2.3.2.24: (E3-independent) E2 ubiquitin-conjugating enzyme

This is an abbreviated version!
For detailed information about (E3-independent) E2 ubiquitin-conjugating enzyme, go to the full flat file.

Reaction

Synonyms

arsenite-sensitive E2, biquitin carrier protein D4, biquitin-conjugating enzyme E2 T, CDC34, CLF_100482, E2 ubiquitin-conjugating enzyme, E2-230K, E2-EPF ubiquitin carrier protein, E2-EPF UCP, E2/E3 hybrid enzyme, E2230K, HIP2, N-terminus-conjugating E2, UB carrier protein (E2), Ubc1, Ubc3, UbcH10, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, UBE2G1, UBE2G2, UBE2H, UBE2K, UBE2L3, UBE2N, UBE2O, UBE2Q2, UBE2R1, UBE2R2, UBE2S, UBE2T, UBE2V1, UBE2V2, UBE2W, ubiquitin carrier protein A, ubiquitin carrier protein B, ubiquitin carrier protein C, ubiquitin carrier protein D1, ubiquitin carrier protein D2, ubiquitin carrier protein D3, Ubiquitin carrier protein E1, ubiquitin carrier protein E2, ubiquitin carrier protein E3, Ubiquitin carrier protein G1, Ubiquitin carrier protein G2, ubiquitin carrier protein H, Ubiquitin carrier protein L3, ubiquitin carrier protein N, Ubiquitin carrier protein Q2, ubiquitin carrier protein R2, ubiquitin carrier protein S, ubiquitin carrier protein T, ubiquitin carrier protein W, ubiquitin-conjugating enzyme E2, ubiquitin-conjugating enzyme E2 A, ubiquitin-conjugating enzyme E2 B, ubiquitin-conjugating enzyme E2 C, ubiquitin-conjugating enzyme E2 D1, ubiquitin-conjugating enzyme E2 D2, ubiquitin-conjugating enzyme E2 D3, ubiquitin-conjugating enzyme E2 D4, ubiquitin-conjugating enzyme E2 E1, ubiquitin-conjugating enzyme E2 E2, ubiquitin-conjugating enzyme E2 E3, ubiquitin-conjugating enzyme E2 G1, ubiquitin-conjugating enzyme E2 G2, ubiquitin-conjugating enzyme E2 H, ubiquitin-conjugating enzyme E2 K, ubiquitin-conjugating enzyme E2 L3, ubiquitin-conjugating enzyme E2 N, ubiquitin-conjugating enzyme E2 O, Ubiquitin-conjugating enzyme E2 Q2, ubiquitin-conjugating enzyme E2 R1, ubiquitin-conjugating enzyme E2 R2, ubiquitin-conjugating enzyme E2 S, ubiquitin-conjugating enzyme E2 variant 1, ubiquitin-conjugating enzyme E2 variant 2, ubiquitin-conjugating enzyme E2 W, ubiquitin-conjugating enzyme E2-25 kDa, ubiquitin-conjugating enzyme E2-CDC34

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme

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Results	in table
82	AA Sequence
2	Application
5	Cloned(Commentary)
190	Disease/ Diagnostics
18	General Information
5	Inhibitors
6	KM Value [mM]
5	Localization
3	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
40	Organism
1	Pathway
66	PDB ID
3	pH Optimum
1	pI Value
1	Posttranslational Modification
5	Protein Variants
3	Purification (Commentary)
24	Reaction
1	Reaction Type
14	Reference
10	Source Tissue
1	Specific Activity [micromol/min/mg]
58	Substrates and Products (Substrate)
5	Subunits
96	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
6	Turnover Number [1/s]

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Reference on EC 2.3.2.24 - (E3-independent) E2 ubiquitin-conjugating enzyme

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

724254

Klemperer, N.S.; Berleth, E.S.; Pickart, C.M.

A novel, arsenite-sensitive E2 of the ubiquitin pathway: purification and properties

Biochemistry

11

6035-6042

1989

Oryctolagus cuniculus

2550069

brenda

725413

David, Y.; Ziv, T.; Admon, A.; Navon, A.

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

J. Biol. Chem.

285

8595-8604

2010

Homo sapiens, Homo sapiens (O00762), Homo sapiens (P49427), Homo sapiens (P49459), Homo sapiens (P51668), Homo sapiens (P51965), Homo sapiens (P60604), Homo sapiens (P61077), Homo sapiens (P61086), Homo sapiens (P61088), Homo sapiens (P62253), Homo sapiens (P62256), Homo sapiens (P62837), Homo sapiens (P63146), Homo sapiens (P68036), Homo sapiens (Q13404), Homo sapiens (Q15819), Homo sapiens (Q16763), Homo sapiens (Q712K3), Homo sapiens (Q8WVN8), Homo sapiens (Q969T4), Homo sapiens (Q96B02), Homo sapiens (Q96LR5), Homo sapiens (Q9NPD8), Homo sapiens (Q9Y2X8)

20061386

brenda

728303

Hoeller, D.; Hecker, C.M.; Wagner, S.; Rogov, V.; Doetsch, V.; Dikic, I.

E3-independent monoubiquitination of ubiquitin-binding proteins

Mol. Cell

26

891-898

2007

Homo sapiens

17588522

brenda

733857

Shin, D.Y.; Lee, H.; Park, E.S.; Yoo, Y.J.

Assembly of different length of polyubiquitins on the catalytic cysteine of E2 enzymes without E3 ligase; a novel application of non-reduced/reduced 2-dimensional electrophoresis

FEBS Lett.

585

3959-3963

2011

Homo sapiens (O00762), Homo sapiens (P60604), Homo sapiens (P61086)

22079664

brenda

734117

Pickart, C.M.; Rose, I.A.

Functional heterogeneity of ubiquitin carrier proteins

J. Biol. Chem.

260

1573-1581

1985

Homo sapiens

2981864

brenda

734119

Haas, A.L.; Bright, P.M.; Jackson, V.E.

Functional diversity among putative E2 isozymes in the mechanism of ubiquitin-histone ligation

J. Biol. Chem.

263

13268-13275

1988

Oryctolagus cuniculus

2843516

brenda

734679

Pitluk, Z.W.; McDonough, M.; Sangan, P.; Gonda, D.K.

Novel CDC34 (UBC3) ubiquitin-conjugating enzyme mutants obtained by charge-to-alanine scanning mutagenesis

Mol. Cell. Biol.

15

1210-1219

1995

Saccharomyces cerevisiae

7862115

brenda

734838

Song, L.; Chen, S.; Yu, X.; Wu, Z.; Xu, J.; Yang, G.; Zheng, N.; Hu, X.; Guo, L.; Dai, J.; Xu, J.; Ji, C.; Gu, S.; Ying, K.

Molecular cloning and characterization of cDNA encoding a ubiquitin-conjugating enzyme from Clonorchis sinensis

Parasitol. Res.

94

227-232

2004

Clonorchis sinensis (Q5USN4)

15480785

brenda

735012

Cook, B.W.; Barber, K.R.; Shilton, B.H.; Shaw, G.S.

The HIP2-ubiquitin conjugate forms a non-compact monomeric thioester during di-ubiquitin synthesis

PLoS ONE

10

e0120318

2015

Saccharomyces cerevisiae (P21734), Homo sapiens (P61086)

25799589

brenda

759030

Stewart, M.D.; Ritterhoff, T.; Klevit, R.E.; Brzovic, P.S.

E2 enzymes more than just middle men

Cell Res.

26

423-440

2016

Homo sapiens (Q9C0C9)

27002219

brenda

759177

Ullah, K.; Zubia, E.; Narayan, M.; Yang, J.; Xu, G.

Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset

FEBS J.

286

2018-2034

2019

Homo sapiens (Q9C0C9), Homo sapiens

30468556

brenda

759488

Chen, S.; Yang, J.; Zhang, Y.; Duan, C.; Liu, Q.; Huang, Z.; Xu, Y.; Zhou, L.; Xu, G.

Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1

J. Biol. Chem.

293

11296-11309

2018

Homo sapiens (Q9C0C9), Homo sapiens

29871923

brenda

760018

Lim, J.; Shin, H.; Chung, K.; Kim, N.; Kim, J.; Jung, H.; Im, D.; Jung, C.

E2-EPF UCP possesses E3 ubiquitin ligase activity via its cysteine 118 residue

PLoS ONE

11

e0163710

2016

Homo sapiens (Q9C0C9)

27685940

brenda

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