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2.3.1.B38: heptylquinolone synthase

This is an abbreviated version!
For detailed information about heptylquinolone synthase, go to the full flat file.

Word Map on EC 2.3.1.B38

Reaction

octanoyl-CoA
+
2-aminobenzoylacetate
=
2-heptylquinolin-4(1H)-one
+
CO2
+
H2O

Synonyms

2-heptyl-4(1H)-quinolone synthase, PqsB, PqsBC, PqsC

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.B38 heptylquinolone synthase

Engineering

Engineering on EC 2.3.1.B38 - heptylquinolone synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C129A
mutation in catalytic dyad, crystallization data
V299N
substitution leads to significant activity toward the deamino substrate analog benzoylacetate, suggesting that the substrate 2-aminobenzoylacetate itself supplies the asparagine-equivalent amino function that assists in catalysis
additional information