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2.3.1.97: glycylpeptide N-tetradecanoyltransferase

This is an abbreviated version!
For detailed information about glycylpeptide N-tetradecanoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.97

Reaction

tetradecanoyl-CoA
+
an N-terminal-glycyl-[protein]
=
CoA
 +
an N-terminal-N-tetradecanoylglycyl-[protein]

Synonyms

CaNMT, cell division control protein 72, dipeptide N-myristoyltransferase 2, glycylpeptide N-tetradecanoyltransferase, glycylpeptide N-tetradecanoyltransferase 1, glycylpeptide N-tetradecanoyltransferase 2, HsNMT1, HsNMT2, LmNMT, More, myristoyl-CoA-protein N-myristoyltransferase, myristoyl-CoA: protein N-myristoyltransferase, myristoyl-CoA:protein N-myristoyltransferase, myristoyl-CoA:protein N-myristoyltransferase 1, myristoyl-CoA:protein N-myristoyltransferase 2, myristoyl-CoA:protein N-myristoyltransferase type 2, myristoyl-coenzyme A:protein N-myristoyl transferase, myristoyl-coenzyme A:protein N-myristoyltransferase, myristoylating enzymes, myristoyltransferase, myristoyltransferase type 1, myristoyltransferase, protein N-, N-myristoyl transferase, N-myristoyltransferase, N-myristoyltransferase 1, N-myristoyltransferase 2, NMT, NMT 1, NMT 2, NMT-1, NMT-2, NMT1, Nmt1p, NMT2, peptide N-myristoyltransferase, peptide N-myristoyltransferase 1, peptide N-myristoyltransferase 2, protein N-myristoyltransferase, PVX_085815, TbNMT, type I N-myristoyltransferase, type II N-myristoyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.97 glycylpeptide N-tetradecanoyltransferase

Source Tissue

Source Tissue on EC 2.3.1.97 - glycylpeptide N-tetradecanoyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
elevated NMT activity and higher protein expressions. Higher NMT activity in WHO grade I malignancy, compared with others of higher WHO grades
Manually annotated by BRENDA team
-
cardiac, low activity
Manually annotated by BRENDA team
-
the myristoylated tyrosine kinases, pp60c-src and pp60c-yes, are observed to be several fold higher in colonic preneoplastic lesions and neoplasms compared with normal colon cells
Manually annotated by BRENDA team
-
the myristoylated tyrosine kinases, pp60c-src and pp60c-yes, are observed to be several fold higher in colonic preneoplastic lesions and neoplasms compared with normal colon cells
Manually annotated by BRENDA team
-
overexpression of NMT2. Caspase-3 interacts with NMT2
Manually annotated by BRENDA team
overexpression of NMT2 in colorectal cancer tissues
Manually annotated by BRENDA team
-
elevated NMT1 expression
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
N-myristoyltransferase 1 is not essential for the viability of mammalian cells but is required for development, likely because it is the principal N-myristoyltransferase in early embryogenesis
Manually annotated by BRENDA team
-
lung, NMT1
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
erythroleukemia cell line
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
leukemic cell line
Manually annotated by BRENDA team
-
increased in the myocardium of ischemia-reperfusion rat model myocardium. Rats with mild or no detectable Parkinson syndrome features on rotenone show slight but insignificantly increased activity. Rats with moderately severe Parkinson syndrome features have higher level of NMT activity, which is borderline significant compared to controls. Rats with severe PS features had the highest NMT activity which is significantly greater compared to controls and to the rats with equivocal or no motor slowing
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
additional information