2.3.2.13: protein-glutamine gamma-glutamyltransferase
This is an abbreviated version!
For detailed information about protein-glutamine gamma-glutamyltransferase, go to the full flat file.
Word Map on EC 2.3.2.13
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2.3.2.13
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celiac
-
coagulation
-
clot
-
fibrinogen
-
crosslinking
-
gluten
-
serological
-
bleeding
-
thrombin
-
autoimmune
-
children
-
autoantibody
-
platelet
-
gluten-free
-
keratinocytes
-
anti-tissue
-
gliadin
-
collagen
-
duodenal
-
igg
-
bowel
-
deamidated
-
fibronectin
-
villous
-
keratin
-
fibrinolysis
-
plasminogen
-
isopeptide
-
involucrin
-
enteropathy
-
prothrombin
-
cornified
-
plasmin
-
hemostatic
-
endoscopy
-
marsh
-
gelation
-
texture
-
ichthyosis
-
fibrinopeptide
-
cryoprecipitate
-
gastroenterology
-
rheological
-
leiden
-
malabsorption
-
filaggrin
-
nutrition
-
analysis
-
agriculture
-
diagnostics
-
antifibrinolytic
-
medicine
-
synthesis
-
food industry
-
biotechnology
-
histiocytomas
-
sealant
-
2-antiplasmin
- 2.3.2.13
- celiac
- coagulation
- clot
- fibrinogen
-
crosslinking
- gluten
-
serological
- bleeding
- thrombin
- autoimmune
- children
- autoantibody
- platelet
-
gluten-free
- keratinocytes
-
anti-tissue
- gliadin
- collagen
- duodenal
- igg
- bowel
-
deamidated
- fibronectin
-
villous
- keratin
-
fibrinolysis
- plasminogen
-
isopeptide
- involucrin
- enteropathy
- prothrombin
-
cornified
- plasmin
-
hemostatic
-
endoscopy
-
marsh
-
gelation
-
texture
- ichthyosis
-
fibrinopeptide
-
cryoprecipitate
-
gastroenterology
-
rheological
- leiden
-
malabsorption
- filaggrin
- nutrition
- analysis
- agriculture
- diagnostics
-
antifibrinolytic
- medicine
- synthesis
- food industry
- biotechnology
- histiocytomas
-
sealant
-
2-antiplasmin
Reaction
Synonyms
AcTG-1, BmTGA, chloroplast transglutaminase, chlTGase, cold active transglutaminase, cold-active transglutaminase, EPB42, factor XIII, factor XIIIa, fibrin stabilizing factor, fibrinoligase, Galphah, glutamine:amine gamma-glutamyl-transferase, glutaminylpeptide gamma-glutamyltransferase, glutamyltransferase, glutaminylpeptide gamma-, gpTGase 2, gTG2, hfXIIIa, hTG2, hTGase 1, hTGase 2, hTGase 3, hTGase 6, KALB, KalbTG, KALB_7456, Laki-Lorand factor, mammalian transglutaminase, microbial transglutaminase, microbial transglutaminases, MsTGase, MTG, MTG-TX, MTGase, mTGase 2, OlTGT, plastidial transglutaminase, polyamine transglutaminase, protein 4.2, protein-glutamine gamma-glutamyltransferase, R-glutaminyl-peptide:amine gamma-glutamyl transferase, R-glutaminylpeptide-amine gamma-glutamyltransferase, SCTG, SMTG, STG I, t-TG, TG-2, TG1, TG2, TG3, TG4, TG5, TG6, TG7, tGA, TGase, TGase 1, TGase 2, Tgase 3, TGase 6, Tgase II, TGase-2, TGase2, TGB, TGK1, TGK2, TGL, TGM1, TGM2, TGM3, TGM4, TGM5, TGM6, TGM7, TGZ, tgz15, TGZo, tissue transglutaminase, tissue transglutaminase 2, tissue-TG, transglutaminase, transglutaminase 1, transglutaminase 2, transglutaminase 3, transglutaminase 6, transglutaminase C, transglutaminase factor XIII, transglutaminase type II, transglutaminase-2, transglutaminase-like protein, transglutaminase2, tTG, tTG-2, type 2 transglutaminase, type I transglutaminase, type-2 transglutaminase
ECTree
2.3.2.13 protein-glutamine gamma-glutamyltransferaseAdvanced search results
results (
results (IC50 Value
IC50 Value on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase
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IC50 VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.000273
(2-tert-butoxy-2-oxoethyl)(dimethyl)sulfonium
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0007
(2-[[(1R)-3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-1-carboxy-3-oxopropyl]amino]-2-oxoethyl)(dimethyl)sulfanium bromide
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0033
(2-[[4-(methoxycarbonyl)benzyl]oxy]-2-oxoethyl)(dimethyl)sulfonium
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0015
(2-[[6-(methoxycarbonyl)naphthalen-2-yl]methoxy]-2-oxoethyl)(dimethyl)sulfonium
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0015
(3E)-1-benzyl-4-chloro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0036
(3E)-3-(2-oxopropylidene)-6-(trifluoromethoxy)-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0014
(3E)-3-[2-(3-aminophenyl)-2-oxoethylidene]-4-chloro-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0011
(3E)-3-[2-(4-aminophenyl)-2-oxoethylidene]-4-chloro-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0014
(3E)-3-[2-(5-bromopyridin-3-yl)-2-oxoethylidene]-4-chloro-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.022
(3E)-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0009
(3E)-4-bromo-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.001
(3E)-4-chloro-1-(2-methylpropyl)-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0021
(3E)-4-chloro-1-(cyclohexylmethyl)-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.004
(3E)-4-chloro-1-methyl-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0028
(3E)-4-chloro-3-(2-oxo-2-phenylethylidene)-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0015
(3E)-4-chloro-3-(2-oxopropylidene)-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0009
(3E)-4-chloro-3-[2-(2-methoxyphenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0007
(3E)-4-chloro-3-[2-(3-chlorophenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.001
(3E)-4-chloro-3-[2-(3-methoxyphenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0008
(3E)-4-chloro-3-[2-(4-chlorophenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0011
(3E)-4-chloro-3-[2-(4-methoxyphenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0014
(3E)-4-chloro-3-[2-(6-methoxypyridin-3-yl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0011
(3E)-4-chloro-3-[2-oxo-2-(pyridin-2-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0009
(3E)-4-chloro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0015
(3E)-4-chloro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0013
(3E)-4-chloro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1-(3-phenylpropyl)-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0014
(3E)-4-chloro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1-(propan-2-yl)-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0008
(3E)-4-chloro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1-phenyl-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0012
(3E)-4-chloro-3-[2-oxo-2-(pyridin-4-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0048
(3E)-5-bromo-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0043
(3E)-5-chloro-3-(2-oxopropylidene)-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.006
(3E)-5-chloro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0063
(3E)-5-methyl-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0079
(3E)-5-nitro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0015
(3E)-6-bromo-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0021
(3E)-6-chloro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.011
(3E)-6-fluoro-3-(2-oxopropylidene)-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0029
(3E)-7-bromo-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0047
(3E)-7-chloro-3-(2-oxopropylidene)-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0073
(3E)-7-chloro-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.018
(4R)-1-[(benzyloxy)carbonyl]-4-hydroxy-L-prolyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.0069
(5-bromothiophen-2-yl)(4-methyl-1H-pyrazol-1-yl)methanone
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0107
(E)-1-(1-(2-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-3-(4-nitrophenyl)prop-2-en-1-one
Cavia cutleri
25°C, pH 7.0
0.0094
(E)-1-(1-(3-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-3-(4-nitrophenyl)prop-2-en-1-one
Cavia cutleri
25°C, pH 7.0
0.0021
(E)-1-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)-3-(4-nitrophenyl)prop-2-en-1-one
Cavia cutleri
25°C, pH 7.0
0.011
(E)-1-(1-(cyclohexylmethyl)-1H-1,2,3-triazol-4-yl)-3-(4-nitrophenyl)prop-2-en-1-one
Cavia cutleri
25°C, pH 7.0
0.0043
(E)-1-(1-benzyl-1H-1,2,3-triazol-4-yl)-3-(4-nitrophenyl)prop-2-en-1-one
Cavia cutleri
25°C, pH 7.0
0.000029
(naphthalen-2-yl)methyl 4-[N-(bromoacetyl)glycyl]piperazine-1-carboxylate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.018
1,1'-methanediylbis(1H-indole-2,3-dione)
Homo sapiens
-
pH and temperature not specified in the publication
0.25
1,1'-[(2,5-dimethylbenzene-1,4-diyl)dimethanediyl]bis(1H-indole-2,3-dione)
Homo sapiens
-
IC50 above 0.25 mM, pH and temperature not specified in the publication
0.04
1,1'-[(4,6-dimethylbenzene-1,3-diyl)dimethanediyl]bis(1H-indole-2,3-dione)
Homo sapiens
-
pH and temperature not specified in the publication
0.00021
1-(1-benzothiophen-2-yl)-3-[benzyl(tert-butyl)amino]propan-1-one
Cavia porcellus
-
pH 7.5
0.000875
1-(ethenylsulfonyl)tricyclo[3.3.1.13,7]decane
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.00012
1-(furan-2-yl)-3-[(2-hydroxyethyl)(propan-2-yl)amino]propan-1-one
Cavia porcellus
-
pH 7.5
0.000125
1-(tricyclo[3.3.1.13,7]dec-1-yl)prop-2-en-1-one
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.000025
1-ethyl-3-(4-methoxyphenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.033
1-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-1-ium-3-olate
Cavia porcellus
-
pH 7.0, 25
0.005
1-[(benzyloxy)carbonyl]-L-prolyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.0009
2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl prop-2-enoate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.1
2-([2-[(3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-2,3-dioxopropyl)amino]-2-oxoethyl]sulfanyl)-1,3,4,5-tetramethyl-1H-imidazol-3-ium bromide
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0000039
2-bromo-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethanone
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.00000875
2-chloro-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethanone
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0055
2-[(3E)-4-chloro-2-oxo-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-2,3-dihydro-1H-indol-1-yl]-N,N-dimethylacetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.028
3-(3-methyl-3H-diaziren-3-yl)-N-[4-[(1E)-3-oxo-3-(pyridin-3-yl)prop-1-en-1-yl]phenyl]propanamide
Cavia porcellus
-
pH 7.0, 25°C
0.0005 - 0.00058
3-(4-acryloylaminobenzenesulfonylamino)-(R)-pyrrolidine-1-carboxylic acid benzyl ester
0.000096 - 0.00052
3-(4-acryloylaminobenzenesulfonylamino)-(S)-pyrrolidine-1-carboxylic acid benzyl ester
0.024
3-[(2E)-3-(3-nitrophenyl)prop-2-enoyl]-1H-benzotriazol-3-ium-1-olate
Cavia porcellus
-
pH 7.0, 25
0.00042
3-[benzyl(ethyl)amino]-1-(5-chlorothiophen-2-yl)propan-1-one
Cavia porcellus
-
pH 7.5
0.00019
3-[benzyl(propan-2-yl)amino]-1-(5-bromothiophen-2-yl)propan-1-one
Cavia porcellus
-
pH 7.5
0.00023
3-[benzyl(propan-2-yl)amino]-1-(5-chlorothiophen-2-yl)propan-1-one
Cavia porcellus
-
pH 7.5
0.000081
3-[benzyl(tert-butyl)amino]-1-(5-bromothiophen-2-yl)propan-1-one
Cavia porcellus
-
pH 7.5
0.0001
3-[benzyl(tert-butyl)amino]-1-(5-chlorothiophen-2-yl)propan-1-one
Cavia porcellus
-
pH 7.5
0.000069
4-(2-acryloylaminopyrimidine-5-sulfonyl)piperazine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000026
4-(2-acryloylaminopyrimidine-5-sulfonyl)piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00035
4-(3-acryloylaminobenzenesulfonyl)piperazine-1-carboxylicacid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00011
4-(4-acryloylamino-2-chlorobenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00019
4-(4-acryloylamino-2-fluorobenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0025
4-(4-acryloylamino-2-methoxybenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00091
4-(4-acryloylamino-2-methylbenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00018
4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)-piperazine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.013
4-(4-acryloylamino-3-fluorobenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000094
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00007
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-methylbenzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00011
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-trifluoromethylbenzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00007
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 3,5-difluorobenzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00012
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000044
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid cyclopentyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00011
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid methyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0000821
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid naphthalen-1-ylmethyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00022
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid naphthalen-2-ylmethyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0012
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000046
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylicacid 2,3-difluorobenzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000054
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylicacid 4-fluorobenzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000072
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylicacid ethyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00046
4-(4-acryloylaminobenzenesulfonyl)[1,4]diazepane-1-carboxylicacid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00045
4-(4-acryloylaminobenzenesulfonylamino)piperidine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0028
4-(4-but-2-enoylaminobenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.08
4-(4-cyanobenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000078
4-(6-acryloylaminopyridine-3-sulfonyl)piperazine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000097
4-(6-acryloylaminopyridine-3-sulfonyl)piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00038
4-[(4-acryloylaminobenzenesulfonylamino)methyl]-piperidine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0014
4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.08
4-[4-(2-cyanoacetylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.08
4-[4-(2-ethoxycarbonylvinyl)benzenesulfonyl]piperazine-1-carboxylic acid benzyl ester
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0023
4-[4-(2-fluoroacryloylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.08
4-[4-(2-methylacryloylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.08
4-[4-(2-methylbut-2-enoylamino)benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.08
4-[4-(2-oxopropionylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0068
4-[4-(3-(E)-chloroacryloylamino)benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00014
4-[4-(3-(Z)-chloroacryloylamino)benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.08
4-[4-(3-cyanomethylureido)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.016
4-[4-(3-diazo-2-oxopropyl)benzenesulfonyl]piperazine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.091
4-[4-(3-ethoxycarbonylallyl)benzenesulfonyl]piperazine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.01
4-[4-(4,4,4-trifluoro-3-methylbut-2-enoylamino)-benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
IC50 above 0.01 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.01
4-[4-(4,4,4-trifluorobut-2-enoylamino)benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
IC50 above 0.01 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.004
4-[4-(4-diazo-3-oxobutyl)benzenesulfonyl]piperazine-1-carboxylic acid benzyl ester
Homo sapiens
25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0045
4-[4-(acryloylmethyl-amino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.028 - 0.08
4-[4-(cyanomethylcarbamoyl)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
0.08
4-[4-(ethoxycarbonylmethylamino)benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.076
4-[4-acryloylamino-3-(isobutylmethylamino)-benzenesulfonyl]piperazine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.03
5,5'-methanediylbis(1H-indole-2,3-dione)
Homo sapiens
-
pH and temperature not specified in the publication
0.025
5,5'-oxybis(1H-indole-2,3-dione)
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
5-(4-acryloylaminobenzenesulfonyl)-2,5-diazabicyclo-[2.2.1]heptane-2-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00014
5-(4-acryloylaminobenzenesulfonyl)hexahydropyrrolo[3,4-c]pyrrole-2-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.03 - 0.04
6,6'-oxybis(1H-indole-2,3-dione)
Homo sapiens
-
pH and temperature not specified in the publication
0.005925
benzyl 4-[3-(acryloylamino)-2-oxopropanoyl]piperazine-1-carboxylate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.001725
benzyl 4-[3-[(ethenylsulfonyl)amino]-2-oxopropanoyl]piperazine-1-carboxylate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.000889
dimethyl[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]sulfonium
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.000775
dimethyl[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)ethyl]sulfonium
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.00315
dimethyl[2-oxo-2-[2-(tricyclo[3.3.1.13,7]dec-1-yl)ethoxy]ethyl]sulfonium
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.016
ethenesulfonic acid (4-bromophenyl)amide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0018
ethyl [(3E)-4-chloro-2-oxo-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-2,3-dihydro-1H-indol-1-yl]acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.025
fluorenylmethyl [4-[(1E)-3-(1H-benzotriazol-1-yl)-3-oxoprop-1-en-1-yl]phenyl]carbamate
Cavia porcellus
-
pH 7.0, 25
0.1
indirubin
Homo sapiens
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.0011
methyl 3-([(3E)-4-chloro-2-oxo-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-2,3-dihydro-1H-indol-1-yl]methyl)benzoate
Homo sapiens
-
pH and temperature not specified in the publication
0.0012
methyl 4-([(3E)-4-chloro-2-oxo-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-2,3-dihydro-1H-indol-1-yl]methyl)benzoate
Homo sapiens
-
pH and temperature not specified in the publication
0.027
methyl 4-[(1E)-3-(1H-benzotriazol-1-yl)-3-oxoprop-1-en-1-yl]benzoate
Cavia porcellus
-
pH 7.0, 25
0.0063
methyl 4-[(acryloyloxy)methyl]benzoate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0000021
methyl 4-[[(bromoacetyl)oxy]methyl]benzoate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0021
methyl 6-[(acryloyloxy)methyl]naphthalene-2-carboxylate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.000015
methyl 6-[[(bromoacetyl)oxy]methyl]naphthalene-2-carboxylate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.00000665
methyl 6-[[(chloroacetyl)oxy]methyl]naphthalene-2-carboxylate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.005
methyl N-[(benzyloxy)carbonyl]-L-phenylalanyl-6-(dimethylsulfonio)-5-oxo-L-norleucinate bromide
Homo sapiens
-
-
0.08
N-(2-bromophenyl)acrylamide
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0000061
N-(2-[4-[5-(dimethylamino)naphthalene-1-sulfonyl]piperazin-1-yl]-2-oxoethyl)prop-2-enamide
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.003
N-(3-bromophenyl)acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.043
N-(4-bromobenzyl)acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0033
N-(4-bromophenyl)acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.08
N-(4-bromophenyl)propionamide
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.029
N-(4-fluorophenyl)acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00013
N-(4-[4-[2-(2-phenoxyphenyl)acetyl]piperazine-1-sulfonyl]-phenyl)acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000054
N-(4-[4-[2-(3-phenoxyphenyl)acetyl]piperazine-1-sulfonyl]-phenyl)acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00006
N-(4-[4-[2-(4-phenoxyphenyl)acetyl]piperazine-1-sulfonyl]-phenyl)acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.11
N-(phenylcarbonyl)-L-phenylalanyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.3
N-(tert-butoxycarbonyl)-L-phenylalanyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.043
N-phenylacrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.008
N-[(2-phenylethoxy)carbonyl]-L-phenylalanyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.0002
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(6-phenylpyridin-2-yl)piperazin-1-yl]hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.00034
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-2-yl)piperazin-1-yl]hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.00009
N-[(5S)-6-oxo-5-(2-phenylacetamido)-6-[4-(pyridin-3-yl)piperazin-1-yl]hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.00022
N-[(5S)-6-[4-(6-bromopyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.00018
N-[(5S)-6-[4-(6-chloropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.00011
N-[(5S)-6-[4-(6-fluoropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.00014
N-[(5S)-6-[4-(6-iodopyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.00031
N-[(5S)-6-[4-(6-methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.0001
N-[(5S)-6-[4-(6-nitropyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.00017
N-[(5S)-6-[4-(6-tert-butylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.00039
N-[(5S)-6-[4-[6-(2-fluoroethoxy)pyridin-2-yl]piperazin-1-yl]-6-oxo-5-(2-phenylacetamido)hexyl]prop-2-enamide
Homo sapiens
pH 6.5, 30°C
0.03
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.02
N-[(benzyloxy)carbonyl]-L-alanyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.028
N-[(benzyloxy)carbonyl]-L-alpha-aspartyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.35
N-[(benzyloxy)carbonyl]-L-isoleucyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.003
N-[(benzyloxy)carbonyl]-L-phenylalanyl-5-oxo-6-[(1,3,4,5-tetramethyl-1H-imidazol-3-ium-2-yl)sulfanyl]-L-norleucine
Homo sapiens
-
-
0.02
N-[(benzyloxy)carbonyl]-L-phenylalanyl-6-(diethylsulfonio)-5-oxo-L-norleucine
Homo sapiens
-
-
0.01
N-[(benzyloxy)carbonyl]-L-phenylalanyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.012
N-[(benzyloxy)carbonyl]-L-tryptophyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.008
N-[(benzyloxy)carbonyl]glycyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.000032
N-[4-(4-cyclopentanecarbonylpiperazine-1-sulfonyl)-phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00011
N-[4-(4-cyclopropanecarbonylpiperazine-1-sulfonyl)-phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00018
N-[4-(4-phenylpiperazine-1-sulfonyl)phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000055
N-[4-(4-pyridin-2-ylpiperazine-1-sulfonyl)phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0057
N-[4-(aminomethyl)benzyl]-3-(5-[[[[(E)-2-phenylethenyl]sulfonyl](pyridin-2-ylmethyl)amino]methyl]-1,2,4-oxadiazol-3-yl)benzamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0013
N-[4-(piperazine-1-sulfonyl)phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0019
N-[4-(pyrrolidine-1-sulfonyl)phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.005
N-[4-methanesulfonylphenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.058
N-[4-methoxyphenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00067
N-[4-nitrophenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.026
N-[4-phenoxyphenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.045
N-[4-toluyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0038
N-[4-trifluoromethylphenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.028
N-[4-[(1E)-3-oxo-3-(pyridin-3-yl)prop-1-en-1-yl]phenyl]acetamide
Cavia porcellus
-
pH 7.0, 25
0.000034
N-[4-[4-(2-phenylcyclopropanecarbonyl)piperazine-1-sulfonyl]phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00019
N-[4-[4-(2-trifluoromethylphenyl)piperazine-1-sulfonyl]-phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000025
N-[4-[4-(3-methylpyridin-2-yl)piperazine-1-sulfonyl]phenyl]-acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00016
N-[4-[4-(3-phenylpropionyl)piperazine-1-sulfonyl]phenyl]-acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00038
N-[4-[4-(3-phenylpropyl)piperazine-1-sulfonyl]phenyl]-acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000052
N-[4-[4-(3-trifluoromethylpyridin-2-yl)piperazine-1-sulfonyl]phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000041
N-[4-[4-(4,4-difluoropiperidine-1-carbonyl)piperazine-1-sulfonyl]phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00031
N-[4-[4-(4-phenylbutyl)piperazine-1-sulfonyl]phenyl]-acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000035
N-[4-[4-(6-methylpyridin-2-yl)piperazine-1-sulfonyl]phenyl]-acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000076
N-[4-[4-(6-trifluoromethylpyridin-3-yl)piperazine-1-sulfonyl]phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00001
N-[4-[4-(adamantane-1-carbonyl)piperazine-1-sulfonyl]-phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00002
N-[4-[4-(octahydroisoquinoline-2-carbonyl)piperazine-1-sulfonyl]phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000026
N-[4-[4-(octahydroquinoline-1-carbonyl)piperazine-1-sulfonyl]phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000037
N-[4-[4-(piperidine-1-carbonyl)piperazine-1-sulfonyl]-phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000057
N-[4-[4-(pyrrolidine-1-carbonyl)piperazine-1-sulfonyl]-phenyl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00018
N-[5-(4-cyclopropanecarbonylpiperazine-1-sulfonyl)-pyridin-2-yl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000015
N-[5-[4-(adamantane-1-carbonyl)piperazine-1-sulfonyl]-pyridin-2-yl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000014
N-[5-[4-(adamantane-1-carbonyl)piperazine-1-sulfonyl]-pyrimidin-2-yl]acrylamide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.15
N2-[(benzyloxy)carbonyl]-L-lysyl-6-(dimethylsulfonio)-5-oxo-L-norleucine bromide
Homo sapiens
-
-
0.03
pyrrolidine-1-carboxylic acid (4-acryloylaminophenyl)-amide
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.018
tert-butyl [4-[(1E)-3-(1H-benzotriazol-1-yl)-3-oxoprop-1-en-1-yl]phenyl]carbamate
Cavia porcellus
-
pH 7.0, 25
0.00000629
tricyclo[3.3.1.13,7]dec-1-ylmethyl bromoacetate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.001625
tricyclo[3.3.1.13,7]dec-1-ylmethyl prop-2-enoate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.00021
[1-(4-acryloylaminobenzenesulfonyl)piperidin-4-ylmethyl]-carbamic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00022
[1-(4-acryloylaminobenzenesulfonyl)piperidin-4-yl]-carbamic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00038
[2-[(2-[4-[5-(dimethylamino)naphthalene-1-sulfonyl]piperazin-1-yl]-2-oxoethyl)amino]-2-oxoethyl](dimethyl)sulfanium
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.00185
[2-[(3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-2,3-dioxopropyl)amino]-2-oxoethyl](diethyl)sulfanium bromide
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0014
[2-[(3-[4-[(benzyloxy)carbonyl]piperazin-1-yl]-2,3-dioxopropyl)amino]-2-oxoethyl](dimethyl)sulfanium bromide
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0015
[2-[(4-acryloylaminobenzenesulfonyl)methylamino]ethyl]-methylcarbamic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.0029
[4-(4-acryloylpiperazine-1-sulfonyl)phenyl]carbamic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.08
[4-[(4-aminophenyl)sulfonyl]piperazin-1-yl](cyclopropyl)methanone
Homo sapiens
IC50 above 0.08 mM, in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00044
(naphthalen-2-yl)methyl 4-(N-acryloylglycyl)piperazine-1-carboxylate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.00107
(naphthalen-2-yl)methyl 4-(N-acryloylglycyl)piperazine-1-carboxylate
Homo sapiens
-
at pH 7.1, temperature not specified in the publication
0.0005
3-(4-acryloylaminobenzenesulfonylamino)-(R)-pyrrolidine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00058
3-(4-acryloylaminobenzenesulfonylamino)-(R)-pyrrolidine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.000096
3-(4-acryloylaminobenzenesulfonylamino)-(S)-pyrrolidine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.00052
3-(4-acryloylaminobenzenesulfonylamino)-(S)-pyrrolidine-1-carboxylic acid benzyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
0.028
4-[4-(cyanomethylcarbamoyl)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
Homo sapiens
in 25 mM HEPES, pH 7.4, 250 mM NaCl, 2 mM MgCl2, 10 mM CaCl2, 0.2 mM dithiothreitol, and 0.05% (v/v) Pluronic F-127 at 37°C
