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2.3.2.5: glutaminyl-peptide cyclotransferase

This is an abbreviated version!
For detailed information about glutaminyl-peptide cyclotransferase, go to the full flat file.

Word Map on EC 2.3.2.5

Reaction

L-glutaminyl-peptide
=
5-Oxoprolyl-peptide
 +
NH3

Synonyms

AtQC, cyclotransferase, glutaminyl-transfer ribonucleate, DromeQC, gamma-glutamylamine cyclotransferase, GGACT, glutamine cyclotransferase, glutaminyl cyclase, glutaminyl-peptide cyclotransferase-like protein, glutaminyl-tRNA cyclotransferase, golgi resident enzyme, Golgi resident glutaminyl cyclase, Golgi-resident enzyme, Golgi-resident glutaminyl cyclase, gQC, h-isoQC, h-QC, hQC, isoDromeQC, isoGlutaminyl cyclase, isoQC, PgQC, QC, QCT, Qpct, Qpct1, QPCTL, secretory glutaminyl cyclase, sQC, StQC

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.5 glutaminyl-peptide cyclotransferase

Turnover Number

Turnover Number on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.07
2-amino-5-(butan-2-ylamino)-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.061
2-amino-5-(cyclohexylamino)-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.045
2-amino-5-(cyclopropylamino)-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.068
2-amino-5-oxo-5-(propan-2-ylamino)pentanoic acid
-
pH and temperature not specified in the publication
0.17
2-amino-5-oxo-5-[(2-phenylethyl)amino]pentanoic acid
-
pH and temperature not specified in the publication
0.19
2-amino-5-[(2-methylbutyl)amino]-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.11
2-amino-5-[(2S)-butan-2-ylamino]-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.21
2-amino-5-[[(2S)-2-methylbutyl]amino]-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.00022
EFRH-NH2
-
at pH 6.5, 150000fold lower compared to Gln substrate
0.00042
EFRHHDSGYE-NH2
-
-
39.4
Gln 7-amido-4-methylcoumarin
-
pH 8.0, 30°C
41.4 - 55
Gln(3)-amyloid-beta peptide 3-11 amide
-
62
Gln(3)-amyloid-beta peptide 3-21 amide
-
pH 6.0, 30°C, 1% DMSO
-
40
Gln(3)-amyloid-beta peptide 3-40 amide
-
pH 6.0, 30°C, 1% DMSO
-
0.0019 - 5.4
Gln-2-naphthylamide
5.3
Gln-7-amido-4-methylcoumarin
-
pH 8.0, 30°C
1.27 - 69.8
Gln-Ala
60.5 - 74.6
Gln-Ala-Ala-Ala-Ala-NH2
76.3 - 83.2
Gln-Ala-Ala-NH2
55.3 - 78.5
Gln-Ala-Ala-Ser-Ala-Ala-NH2
29.8 - 49.2
Gln-Arg-Gly-Ile-NH2
29.6 - 48.9
Gln-Arg-Tyr-Phe-NH2
51.4 - 56.6
Gln-Asn-Gly-Ile-NH2
20.6
Gln-beta-naphthylamide
-
pH 8.0, 30°C
51.4
Gln-beta-naphthylamine
-
pH 8.0, 30°C
0.43 - 43.2
Gln-Gln
0.755
Gln-Gln-Gln
-
-
12.8
Gln-Gln-OH
-
30°C, recombinant enzyme, expressed in Pichia pastoris
41.4 - 52.9
Gln-Gln-Tyr-Phe-NH2
2.6 - 50.3
Gln-Glu
46 - 53.7
Gln-Glu-Ala-Ala-NH2
39 - 48.5
Gln-Glu-Ala-Phe-NH2
45.6 - 58.5
Gln-Glu-Asp-Leu-NH2
42.1 - 44.7
Gln-Glu-Tyr-Ala-NH2
45.1 - 53.6
Gln-Glu-Tyr-NH2
46 - 54.6
Gln-Glu-Tyr-Phe-NH2
0.368 - 45.8
Gln-Gly
4 - 41.7
Gln-Gly-Pro
83
Gln-His-Pro-NH2
-
30°C, recombinant enzyme, expressed in Pichia pastoris
55.4 - 75.9
Gln-His-Tyr-Phe-NH2
31.6 - 58.1
Gln-Lys-Arg-Leu-NH2
0.36 - 45.2
Gln-NH2
7.5 - 24.1
Gln-Phe-Ala
109 - 132
Gln-Phe-Ala-NH2
18.8 - 31.7
Gln-Pro-Tyr-Phe-NH2
52.8 - 64.9
Gln-Ser-Tyr-Phe-NH2
6.7 - 49.4
Gln-tert-butyl ester
47 - 151.8
Gln-Trp-Ala-NH2
94
Gln-Tyr
-
pH 8.0, 30°C
7.7 - 125
Gln-Tyr-Ala
125 - 220
Gln-Tyr-Ala-OH
17.2
Gln-Val
-
pH 8.0, 30°C
10
glucagon(3-29)
-
pH 6.0, 30°C, 1% DMSO
-
1.07 - 25
H-Gln-7-amido-4-methylcoumarin
16 - 37.7
H-Gln-Ala-OH
13.1 - 40
H-Gln-Asp-Glu-Leu-NH2
1.1 - 45
H-Gln-beta-naphthylamide
2.72 - 24
H-Gln-Gln-OH
11 - 64
H-Gln-Glu-Ala-Phe-NH2
2.65 - 38
H-Gln-Glu-OH
49
H-Gln-Glu-Tyr-Ala-NH2
pH 8.0, 30°C
6.9 - 50
H-Gln-Glu-Tyr-Phe-NH2
1.66 - 22
H-Gln-Gly-OH
4.02 - 32
H-Gln-Gly-Pro-OH
7 - 62
H-Gln-Lys-Arg-Leu-NH2
25 - 37
H-Gln-NH2
55 - 57
H-Gln-Phe-Ala-NH2
16 - 22
H-Gln-Phe-Ala-OH
44
H-Gln-Ser-Tyr-Phe-NH2
pH 8.0, 30°C
17.04
H-Gln-Tyr-Ala-OH
30°C, isoDromeQC
3.02 - 27
H-Gln-Val-Ala-OH
0.054
L-gamma-glutamyl-(+)-3-aminobutyric acid
-
pH and temperature not specified in the publication
0.21
L-gamma-glutamyl-(+)-3-aminoisobutyric acid
-
pH and temperature not specified in the publication
0.18
L-gamma-glutamyl-beta-alanine
-
pH and temperature not specified in the publication
0.038
L-gamma-glutamyl-ethylamine
-
pH and temperature not specified in the publication
0.02
L-gamma-glutamyl-methylamine
-
pH and temperature not specified in the publication
0.21
L-gamma-glutamyl-n-butylamine
-
pH and temperature not specified in the publication
0.23
L-gamma-glutamyl-n-propylamine
-
pH and temperature not specified in the publication
0.012
L-gamma-glutamyl-tert-butylamine
-
kcat less than 0.012 s-1, pH and temperature not specified in the publication
0.036
L-gamma-glutamylaniline
-
pH and temperature not specified in the publication
0.4
L-gamma-glutamylbenzylamine
-
pH and temperature not specified in the publication
0.076
L-gamma-glutamylcyclopentylamine
-
pH and temperature not specified in the publication
0.14
L-gamma-glutamylglycine
-
pH and temperature not specified in the publication
0.18
L-gamma-glutamylneohexylamine
-
pH and temperature not specified in the publication
0.035
L-gamma-glutamylneopentylamine
-
pH and temperature not specified in the publication
1.4 - 45
L-Gln-2-naphthylamide
0.45 - 25
L-Gln-7-amido-4-methylcoumarin
35.7 - 61.5
L-Gln-amide
2 - 32
L-Gln-Gly
15.7 - 32
L-Gln-Gly-L-Pro
30 - 42
L-Gln-L-Ala
34
L-Gln-L-Arg-Gly-L-Ile-NH2
pH 8.0, 30°C
68
L-Gln-L-Asn-Gly-L-Ile-NH2
pH 8.0, 30°C
13.1 - 40
L-Gln-L-Asp-L-Glu-L-Leu-NH2
0.27 - 32
L-Gln-L-Gln
0.021 - 30
L-Gln-L-Glu
14.9 - 64
L-Gln-L-Glu-L-Ala-L-Phe-NH2
49
L-Gln-L-Glu-L-Tyr-L-Ala-NH2
pH 8.0, 30°C
9.2 - 50
L-Gln-L-Glu-L-Tyr-L-Phe-NH2
20.6 - 62
L-Gln-L-Lys-L-Arg-L-Leu-NH2
55 - 57
L-Gln-L-Phe-L-Ala-NH2
44
L-Gln-L-Ser-L-Tyr-L-Phe-NH2
pH 8.0, 30°C
23
L-Gln-L-Thr-Gly-L-Ile-NH2
pH 8.0, 30°C
41
L-Gln-L-Trp-L-Ala-NH2
pH 8.0, 30°C
10.9 - 27
L-Gln-L-Val-L-Ala-NH2
25 - 37
L-Gln-NH2
21 - 128
L-Gln-tert-butyl ester
33
L-glutamine tert-butyl ester
-
-
8.8
L-glutaminyl 2-naphthylamide
at pH 8.0 and 25°C
18.8
L-glutaminyl-2-naphthylamide
-
30°C, recombinant enzyme, expressed in Pichia pastoris
5.4
L-glutaminyl-4-methylcoumarinylamide
-
30°C, recombinant enzyme, expressed in Pichia pastoris
1.07 - 7
L-glutaminyl-7-amido-4-methylcoumarin
3.4 - 17.48
L-glutaminyl-beta-naphthylamide
20 - 47.2
N1-naphthalen-2-yl-L-glutamamide
0.25
Nepsilon-(L-gamma-glutamyl)-D-lysine
-
pH and temperature not specified in the publication
0.2
Nepsilon-(L-gamma-glutamyl)-L-lysine
-
pH and temperature not specified in the publication
12
O-(n-butylcarbamyl)-L-serine
-
pH and temperature not specified in the publication
0.054 - 40
QAAE
0.00008 - 183
QAAF
170
QAAR
in 0.1 M MES, pH 7.5, temperature not specified in the publication
0.0042 - 40
QAEA
0.0064 - 102
QAFA
0.0032 - 129
QARA
0.007 - 17.9
QEAA
6.4
QEDL
3.3 - 11.78
QEYF
0.084 - 60
QFAA
30 - 56
QFRH-NH2
0.012 - 1.1
QGGG
0.0074 - 66
QRAA
0.26
S-(cyclohexylamine)-L-cysteine
-
pH and temperature not specified in the publication
0.27
S-(n-butylcarbamyl)-L-cysteine
-
pH and temperature not specified in the publication
0.24
S-(n-propylcarbamyl)-L-cysteine
-
pH and temperature not specified in the publication
37.7 - 69.6
[Gln1]-fertilization promoting peptide
-
31.6 - 54.1
[Gln1]-gastrin
-
69.2 - 72.4
[Gln1]-gonadotropin releasing-hormone
-
37.7 - 48.8
[Gln1]-neurotensin
82.8
[Gln1]-thyrotropin releasing-hormone
-
pH 8.0, 30°C
-