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2.3.1.B25: octaketide synthase

This is an abbreviated version!
For detailed information about octaketide synthase, go to the full flat file.

Word Map on EC 2.3.1.B25

Reaction

16 malonyl-CoA + 28 H+ = 16 CoA +

2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one
+
2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one
+ 16 CO2 + 16 H2O

Synonyms

AaOKS, DynE8, enediyne PKS, enediyne polyketide synthase, OKS, oktaketide synthase, PksE, plant type III OKS, plant type III polyketide synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.B25 octaketide synthase

Reference

Reference on EC 2.3.1.B25 - octaketide synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Abe, I.
Engineering of plant polyketide biosynthesis
Chem. Pharm. Bull.
56
1505-1514
2008
Aloe arborescens (Q3L7F5)
Manually annotated by BRENDA team
Watanabe, K.; Praseuth, A.P.; Wang, C.C.
A comprehensive and engaging overview of the type III family of polyketide synthases
Curr. Opin. Chem. Biol.
11
279-286
2007
Aloe arborescens (Q3L7F5)
Manually annotated by BRENDA team
Lee, Y.S.; Ju, H.K.; Kim, Y.J.; Lim, T.G.; Uddin, M.R.; Kim, Y.B.; Baek, J.H.; Kwon, S.W.; Lee, K.W.; Seo, H.S.; Park, S.U.; Yang, T.J.
Enhancement of anti-inflammatory activity of Aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation
PLoS ONE
8
e82479
2013
Aloe vera
Manually annotated by BRENDA team
Andersen-Ranberg, J.; Kongstad, K.T.; Nafisi, M.; Staerk, D.; Okkels, F.T.; Mortensen, U.H.; Lindberg Moeller, B.; Frandsen, R.J.N.; Kannangara, R.
Synthesis of C-glucosylated octaketide anthraquinones in Nicotiana benthamiana by using a multispecies-based biosynthetic pathway
ChemBioChem
18
1893-1897
2017
Aloe arborescens (Q3L7F5)
Manually annotated by BRENDA team
Cohen, D.; Townsend, C.
A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
Nat. Chem.
10
231-236
2018
Micromonospora chersina (Q84HI8), Micromonospora chersina, Micromonospora chersina NRRL B-24756 (Q84HI8)
Manually annotated by BRENDA team
Frandsen, R.J.N.; Khorsand-Jamal, P.; Kongstad, K.T.; Nafisi, M.; Kannangara, R.M.; Staerk, D.; Okkels, F.T.; Binderup, K.; Madsen, B.; Moller, B.L.; Thrane, U.; Mortensen, U.H.
Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans
Sci. Rep.
8
12853
2018
Aloe arborescens (Q3L7F5)
Manually annotated by BRENDA team