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2.3.2.13: protein-glutamine gamma-glutamyltransferase

This is an abbreviated version!
For detailed information about protein-glutamine gamma-glutamyltransferase, go to the full flat file.

Word Map on EC 2.3.2.13

Reaction

protein glutamine
+
alkylamine
=
protein N5-alkylglutamine
 +
NH3

Synonyms

AcTG-1, BmTGA, chloroplast transglutaminase, chlTGase, cold active transglutaminase, cold-active transglutaminase, EPB42, factor XIII, factor XIIIa, fibrin stabilizing factor, fibrinoligase, Galphah, glutamine:amine gamma-glutamyl-transferase, glutaminylpeptide gamma-glutamyltransferase, glutamyltransferase, glutaminylpeptide gamma-, gpTGase 2, gTG2, hfXIIIa, hTG2, hTGase 1, hTGase 2, hTGase 3, hTGase 6, KALB, KalbTG, KALB_7456, Laki-Lorand factor, mammalian transglutaminase, microbial transglutaminase, microbial transglutaminases, MsTGase, MTG, MTG-TX, MTGase, mTGase 2, OlTGT, plastidial transglutaminase, polyamine transglutaminase, protein 4.2, protein-glutamine gamma-glutamyltransferase, R-glutaminyl-peptide:amine gamma-glutamyl transferase, R-glutaminylpeptide-amine gamma-glutamyltransferase, SCTG, SMTG, STG I, t-TG, TG-2, TG1, TG2, TG3, TG4, TG5, TG6, TG7, tGA, TGase, TGase 1, TGase 2, Tgase 3, TGase 6, Tgase II, TGase-2, TGase2, TGB, TGK1, TGK2, TGL, TGM1, TGM2, TGM3, TGM4, TGM5, TGM6, TGM7, TGZ, tgz15, TGZo, tissue transglutaminase, tissue transglutaminase 2, tissue-TG, transglutaminase, transglutaminase 1, transglutaminase 2, transglutaminase 3, transglutaminase 6, transglutaminase C, transglutaminase factor XIII, transglutaminase type II, transglutaminase-2, transglutaminase-like protein, transglutaminase2, tTG, tTG-2, type 2 transglutaminase, type I transglutaminase, type-2 transglutaminase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.13 protein-glutamine gamma-glutamyltransferase

KM Value

KM Value on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.014
Ac-PNPQLPF-OH
at pH 7.0 and 25°C
0.0029 - 0.0032
acetyl-alphaS1-casein
-
0.007
actin
-
platelet transglutaminase
2.1
alpha-difluoromethylornithine
-
-
2.1
alpha-difluoroornithine
-
suicide substrate
1.9
alpha2 plasmin inhibitor
at pH 7.5 and 37°C
-
7
benzyloxycarbonyl-L-glutaminylglycine
-
-
0.0409
beta-casein
-
-
-
66
carbobenzoxy-L-glutaminylglycine
-
-
0.006 - 0.012
casein
1.9
CBz-Gln-Ala
-
37°C, pH 7.0
3.2 - 5.9
CBz-Gln-Gly
9.4
CBz-Gln-Gly-Gly
-
37°C, pH 7.0
3.53 - 8.55
CBZ-Gln-Gly-OH
7
CBz-Gln-Leu
-
37°C, pH 7.0
2.7
CBZ-Gln-Phe
-
37°C, pH 7.0
2.9
CBz-Gln-Ser
-
37°C, pH 7.0
4.4
CBz-Gln-Val
-
37°C, pH 7.0
0.0019
Dansylcadaverine
-
pH 7.4, 30°C
0.0044 - 0.01
GTP
0.38 - 0.52
histamine
1.37 - 61.9
hydroxylamine
0.0037
involucrin
-
recombinant transglutaminase 5
2.9 - 15.8
L-lysine
1.43
LGPQSKVIG
-
37°C, pH 7.4
0.782
LGPQSLVIG
-
37°C, pH 7.4
0.0044
loricrin
-
recombinant transglutaminase 5
-
0.024 - 0.061
methylamine
0.01 - 0.034
Monodansylcadaverine
0.0176
N,N'-dimethyl casein glutamine
pH 7.5, 37°C, recombinant TG2 without DNAJA1
-
0.05
N,N'-dimethylcasein
-
-
-
0.017
N,N-dimethylcasein
-
pH 9.0, 37°C
-
0.011
N-acetyl-PNPQLPF
apparent value, 0.05 mM EDTA, 3.3 mM CaCl2, in 0.11 M MOPS at pH 7.0 and 25°C
0.05469 - 69.4
N-carboxybenzoyl-L-glutaminyl-glycine
40.47
N-carboxybenzoyl-L-glutaminylglycine
-
at pH 6.0 and 55°C
12.83 - 59.5
N-Cbz-Gln-Gly
23.12
N-CBZ-Glu-Gly
pH 6.0, 37°C
0.014
N-Cbz-L-glutaminyl(gamma-4-nitrophenylester)glycine
0.05 mM EDTA, 3.3 mM CaCl2, in 0.11 M MOPS at pH 7.0 and 25°C
0.0033
N-methyl-casein
-
pH 7.4, 30°C
-
11.2 - 30
Nalpha-benzyloxycarbonyl-L-Gln-Gly
52.66
Nalpha-benzyloxycarbonyl-L-glutaminylglycine
-
in 250 mM Tris acetate buffer (pH 8.0), at 37°C
1.28
NQENVSPLTLLKLGN
-
37°C, pH 7.4
0.208
NQENVSPLTLLRLGN
-
37°C, pH 7.4
0.459
NQEQVSPLTLLKLGN
-
37°C, pH 7.4
1.35
ornithine
-
-
0.00288 - 0.0203
pentylamine
0.035 - 9.63
putrescine
0.0077
small proline-rich protein 3
-
recombinant transglutaminase 5
-
0.0214 - 0.042
spermidine
0.0317 - 0.069
spermine
1.16 - 1.27
succinylated casein
-
1.8 - 11.6
Z-Gln-Gly
0.00253
Z-Glu(HC)-Gly-OH
pH 8.0, 30°C
0.0066
Z-Glu(HMC)-Gly-OH
pH 8.0, 30°C
0.00114
Z-Phe-gamma-Abu-7-hydroxy-4-methylcoumarin
pH 8.0, 30°C
0.00147
Z-Phe-gamma-Abu-7-hydroxycoumarin
pH 8.0, 30°C
additional information
additional information
-