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2.3.3.10: hydroxymethylglutaryl-CoA synthase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA synthase, go to the full flat file.

Word Map on EC 2.3.3.10

Reaction

acetyl-CoA
+
H2O
 +
acetoacetyl-CoA
=
(S)-3-hydroxy-3-methylglutaryl-CoA
 +
CoA

Synonyms

(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase I, 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-CoA synthase 1, 3-hydroxy-3-methylglutaryl-CoA synthase 2, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl_coenzyme A synthase, 3-hydroxyl-3-methyl-glutaryl-CoA synthase, acetoacetyl coenzyme A transacetase, beta-hydroxy-beta-methylglutaryl-CoA synthase, BjHMGS1, BjHMGS2, BjHMGS3, BjHMGS4, EC 4.1.3.5, GbHMGS2, GhHMGS1A, GhHMGS1D, GhHMGS2D, GhHMGS3A, GhHMGS3D, HGMS, HMG-CoA, HMG-CoA synthase, HMG-CoA synthase 1, HMG-CoS synthase, HMGCS, HMGCS1, HMGCS2, HMGS, HMGS-2, HMGS1, HMGS2, hydroxy-methylglutaryl coenzyme-A synthase, hydroxymethylglutaryl CoA synthase 2, hydroxymethylglutaryl CoA synthetase, hydroxymethylglutaryl coenzyme A synthase, hydroxymethylglutaryl coenzyme A-condensing enzyme, hydroxymethylglutaryl-CoA synthase, hydroxymethylglutaryl-coenzyme A synthase, LcHMGS, mvaS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.10 hydroxymethylglutaryl-CoA synthase

Inhibitors

Inhibitors on EC 2.3.3.10 - hydroxymethylglutaryl-CoA synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid
-
i.e. F-244
(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecadienenoic acid
(S)-3-hydroxy-3-methylglutaryl-CoA
-
-
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
2-benzyl-9-(3,6-dioxocyclohexa-1,4-dienyl)-2,3,7,8-tetrahydro-6H-pyrido[1,2-a]pyrazine-1,4-dione
-
-
3,3-dimethylglutaryl-CoA
-
-
3-carboxy-2,2,5,5,-tetramethyl-1-pyrrolidinyloxyl-CoA
3-carboxypropionyl-CoA
-
-
3-chloropropionyl-CoA
3-hydroxy-3-methylglutaryl-CoA
-
-
3-oxohexanoyl-CoA
-
-
5,5'-dithiobis(2-nitrobenzoate)
acetoacetyl-CoA
acetyloxy(phenyl)mercury
-
phenyl mercuric acetate
arsenite
-
in presence of CoA, residual activity 25%
bromoacetyl-CoA
-
-
CdSO4
-
residual activity 9%
decanoyl-CoA
-
-
diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
-
disulfiram
DL-3-hydroxy-3-methylglutaryl-CoA
DL-3-methylglutaryl-CoA
-
-
glutaryl-CoA
-
-
heptanoyl-CoA
-
-
hexanoyl-CoA
-
-
hymeglusin
iodoacetamide
L-659,699
Lifibrol
Mg2+
-
mitochondrial enzyme
MgCl2
N-ethylmaleimide
NaAsO2
-
residual activity 90%
nonanoyl-CoA
-
-
octanoyl-CoA
-
-
p-chloromercuribenzoate
palmitoyl-CoA
-
mitochondrial synthase
phenyl arsenious oxide
-
in presence of CoA, residual activity 41%; residual activity 75%
propionyl-CoA
-
-
succinyl-CoA
additional information
-