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2.3.1.94: 6-deoxyerythronolide-B synthase

This is an abbreviated version!
For detailed information about 6-deoxyerythronolide-B synthase, go to the full flat file.

Word Map on EC 2.3.1.94

Reaction

propanoyl-CoA
+ 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ =
6-Deoxyerythronolide b
 + 7 CoA + 6 CO2 +
H2O
 + 6 NADP+

Synonyms

6-deoxyerythronolide B, 6-deoxyerythronolide B synthase, DEBS, DEBS1, DEBS2, DEBS3, deoxyerythronolide B synthase, deoxyerythronolide B synthase 1, deoxyerythronolide B synthase 2, deoxyerythronolide B synthase 3, eryA, erythromycin polyketide synthase, erythronolide condensing enzyme, erythronolide synthase, PKS, polyketide synthase, synthase, erythronolide

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.94 6-deoxyerythronolide-B synthase

Application

Application on EC 2.3.1.94 - 6-deoxyerythronolide-B synthase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
kinetic assay for the megasynthase that stoichiometrically relates NADPH consumption to polyketide production
biotechnology
synthesis
the deoxyerythronolide B synthase genes are functionally expressed in Bacillus subtilis when the native eryAI–III operon is separated into three individual expression cassettes with optimized ribosomal binding sites. A synthesis of 6-deoxyerythronolide B can be detected by using the acetoininducible acoA promoter and a fed-batch simulating EnBase-cultivation strategy. Bacillus subtilis is capable of the secretion of 6-deoxyerythronolide B into the medium. The deletion of the prpBD operon of Bacillus subtilis, responsible for propionyl-CoA utilization, results in a significant increase of the 6-deoxyerythronolide B product yield when exogenous propionate is provided