Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.3.3.1: citrate (Si)-synthase

This is an abbreviated version!
For detailed information about citrate (Si)-synthase, go to the full flat file.

Word Map on EC 2.3.3.1

Reaction

acetyl-CoA
+
H2O
+
oxaloacetate
=
citrate
+
CoA

Synonyms

(R)-citric synthase, citrate oxaloacetate-lyase ((pro-3S)-CH2COO---> acetyl-CoA), citrate synthase, citrate synthase isoform a, citrate synthase isoform b, CLO1313_RS02945, CS, EC 4.1.3.7, HCS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.1 citrate (Si)-synthase

Inhibitors

Inhibitors on EC 2.3.3.1 - citrate (Si)-synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxoglutarate
-
no inhibition
3,3-thiodipropionate
substrate acetyl-CoA, competitive; substrate oxaloacetate, competitive
3,3-thiodipropionic acid
competitive inhibition versus acetyl-CoA and versus oxaloacetate
3-phosphonopropionic acid
competitive inhibition versus acetyl-CoA and versus oxaloacetate
3-phosphopropionate
substrate acetyl-CoA, competitive; substrate oxaloacetate, competitive
amphetamine
-
valproate reverses and lithium prevents the enzyme inhibition
D-serine
-
-
Dihydroxyfumarate
substrate acetyl-CoA, competitive; substrate oxaloacetate, competitive
dihydroxyfumaric acid
competitive inhibition versus acetyl-CoA and versus oxaloacetate
DL-malate
substrate acetyl-CoA, mixed type inhibition; substrate oxaloacetate, mixed type inhibition
DL-malic acid
mixed type inhibition versus acetyl-CoA and versus oxaloacetate
Maleate
substrate acetyl-CoA, mixed type inhibition; substrate oxaloacetate, mixed type inhibition
Maleic acid
mixed type inhibition versus acetyl-CoA and versus oxaloacetate
Ouabain
-
activity was inhibited immediately after the administration of ouabain in the prefrontal cortex at the doses of 0.01 mM and 0.1 mM
potassium hydroxycitrate
competitive inhibition versus acetyl-CoA and versus oxaloacetate; substrate acetyl-CoA, competitive; substrate oxaloacetate, competitive
propionate
competitive inhibition versus oxaloacetate, mixed type inhibition versus acetyl-CoA; substrate acetyl-CoA, competitive; substrate oxaloacetate, competitive
SDS
-
strong inhibition