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2.3.1.94: 6-deoxyerythronolide-B synthase

This is an abbreviated version!
For detailed information about 6-deoxyerythronolide-B synthase, go to the full flat file.

Word Map on EC 2.3.1.94

Reaction

propanoyl-CoA
+ 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ =
6-Deoxyerythronolide b
+ 7 CoA + 6 CO2 +
H2O
+ 6 NADP+

Synonyms

6-deoxyerythronolide B, 6-deoxyerythronolide B synthase, DEBS, DEBS1, DEBS2, DEBS3, deoxyerythronolide B synthase, deoxyerythronolide B synthase 1, deoxyerythronolide B synthase 2, deoxyerythronolide B synthase 3, eryA, erythromycin polyketide synthase, erythronolide condensing enzyme, erythronolide synthase, PKS, polyketide synthase, synthase, erythronolide

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.94 6-deoxyerythronolide-B synthase

Crystallization

Crystallization on EC 2.3.1.94 - 6-deoxyerythronolide-B synthase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
small-angle X-ray scattering analyses of a whole module and a bimodule from 6-deoxyerythronolide B synthase DEBS, as well as a set of domains. Data support a model in which the third module of DEBS forms a disc-shaped structure capable of caging the acyl carrier protein domain proximal to each active site. The molecular envelope of DEBS3 is a thin elongated ellipsoid, and the modules 5 and 6 stack collinearly along the 2fold axis of symmetry
structures of a construct of DEBS thioesterase domain alone at 1.7 A, and DEBS thioesterase domain bound with a simple allylphosphonate, prop-2-en-1-ylphosphonic acid, at 2.1 A resolution
the crystal structure of the thioesterase domain from deoxyerythronolide B synthase is solved to 2.8 A resolution