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2.3.1.94: 6-deoxyerythronolide-B synthase

This is an abbreviated version!
For detailed information about 6-deoxyerythronolide-B synthase, go to the full flat file.

Word Map on EC 2.3.1.94

Reaction

propanoyl-CoA
+ 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ =
6-Deoxyerythronolide b
 + 7 CoA + 6 CO2 +
H2O
 + 6 NADP+

Synonyms

6-deoxyerythronolide B, 6-deoxyerythronolide B synthase, DEBS, DEBS1, DEBS2, DEBS3, deoxyerythronolide B synthase, deoxyerythronolide B synthase 1, deoxyerythronolide B synthase 2, deoxyerythronolide B synthase 3, eryA, erythromycin polyketide synthase, erythronolide condensing enzyme, erythronolide synthase, PKS, polyketide synthase, synthase, erythronolide

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.94 6-deoxyerythronolide-B synthase

Systematic Name

Systematic Name on EC 2.3.1.94 - 6-deoxyerythronolide-B synthase

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SYSTEMATIC NAME
IUBMB Comments
propanoyl-CoA:(2S)-methylmalonyl-CoA malonyltransferase (cyclizing)
The product, 6-deoxyerythronolide B, contains a 14-membered lactone ring and is an intermediate in the biosynthesis of erythromycin antibiotics. Biosynthesis of 6-deoxyerythronolide B requires 28 active sites that are precisely arranged along three large polypeptides, denoted DEBS1, -2 and -3 [6]. The polyketide product is synthesized by the processive action of a loading didomain, six extension modules and a terminal thioesterase domain [5]. Each extension module contains a minimum of a ketosynthase (KS), an acyltransferase (AT) and an acyl-carrier protein (ACP). The KS domain both accepts the growing polyketide chain from the previous module and catalyses the subsequent decarboxylative condensation between this substrate and an ACP-bound methylmalonyl extender unit, introduce by the AT domain. This combined effort gives rise to a new polyketide intermediate that has been extended by two carbon atoms [5].