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2.3.2.21: cyclo(L-tyrosyl-L-tyrosyl) synthase

This is an abbreviated version!
For detailed information about cyclo(L-tyrosyl-L-tyrosyl) synthase, go to the full flat file.

Reaction

2 L-tyrosyl-tRNATyr = 2 tRNATyr +

cyclo(L-tyrosyl-L-tyrosyl)

Synonyms

CDPS, CDPS-Np, cyclo(L-tyrosyl-L-tyrosyl) synthase, cyclodipeptide synthase, cyclodityrosine synthetase, cYY synthase, Rv2275

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.21 cyclo(L-tyrosyl-L-tyrosyl) synthase

Systematic Name

Systematic Name on EC 2.3.2.21 - cyclo(L-tyrosyl-L-tyrosyl) synthase

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SYSTEMATIC NAME
IUBMB Comments
L-tyrosyl-tRNATyr:L-tyrosyl-tRNATyr tyrosyltransferase (cyclizing)
The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue [2]. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl) [1].