2.3.2.20: cyclo(L-leucyl-L-phenylalanyl) synthase

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For detailed information about cyclo(L-leucyl-L-phenylalanyl) synthase, go to the full flat file.

Word Map on EC 2.3.2.20

2.3.2.20

cdpss

diketopiperazine

synthetases

aminoacylated

2,5-diketopiperazines

nonribosomal

trna-dependent

prenyltransferase

aa-trnas

aarss

class-i

nocardiopsis

prenylation

hijack

bond-forming

ping-pong

synthesis

tryptophan-containing

synthetase-like

noursei

Reaction

Synonyms

AlbC, BcmA, CDP, CDPS, CDPS 22, CDPS39, cFL synthase, cyclodipeptide synthase, cyclodipeptide synthases, Fdum-CDPS, Nbra-CDPS, NcdA, NCTC11370_02388, Ndas_1148, NozA, O3I_025450, Rgry-CDPS, RICGR_0139

ECTree

2 Transferases

2.3 Acyltransferases

2.3.2 Aminoacyltransferases

2.3.2.20 cyclo(L-leucyl-L-phenylalanyl) synthase

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Results	in table
5	AA Sequence
7	Application
7	Cloned(Commentary)
5	Crystallization (Commentary)
60	General Information
1	Inhibitors
15	Natural Substrates/ Products (Substrates)
28	Organism
1	PDB ID
19	Protein Variants
6	Purification (Commentary)
2	Reaction
28	Reference
31	Substrates and Products (Substrate)
92	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.2.20 - cyclo(L-leucyl-L-phenylalanyl) synthase

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L-leucyl-tRNALeu:L-phenylalanyl-tRNAPhe leucyltransferase (cyclizing)

The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue [2]. The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L-phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl-L-tyrosyl) [1].