2.3.1.94: 6-deoxyerythronolide-B synthase
This is an abbreviated version!
For detailed information about 6-deoxyerythronolide-B synthase, go to the full flat file.
Word Map on EC 2.3.1.94
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2.3.1.94
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synthases
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aspergillus
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nonribosomal
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ketosynthase
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macrolide
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acyltransferase
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starter
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iterative
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thioesterase
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ketoreductase
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actinomycete
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melanin
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coelicolor
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erythraea
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mycotoxin
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saccharopolyspora
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macrolactone
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macrocyclic
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polyene
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actinorhodin
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beta-ketoacyl
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ochratoxin
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citrinin
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monascus
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enoyl
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deoxysugars
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multimodular
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fujikuroi
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hygroscopicus
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myxobacterium
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verticillioides
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avermitilis
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avermectins
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phosphopantetheinylated
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macrolactams
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pyrone
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16-membered
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phosphopantetheine
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rifamycins
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bimodular
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epothilone
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nrpss
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halogenase
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ansamycins
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synthesis
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ochraceus
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pptases
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antibioticus
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biotechnology
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enediyne
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meroterpenoids
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analysis
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4'-phosphopantetheine
- 2.3.1.94
- synthases
- aspergillus
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nonribosomal
-
ketosynthase
-
macrolide
- acyltransferase
-
starter
-
iterative
-
thioesterase
- ketoreductase
-
actinomycete
- melanin
- coelicolor
- erythraea
-
mycotoxin
- saccharopolyspora
-
macrolactone
-
macrocyclic
-
polyene
-
actinorhodin
-
beta-ketoacyl
-
ochratoxin
- citrinin
- monascus
-
enoyl
-
deoxysugars
-
multimodular
- fujikuroi
- hygroscopicus
-
myxobacterium
- verticillioides
- avermitilis
- avermectins
-
phosphopantetheinylated
-
macrolactams
-
pyrone
-
16-membered
- phosphopantetheine
- rifamycins
-
bimodular
-
epothilone
-
nrpss
- halogenase
-
ansamycins
- synthesis
- ochraceus
- pptases
- antibioticus
- biotechnology
-
enediyne
-
meroterpenoids
- analysis
- 4'-phosphopantetheine
Reaction
Synonyms
6-deoxyerythronolide B, 6-deoxyerythronolide B synthase, DEBS, DEBS1, DEBS2, DEBS3, deoxyerythronolide B synthase, deoxyerythronolide B synthase 1, deoxyerythronolide B synthase 2, deoxyerythronolide B synthase 3, eryA, erythromycin polyketide synthase, erythronolide condensing enzyme, erythronolide synthase, PKS, polyketide synthase, synthase, erythronolide
ECTree
2.3.1.94 6-deoxyerythronolide-B synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.94 - 6-deoxyerythronolide-B synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+
propanoyl-CoA + (2S)-methylmalonyl-CoA + NADPH
(3R,4S,5R,6R)-6-ethyl-4-hydroxy-3,5-dimethyloxan-2-one + ?
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-
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?
propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+
(3R,4S,5R,6R)-6-ethyl-4-hydroxy-3,5-dimethyltetrahydro-2H-pyran-2-one + ?
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product of truncated enzyme consisting of loading didomain-module1-module2+thioesterase
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?
propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+
(3R,5R,6S)-6-[(2S,3R)-3-hydroxypentan-2-yl]-3,5-dimethyldihydro-2H-pyran-2,4(3H)-dione + ?
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product of truncated enzyme consisting of loading didomain-module1-module2-module3+thioesterase
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?
propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+
8-ethyl-8-desmethyl-6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
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putative analog, 8-ethyl-8-desmethyl-6-deoxyerythronolide B, is generated by the assembly line in the presence of non-limiting concentrations of ethylmalonyl-CoA and is produced in comparable amounts to the natural 6-dEB product
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?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
6 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+
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-
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?
6 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+
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formation of a key intermediate in the biosynthesis of erythromycin
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?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
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-
-
-
?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
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-
-
?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
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-
-
?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
-
-
?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
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-
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?
additional information
?
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unidirectional translocation of the growing polyketide chain along the 6-deoxyerythronolide B synthase, ratchet mechanism, overview
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?
additional information
?
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the cis-acyltransferase domain from DEBS module 3 transfers a methylmalonyl extender unit from the corresponding carboxyacyl-CoA precursor onto the phosphopantetheine arm of the acyl carrier protein within the same module. The presence of the acyl carrier protein has little effect on the specificity of the cis-acyltransferase domain for carboxyacyl-CoA substrates, but has a marked influence on the corresponding specificity parameters for the trans-acyltransferases from the disorazole and kirromycin synthases. Comparative analysis of the substrate specificity
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?
