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2.3.3.1: citrate (Si)-synthase

This is an abbreviated version!
For detailed information about citrate (Si)-synthase, go to the full flat file.

Word Map on EC 2.3.3.1

Reaction

acetyl-CoA
+
H2O
 +
oxaloacetate
=
citrate
 +
CoA

Synonyms

(R)-citric synthase, citrate oxaloacetate-lyase ((pro-3S)-CH2COO---> acetyl-CoA), citrate synthase, citrate synthase isoform a, citrate synthase isoform b, CLO1313_RS02945, CS, EC 4.1.3.7, HCS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.1 citrate (Si)-synthase

Expression

Expression on EC 2.3.3.1 - citrate (Si)-synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
acute administration of olanzapine inhibits citrate synthase activity in cerebellum and prefrontal cortex
-
Al3+ increases the expression level of citrate synthase gene and enzyme activity
-
AlCl3 treatment
-
during sexual development, the expression of citrate synthase is quite strong in cleistothecial shells. Acetate shows a strong inductive effect on citA expression, which is subjected to carbon catabolite repression caused by glucose
during sexual development, the expression of citrate synthase is significantly weak in the content of cleistothecia including ascospores
expression is regulated by catabolite control protein C (CcpC)
-
in AlCl3 containing growth edium
-
oanzapine 3 mg/kg and fluoxetine 12.5 mg/kg in combination increase citrate synthase activity in prefrontal cortex, hippocampus and striatum. The chronic administration of olanzapine increases citrate synthase activity in prefrontal cortex, hippocampus and striatum and fluoxetine increases citrate synthase activity in striatum
-
overexpression of retinoic acid receptor-related orphan receptor alpha (5fold), leads to a 94% increase in citrate synthase mRNA levels and enzyme activity in Hep-G2 cells
-
the mRNA expression of citrate synthase in liver is reduced by 42% in the staggerer mice (which possess a nonfunctional retinoic acid receptor-related orphan receptor alpha protein) relative to the wild type mice
-