organism
2	Oxidation Stability
7	Pathway
98	PDB ID
1	pH Optimum
18	Protein Variants
19	Purification (Commentary)
11	Reaction
3	Reaction Type
50	Reference
2	Renatured (Commentary)
1	Source Tissue
16	Specific Activity [micromol/min/mg]
4	Storage Stability
39	Substrates and Products (Substrate)
20	Subunits
13	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.3.1.86 - fatty-acyl-CoA synthase system

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acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)

The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, while the other subunit catalyses the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 4.2.1.59, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.1.1.279, (R)-3-hydroxyacid-ester dehydrogenase. The enzyme system differs from the animal system (EC 2.3.1.85, fatty-acid synthase system) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.