2.3.2.5: glutaminyl-peptide cyclotransferase

This is an abbreviated version!
For detailed information about glutaminyl-peptide cyclotransferase, go to the full flat file.

Reaction

Synonyms

AtQC, cyclotransferase, glutaminyl-transfer ribonucleate, DromeQC, gamma-glutamylamine cyclotransferase, GGACT, glutamine cyclotransferase, glutaminyl cyclase, glutaminyl-peptide cyclotransferase-like protein, glutaminyl-tRNA cyclotransferase, golgi resident enzyme, Golgi resident glutaminyl cyclase, Golgi-resident enzyme, Golgi-resident glutaminyl cyclase, gQC, h-isoQC, h-QC, hQC, isoDromeQC, isoGlutaminyl cyclase, isoQC, PgQC, QC, QCT, Qpct, Qpct1, QPCTL, secretory glutaminyl cyclase, sQC, StQC

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.5 glutaminyl-peptide cyclotransferase

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Results	in table
3	Activating Compound
2659	AA Sequence
13	Application
1	CAS Registry Number
40	Cloned(Commentary)
19	Crystallization (Commentary)
171	Disease/ Diagnostics
2	Expression
34	General Information
4	General Stability
49	IC50 Value
377	Inhibitors
142	kcat/KM [mM/s]
211	Ki Value [mM]
343	KM Value [mM]
36	Localization
29	Metals/Ions
22	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
107	Organism
1	Pathway
103	PDB ID
21	pH Optimum
3	pH Range
12	pH Stability
19	Posttranslational Modification
76	Protein Variants
29	Purification (Commentary)
3	Reaction
2	Reaction Type
98	Reference
140	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
464	Substrates and Products (Substrate)
15	Subunits
129	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Temperature Stability [°C]
326	Turnover Number [1/s]

pH Stability

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pH Stability on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3.5 - 9

Xanthomonas campestris

Q8P8M4

the enzyme possesses relatively high activities between pH 5.0 and 7.5, but exhibits significantly decreased activities above pH 8.0 and below pH 5.0

720244

4

Carica papaya

-

30°C, 30 min, about 10% loss of activity

658233

5 - 6

Carica papaya

-

30°C, 30 min, about 30% loss of activity

658233

5.5

Homo sapiens

-

30°C, 30 min, about 70% loss of activity

658233

5.5 - 9

Mus musculus

Q9CYK2

stable for at least 30 min at 30°C, both native and recombinant enzyme. At pH values below or above, rapid inactivation. 0.02 mM ZnSO4 partially prevents denaturation in the acidic range

671982

6

Homo sapiens

-

30°C, 30 min, about 50% loss of activity

658233

6.5

Homo sapiens

-

30°C, 30 min, about 40% loss of activity

658233

6.5 - 8

Carica papaya

-

30°C, 30 min, about 10% loss of activity

658233

7 - 9

Homo sapiens

-

30°C, 30 min, less than 20% loss of activity

658233

8.5

Carica papaya

-

30°C, 30 min, about 20% loss of activity

658233

9 - 10

Carica papaya

-

30°C, 30 min, about 15% loss of activity

658233

9.5

Homo sapiens

-

30°C, 30 min, about 50% loss of activity

658233