2.3.2.20: cyclo(L-leucyl-L-phenylalanyl) synthase

This is an abbreviated version!
For detailed information about cyclo(L-leucyl-L-phenylalanyl) synthase, go to the full flat file.

Word Map on EC 2.3.2.20

2.3.2.20

cdpss

diketopiperazine

synthetases

aminoacylated

2,5-diketopiperazines

nonribosomal

trna-dependent

prenyltransferase

aa-trnas

aarss

class-i

nocardiopsis

prenylation

hijack

bond-forming

ping-pong

synthesis

tryptophan-containing

synthetase-like

noursei

Reaction

Synonyms

AlbC, BcmA, CDP, CDPS, CDPS 22, CDPS39, cFL synthase, cyclodipeptide synthase, cyclodipeptide synthases, Fdum-CDPS, Nbra-CDPS, NcdA, NCTC11370_02388, Ndas_1148, NozA, O3I_025450, Rgry-CDPS, RICGR_0139

ECTree

2 Transferases

2.3 Acyltransferases

2.3.2 Aminoacyltransferases

2.3.2.20 cyclo(L-leucyl-L-phenylalanyl) synthase

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Results	in table
5	AA Sequence
7	Application
7	Cloned(Commentary)
5	Crystallization (Commentary)
60	General Information
1	Inhibitors
15	Natural Substrates/ Products (Substrates)
28	Organism
1	PDB ID
19	Protein Variants
6	Purification (Commentary)
2	Reaction
28	Reference
31	Substrates and Products (Substrate)
92	Synonyms
1	Systematic Name

Reference

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Reference on EC 2.3.2.20 - cyclo(L-leucyl-L-phenylalanyl) synthase

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723244

Gondry, M.; Sauguet, L.; Belin, P.; Thai, R.; Amouroux, R.; Tellier, C.; Tuphile, K.; Jacquet, M.; Braud, S.; Courcon, M.; Masson, C.; Dubois, S.; Lautru, S.; Lecoq, A.; Hashimoto, S.; Genet, R.; Pernodet, J.L.

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes

Nat. Chem. Biol.

414-420

2009

Streptomyces noursei (Q8GED7), Streptomyces noursei

19430487

723291

Sauguet, L.; Moutiez, M.; Li, Y.; Belin, P.; Seguin, J.; Le Du, M.H.; Thai, R.; Masson, C.; Fonvielle, M.; Pernodet, J.L.; Charbonnier, J.B.; Gondry, M.

Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis

Nucleic Acids Res.

4475-4489

2011

Streptomyces noursei (Q8GED7), Streptomyces noursei

21296757

735351

James, E.D.; Knuckley, B.; Alqahtani, N.; Porwal, S.; Ban, J.; Karty, J.A.; Viswanathan, R.; Lane, A.L.

Two distinct cyclodipeptide synthases from a marine actinomycete catalyze biosynthesis of the same diketopiperazine natural product

ACS Synth. Biol.

547-553

2016

Nocardiopsis sp. CMB-M0232

26641496

736860

Jacques, I.; Moutiez, M.; Witwinowski, J.; Darbon, E.; Martel, C.; Seguin, J.; Favry, E.; Thai, R.; Lecoq, A.; Dubois, S.; Pernodet, J.; Gondry, M.; Belin, P.

Analysis of 51 cyclodipeptide synthases reveals the basis for substrate specificity

Nat. Chem. Biol.

721-727

2015

Streptomyces albulus, Bacillus sp. NSP9.1, Bacillus sp. 171095_106

26236937

736873

Moutiez, M.; Schmitt, E.; Seguin, J.; Thai, R.; Favry, E.; Belin, P.; Mechulam, Y.; Gondry, M.

Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases

Nature Commun.

5141

2014

Streptomyces noursei (Q8GED7)

25284085

736904

Moutiez, M.; Seguin, J.; Fonvielle, M.; Belin, P.; Jacques, I.B.; Favry, E.; Arthur, M.; Gondry, M.

Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei

Nucleic Acids Res.

7247-7258

2014

Streptomyces noursei

24782519

758643

Canu, N.; Belin, P.; Thai, R.; Correia, I.; Lequin, O.; Seguin, J.; Moutiez, M.; Gondry, M.

Incorporation of non-canonical amino acids into 2,5-diketopiperazines by cyclodipeptide synthases

Angew. Chem. Int. Ed. Engl.

3118-3122

2018

Rickettsiella massiliensis

29377457

758968

Skinnider, M.A.; Johnston, C.W.; Merwin, N.J.; Dejong, C.A.; Magarvey, N.A.

Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis

BMC Genomics

2018

Streptomyces noursei (Q8GED7)

29334896

759679

Bourgeois, G.; Seguin, J.; Babin, M.; Belin, P.; Moutiez, M.; Mechulam, Y.; Gondry, M.; Schmitt, E.

Structural basis for partition of the cyclodipeptide synthases into two subfamilies

J. Struct. Biol.

203

17-26

2018

Fluoribacter dumoffii (A0A377GCR9), Rickettsiella grylli (A8PKE0), Nocardia brasiliensis (K0F6G5), Streptomyces noursei (Q8GED7), Nocardia brasiliensis ATCC 700358 (K0F6G5), Rickettsiella grylli ATCC 700358 (A8PKE0)

29505829

759890

Borgman, P.; Lopez, R.; Lane, A.

The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

Org. Biomol. Chem.

2305-2314

2019

Pseudomonas aeruginosa, Nocardiopsis dassonvillei (D7B1W8), Streptomyces noursei (Q8GED7), Nocardiopsis dassonvillei NBRC 14626 (D7B1W8), Nocardiopsis dassonvillei JCM 7437 (D7B1W8), Nocardiopsis dassonvillei NRRL B-5397 (D7B1W8), Nocardiopsis dassonvillei DSM 43111 (D7B1W8), Nocardiopsis dassonvillei IMRU 509 (D7B1W8), Nocardiopsis dassonvillei CIP 107115 (D7B1W8), Nocardiopsis dassonvillei NCTC 10488 (D7B1W8), Nocardiopsis dassonvillei KCTC 9190 (D7B1W8)

30688950

760169

Schmitt, E.; Bourgeois, G.; Gondry, M.; Aleksandrov, A.

Cyclization reaction catalyzed by cyclodipeptide synthases relies on a conserved tyrosine residue

Sci. Rep.

7031

2018

Streptomyces noursei (Q8GED7)

29728603