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2.3.3.10: hydroxymethylglutaryl-CoA synthase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA synthase, go to the full flat file.

Word Map on EC 2.3.3.10

Reaction

acetyl-CoA
+
H2O
 +
acetoacetyl-CoA
=
(S)-3-hydroxy-3-methylglutaryl-CoA
 +
CoA

Synonyms

(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase I, 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-CoA synthase 1, 3-hydroxy-3-methylglutaryl-CoA synthase 2, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl_coenzyme A synthase, 3-hydroxyl-3-methyl-glutaryl-CoA synthase, acetoacetyl coenzyme A transacetase, beta-hydroxy-beta-methylglutaryl-CoA synthase, BjHMGS1, BjHMGS2, BjHMGS3, BjHMGS4, EC 4.1.3.5, GbHMGS2, GhHMGS1A, GhHMGS1D, GhHMGS2D, GhHMGS3A, GhHMGS3D, HGMS, HMG-CoA, HMG-CoA synthase, HMG-CoA synthase 1, HMG-CoS synthase, HMGCS, HMGCS1, HMGCS2, HMGS, HMGS-2, HMGS1, HMGS2, hydroxy-methylglutaryl coenzyme-A synthase, hydroxymethylglutaryl CoA synthase 2, hydroxymethylglutaryl CoA synthetase, hydroxymethylglutaryl coenzyme A synthase, hydroxymethylglutaryl coenzyme A-condensing enzyme, hydroxymethylglutaryl-CoA synthase, hydroxymethylglutaryl-coenzyme A synthase, LcHMGS, mvaS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.10 hydroxymethylglutaryl-CoA synthase

Expression

Expression on EC 2.3.3.10 - hydroxymethylglutaryl-CoA synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
3-hydroxy-3-methylglutaryl-CoA synthase 2 has significantly decreased levels of reduced thiols and activity after acetaminophen treatment
expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase can be upregulated by exogenous elicitors, including methyl jasmonate and salicylic acid, suggesting that CnHMGS is elicitor-responsive
GhHMGS1A and GhHMGS1D are strongly induced by gibberellin, auxin, and salicylic acid treatments, but are up-regulated by methyl jasmonate to varying degrees. The expression level of GhHMGS1A increases over time following the methyl jasmonate treatment, but GhHMGS1D expression peaks at 0.5 h after the methyl jasmonate treatment and then decreases to the control level, followed by another increase. GhHMGS2D is induced by all phytohormone treatments to varying extents. GhHMGS2D is strongly induced by salicylic acid and is only slightly up-regulated under the gibberellin and auxin treatment. In response to methyl jasmonate, the transcript level of GhHMGS2D undergoes relatively minimal changes during the initial time points but is significantly increased at 5 h. GhHMGS3A and GhHMGS3D are strongly induced by all four phytohormone treatments. Their expression profiles are very similar, although GhHMGS3A expression is up-regulated after the auxin treatment, whereas GhHMGS3D expression peaks at 3 h and then decreased slightly. Both GhHMGS1A and GhHMGS1D are induced by salt stress. Under the drought stress conditions simulated by 20% PEG, GhHMGS1D expression is slightly up-regulated at 6 h before decreasing slightly. When seedlings are exposed to 4°C for up to 12 h, GhHMGS1D expression is down-regulated during the first 6 h but is slightly up-regulated at 12 h. GhHMGS2D is induced by all salt, drought, cold, and heat stresses. The expression levels of both GhHMGS3A and GhHMGS3D are significantly up-regulated under salt stress. In response to simulated drought stress (20% PEG), GhHMGS3A expression is unaffected at the early time points but is upregulated at 6 h. GhHMGS3D expression is slightly upregulated throughout the imposed drought conditions. The cold stress treatment decreases the GhHMGS3A expression level during the first 6 h but increases it at 12 h. In response to heat stress, GhHMGS3A and GhHMGS3D exhibit similar up-regulated expression profiles, with the highest expression levels at 12 h
-
HMGCS1 expression is downregulated in dorsal root ganglia after spinal nerve injury
induced by methyl jasmonate. The transcript level increases gradually and reaches maximum (5.6fold higher than the control) at 24 h after methyl jasmonate treatment. Thereafter, the transcript level declines but is still significant higher than those of control from 48 to 96 h posttreatment of methyl jasmonate. At 96 h, a 2.4fold increase in expression compared to control is observed
lower renal expression of HMGCS2 in SHRSPs than in SHRs or clofibrate-treated SHRSPs
rubber yields and/or yield characteristics are significantly negatively correlated with enzyme expression levels
the enzyme activity is higher in alcohol-fed rats, but the relative increase in enzyme activity in alcohol-fed rats is less than the relative increase in enzyme expression
the expression level is highest 4 h after induction with methyl jasmonate
transcription is upregulated in response to cold, dark, methyl jasmonate, salicylic acid, and abscisic acid treatments
under the drought stress conditions simulated by 20% PEG, GhHMGS1A expression is slightly down-regulated at 12 h. When seedlings are exposed to 4°C for up to 12 h, GhHMGS1A expression is down-regulated. When seedlings are exposed to 4°C for up to 12 h, GhHMGS1A expression is down-regulated, while GhHMGS1D expression is down-regulated during the first 6 h but is slightly up-regulated at 12 h. GhHMGS2A expression is down-regulated under the cold treatment. The cold stress treatment decreases the GhHMGS3A expression level during the first 6 h but increases it at 12 h
-