2.3.2.21: cyclo(L-tyrosyl-L-tyrosyl) synthase

This is an abbreviated version!
For detailed information about cyclo(L-tyrosyl-L-tyrosyl) synthase, go to the full flat file.

Reaction

2 L-tyrosyl-tRNATyr = 2 tRNATyr +

Synonyms

CDPS, CDPS-Np, cyclo(L-tyrosyl-L-tyrosyl) synthase, cyclodipeptide synthase, cyclodityrosine synthetase, cYY synthase, Rv2275

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.21 cyclo(L-tyrosyl-L-tyrosyl) synthase

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Results	in table
2	AA Sequence
3	Application
2	Cloned(Commentary)
1	Crystallization (Commentary)
11	General Information
4	Natural Substrates/ Products (Substrates)
10	Organism
3	Pathway
8	Protein Variants
2	Purification (Commentary)
3	Reaction
8	Reference
12	Substrates and Products (Substrate)
25	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.3.2.21 - cyclo(L-tyrosyl-L-tyrosyl) synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2 L-tyrosyl-tRNALeu

2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)

Mycobacterium tuberculosis

-

-

723244

-

-

?

2 L-tyrosyl-tRNATyr

2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)

3 entries

2 L-tyrosyl-tRNATyr

tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)

Nocardiopsis prasina

-

-

759643

-

-

?

L-tyrosyl-tRNATyr + L-phenylalanyl-tRNAPhe

tRNATyr + tRNAPhe + cyclo(L-tyrosyl-L-phenylalanyl)

Nocardiopsis prasina

-

-

759643

-

-

?

additional information

?

-

5 entries

2 L-tyrosyl-tRNATyr

2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)

Mycobacterium tuberculosis

P9WPF9

-

723247, 759890

-

-

?

2 L-tyrosyl-tRNATyr

2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)

Mycobacterium tuberculosis H37Rv

P9WPF9

-

723247

-

-

?

2 L-tyrosyl-tRNATyr

2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)

Nocardiopsis prasina

-

-

759643

-

-

?

additional information

?

-

Mycobacterium tuberculosis

-

cyclodipeptides synthesized by gene product Rv2275 always contain L-tyrosine

723244

-

-

?

additional information

?

-

Mycobacterium tuberculosis

P9WPF9

Rv2275 is established as a CDPS that catalyzes formation of cyclo(L-tyrosyl-L-tyrosyl) as its major product, along with a handful of minor products containing tyrosine

759890

-

-

-

additional information

?

-

Mycobacterium tuberculosis

P9WPF9

cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNAs to catalyze the formation of two peptide bonds leading to cyclodipeptides. Catalytic mechanism, overview

759679

-

-

-

additional information

?

-

Mycobacterium tuberculosis ATCC 25618

P9WPF9

cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNAs to catalyze the formation of two peptide bonds leading to cyclodipeptides. Catalytic mechanism, overview

759679

-

-

-

additional information

?

-

Mycobacterium tuberculosis H37Rv

P9WPF9

cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNAs to catalyze the formation of two peptide bonds leading to cyclodipeptides. Catalytic mechanism, overview

759679

-

-

-