2.3.2.8: arginyltransferase
This is an abbreviated version!
For detailed information about arginyltransferase, go to the full flat file.
Word Map on EC 2.3.2.8
-
2.3.2.8
-
arginylation
-
2.5.1.18
-
rx:glutathione
-
rx
-
n-degrons
-
polyubiquitylates
-
medicine
-
agriculture
- 2.3.2.8
-
arginylation
-
2.5.1.18
-
rx:glutathione
- rx
-
n-degrons
-
polyubiquitylates
- medicine
- agriculture
Reaction
Synonyms
Arg-transferase, Arg-tRNA transferase, Arg-tRNA-protein transferase, Arg-tRNA-proteintransferase, arginyl transferase, arginyl tRNA transferase, arginyl-transfer ribonucleate-protein aminoacyltransferase, arginyl-transfer ribonucleate-protein transferase, arginyl-transferase, arginyl-tRNA protein transferase, arginyl-tRNA--protein transferase, arginyl-tRNA--protein transferase 1, arginyl-tRNA-protein transferase, arginyl-tRNA-protein transferase 1, arginyl-tRNA:protein arginyltransferase, arginyltransferase, arginyltransferase 1, ATE, Ate1, ATE1-1, ATE1-2, Ate1-3, Ate1-4, ATE1-encoded R-transferase, DdAte1, L-arginyltransferase, R-transferase
ECTree
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Reference on EC 2.3.2.8 - arginyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Deutch, C.E.
Aminoacyl-tRNA: protein transferases
Methods Enzymol.
106
198-205
1984
Oryctolagus cuniculus
Soffer, R.L.; Horinishi, H.
Enzymic modification of proteins. I. General characteristics of the arginine-transfer reaction in rabbit liver cytoplasm
J. Mol. Biol.
43
163-175
1969
Oryctolagus cuniculus
Soffer, R.L.
Enzymatic modification of proteins. II. Purification and properties of the arginyl transfer ribonucleic acid-protein transferase from rabbit liver cytoplasm
J. Biol. Chem.
245
731-737
1970
Oryctolagus cuniculus
Soffer, R.L.
Peptide acceptors in the arginine transfer reaction
J. Biol. Chem.
248
2918-2921
1973
Oryctolagus cuniculus
Kato, M.
Heparin as an inhibitor of L-arginyl-tRNA: protein arginyltransferase
J. Biochem.
94
2015-2022
1983
Saccharomyces cerevisiae, Rattus norvegicus, Sus scrofa
Kato, M.; Nozawa, Y.
Complete purification of arginyl-tRNA:protein arginyltransferase from hog kidney and production of its antibody
Anal. Biochem.
143
361-367
1984
Sus scrofa
Ciechanover, A.; Ferber, S.; Ganoth, D.; Elias, S.; Avram, H.; Arfin, S.
Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway
J. Biol. Chem.
263
11155-11167
1988
Oryctolagus cuniculus
Soffer, R.L.
The arginine transfer reaction
Biochim. Biophys. Acta
155
228-240
1968
Ovis aries
Kaji, H.
Amino-terminal arginylation of chromosomal proteins by arginyl-tRNA
Biochemistry
15
5121-5125
1976
Mus musculus, Mus musculus BALB/c
Kaji, H.; Novelli, G.D.; Kaji, A.
A soluble amino acid incorporation system from rat liver
Biochim. Biophys. Acta
76
474-477
1963
Rattus norvegicus
Kwon, Y.T.; Kashina, A.S.; Davydov, I.V.; Hu, R.G.; An, J.Y.; Seo, J.W.; Du, F.; Varshavsky, A.
An essential role of N-terminal arginylation in cardiovascular development
Science
297
96-99
2002
Mus musculus
Kwon, Y.T.; Kashina, A.S.; Varshavsky, A.
Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway
Mol. Cell. Biol.
19
182-193
1999
Homo sapiens (O95260), Homo sapiens, Mus musculus (Q9Z2A5), Mus musculus
Li, J.; Pickart, C.M.
Inactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: Identification of residues proximal to the arsenoxide site
Biochemistry
34
139-147
1995
Saccharomyces cerevisiae
Takao, K.; Samejima, K.
Arginyl-tRNA-protein transferase activities in crude supernatants of rat tissues
Biol. Pharm. Bull.
22
1007-1009
1999
Rattus norvegicus
Takao, K.; Xu, Y.J.; Samejima, K.; Shirahata, A.; Nitsu, M.
Preparation and usefulness of some fluorogenic substrates for assay of arginyl-tRNA-Protein transferase by HPLC
Anal. Biochem.
267
373-381
1999
Sus scrofa
Yoshida, S.; Ito, M.; Callis, J.; Nishida, I.; Watanabe, A.
A delayed leaf senescence mutant is defective in arginyl-tRNA: protein arginyltransferase, a component of the N-end rule pathway in Arabidopsis
Plant J.
32
129-137
2002
Arabidopsis thaliana
Barker, C.R.; Mouchel, N.A.; Jenkins, J.R.
The identification and characterisation of a functional interaction between arginyl-tRNA-protein transferase and topoisomerase II
Biochem. Biophys. Res. Commun.
342
596-604
2006
Saccharomyces cerevisiae
Rai, R.; Mushegian, A.; Makarova, K.; Kashina, A.
Molecular dissection of arginyltransferases guided by similarity to bacterial peptidoglycan synthases
EMBO Rep.
7
800-805
2006
Mus musculus
Hu, R.G.; Brower, C.S.; Wang, H.; Davydov, I.V.; Sheng, J.; Zhou, J.; Kwon, Y.T.; Varshavsky, A.
Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms
J. Biol. Chem.
281
32559-32573
2006
Mus musculus
Decca, M.B.; Bosc, C.; Luche, S.; Brugiere, S.; Job, D.; Rabilloud, T.; Garin, J.; Hallak, M.E.
Protein arginylation in rat brain cytosol: a proteomic analysis
Neurochem. Res.
31
401-409
2006
Rattus norvegicus
Rai, R.; Kashina, A.
Identification of mammalian arginyltransferases that modify a specific subset of protein substrates
Proc. Natl. Acad. Sci. USA
102
10123-10128
2005
Mus musculus
Rai, R.; Wong, C.C.; Xu, T.; Leu, N.A.; Dong, D.W.; Guo, C.; McLaughlin, K.J.; Yates, J.R.; Kashina, A.
Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development
Development
135
3881-3889
2008
Mus musculus (Q9Z2A5), Mus musculus
Leu, N.A.; Kurosaka, S.; Kashina, A.
Conditional Tek promoter-driven deletion of arginyltransferase in the germ line causes defects in gametogenesis and early embryonic lethality in mice
PLoS ONE
4
e7734
2009
Mus musculus (Q9Z2A5), Mus musculus
Brower, C.S.; Varshavsky, A.
Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations
PLoS ONE
4
e7757
2009
Mus musculus (Q9Z2A5), Mus musculus
Hu, R.; Wang, H.; Xia, Z.; Varshavsky, A.
The N-end rule pathway is a sensor of heme
Proc. Natl. Acad. Sci. USA
105
76-81
2008
Saccharomyces cerevisiae, Mus musculus
Holman, T.J.; Jones, P.D.; Russell, L.; Medhurst, A.; Ubeda Tomas, S.; Talloji, P.; Marquez, J.; Schmuths, H.; Tung, S.A.; Taylor, I.; Footitt, S.; Bachmair, A.; Theodoulou, F.L.; Holdsworth, M.J.
The N-end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis
Proc. Natl. Acad. Sci. USA
106
4549-4554
2009
Arabidopsis thaliana (Q9ZT48), Arabidopsis thaliana
Saha, S.; Wang, J.; Buckley, B.; Wang, Q.; Lilly, B.; Chernov, M.; Kashina, A.
Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesis
Biochem. Pharmacol.
83
866-873
2012
Mus musculus
Wang, J.; Han, X.; Saha, S.; Xu, T.; Rai, R.; Zhang, F.; Wolf, Y.I.; Wolfson, A.; Yates, J.R.; Kashina, A.
Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo
Chem. Biol.
18
121-130
2011
Mus musculus
Wang, J.; Han, X.; Wong, C.C.; Cheng, H.; Aslanian, A.; Xu, T.; Leavis, P.; Roder, H.; Hedstrom, L.; Yates, J.R.; Kashina, A.
Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo
Chem. Biol.
21
331-337
2014
Mus musculus
Carpio, M.A.; Decca, M.B.; Lopez Sambrooks, C.; Durand, E.S.; Montich, G.G.; Hallak, M.E.
Calreticulin-dimerization induced by post-translational arginylation is critical for stress granules scaffolding
Int. J. Biochem. Cell Biol.
45
1223-1235
2013
Mus musculus
Ribeiro, P.A.; Ribeiro, J.P.; Minozzo, F.C.; Pavlov, I.; Leu, N.A.; Kurosaka, S.; Kashina, A.; Rassier, D.E.
Contractility of myofibrils from the heart and diaphragm muscles measured with atomic force cantilevers: effects of heart-specific deletion of arginyl-tRNA-protein transferase
Int. J. Cardiol.
168
3564-3571
2013
Mus musculus
Cha-Molstad, H.; Sung, K.S.; Hwang, J.; Kim, K.A.; Yu, J.E.; Yoo, Y.D.; Jang, J.M.; Han, D.H.; Molstad, M.; Kim, J.G.; Lee, Y.J.; Zakrzewska, A.; Kim, S.H.; Kim, S.T.; Kim, S.Y.; Lee, H.G.; Soung, N.K.; Ahn, J.S.; Ciechanover, A.; Kim, B.Y.; Kwon, Y.T.
Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding
Nat. Cell Biol.
17
917-929
2015
Mus musculus
Schuessele, C.; Hoernstein, S.N.; Mueller, S.J.; Rodriguez-Franco, M.; Lorenz, T.; Lang, D.; Igloi, G.L.; Reski, R.
Spatio-temporal patterning of arginyl-tRNA protein transferase (ATE) contributes to gametophytic development in a moss
New Phytol.
209
1014-1027
2016
Physcomitrium patens
Rai, R.; Zhang, F.; Colavita, K.; Leu, N.A.; Kurosaka, S.; Kumar, A.; Birnbaum, M.D.; Gyorffy, B.; Dong, D.W.; Shtutman, M.; Kashina, A.
Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers
Oncogene
35
4058-4068
2016
Homo sapiens
Brower, C.S.; Rosen, C.E.; Jones, R.H.; Wadas, B.C.; Piatkov, K.I.; Varshavsky, A.
Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats
Proc. Natl. Acad. Sci. USA
111
E4936-E4945
2014
Mus musculus
Jiang, Y.; Lee, J.; Lee, J.; Lee, J.; Kim, J.; Choi, W.; Yoo, Y.; Cha-Molstad, H.; Kim, B.; Kwon, Y.; Noh, S.; Kim, K.; Lee, M.
The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins
Autophagy
12
2197-2212
2016
Homo sapiens (O95260), Mus musculus (Q9Z2A5)
Kim, E.; Kim, S.; Lee, J.H.; Kwon, Y.T.; Lee, M.J.
Ablation of Arg-tRNA-protein transferases results in defective neural tube development
BMB Rep.
49
443-448
2016
Mus musculus (Q9Z2A5), Mus musculus 129SvEv/C57BL/6 (Q9Z2A5)
Kumar, A.; Birnbaum, M.; Patel, D.; Morgan, W.; Singh, J.; Barrientos, A.; Zhang, F.
Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response
Cell Death Dis.
7
e2378
2016
Homo sapiens (O95260), Homo sapiens, Mus musculus (Q9Z2A5), Mus musculus, Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Wang, J.; Pavlyk, I.; Vedula, P.; Sterling, S.; Leu, N.A.; Dong, D.W.; Kashina, A.
Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development
Dev. Biol.
430
41-51
2017
Mus musculus (Q9Z2A5), Mus musculus
Domitrovic, T.; Fausto, A.; Silva, T.; Romanel, E.; Vaslin, M.
Plant arginyltransferases (ATEs)
Genet. Mol. Biol.
40
253-260
2017
Physcomitrium patens (A0A2K1KVV8), Populus trichocarpa (A0A2K1YWL5), Chlamydomonas reinhardtii (A0A2K3D0B7), Vitis vinifera (A0A438HA55), Sorghum bicolor (C5YYU0), Oryza sativa Japonica Group (Q688J5), Arabidopsis thaliana (Q9ZT48)
Batsios, P.; Ishikawa-Ankerhold, H.C.; Roth, H.; Schleicher, M.; Wong, C.C.L.; Mueller-Taubenberger, A.
Ate1-mediated posttranslational arginylation affects substrate adhesion and cell migration in Dictyostelium discoideum
Mol. Biol. Cell
30
453-466
2019
Dictyostelium discoideum (Q55EI0), Dictyostelium discoideum, Dictyostelium discoideum AX2-214 (Q55EI0)
Hoernstein, S.N.; Mueller, S.J.; Fiedler, K.; Schuelke, M.; Vanselow, J.T.; Schuessele, C.; Lang, D.; Nitschke, R.; Igloi, G.L.; Schlosser, A.; Reski, R.
Identification of targets and interaction partners of arginyl-tRNA protein transferase in the moss Physcomitrella patens
Mol. Cell. Proteomics
15
1808-1822
2016
Physcomitrium patens (A0A2K1KVV8), Physcomitrium patens
White, M.D.; Klecker, M.; Hopkinson, R.J.; Weits, D.A.; Mueller, C.; Naumann, C.; O'Neill, R.; Wickens, J.; Yang, J.; Brooks-Bartlett, J.C.; Garman, E.F.; Grossmann, T.N.; Dissmeyer, N.; Flashman, E.
Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets
Nat. Commun.
8
14690
2017
Arabidopsis thaliana (Q9ZT48)
Singh, K.; Gupta, A.; Sarkar, A.; Gupta, I.; Rana, S.; Sarkar, S.; Khan, S.
Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway
Sci. Rep.
10
598
2020
Rattus norvegicus
Wang, J.; Han, X.; Leu, N.A.; Sterling, S.; Kurosaka, S.; Fina, M.; Lee, V.M.; Dong, D.W.; Yates, J.R.; Kashina, A.
Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration
Sci. Rep.
7
11323
2017
Mus musculus (Q9Z2A5), Mus musculus
Wang, J.; Pejaver, V.R.; Dann, G.P.; Wolf, M.Y.; Kellis, M.; Huang, Y.; Garcia, B.A.; Radivojac, P.; Kashina, A.
Target site specificity and in vivo complexity of the mammalian arginylome
Sci. Rep.
8
16177
2018
Mus musculus (Q9Z2A5), Mus musculus
Shim, S.M.; Choi, H.R.; Sung, K.W.; Lee, Y.J.; Kim, S.T.; Kim, D.; Mun, S.R.; Hwang, J.; Cha-Molstad, H.; Ciechanover, A.; Kim, B.Y.; Kwon, Y.T.
The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation
Sci. Signal.
11
eaan0630
2018
Homo sapiens (O95260)
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