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2.3.3.10: hydroxymethylglutaryl-CoA synthase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA synthase, go to the full flat file.

Word Map on EC 2.3.3.10

Reaction

acetyl-CoA
+
H2O
+
acetoacetyl-CoA
=
(S)-3-hydroxy-3-methylglutaryl-CoA
+
CoA

Synonyms

(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase I, 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-CoA synthase 1, 3-hydroxy-3-methylglutaryl-CoA synthase 2, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl_coenzyme A synthase, 3-hydroxyl-3-methyl-glutaryl-CoA synthase, acetoacetyl coenzyme A transacetase, beta-hydroxy-beta-methylglutaryl-CoA synthase, BjHMGS1, BjHMGS2, BjHMGS3, BjHMGS4, EC 4.1.3.5, GbHMGS2, GhHMGS1A, GhHMGS1D, GhHMGS2D, GhHMGS3A, GhHMGS3D, HGMS, HMG-CoA, HMG-CoA synthase, HMG-CoA synthase 1, HMG-CoS synthase, HMGCS, HMGCS1, HMGCS2, HMGS, HMGS-2, HMGS1, HMGS2, hydroxy-methylglutaryl coenzyme-A synthase, hydroxymethylglutaryl CoA synthase 2, hydroxymethylglutaryl CoA synthetase, hydroxymethylglutaryl coenzyme A synthase, hydroxymethylglutaryl coenzyme A-condensing enzyme, hydroxymethylglutaryl-CoA synthase, hydroxymethylglutaryl-coenzyme A synthase, LcHMGS, mvaS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.10 hydroxymethylglutaryl-CoA synthase

Source Tissue

Source Tissue on EC 2.3.3.10 - hydroxymethylglutaryl-CoA synthase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
strongly expressed in latex and bark
Manually annotated by BRENDA team
-
enzyme is a direct target of c-Myc, which represses hydroxymethylglutaryl-CoA synthase transcriptional activity
Manually annotated by BRENDA team
satellite glial cells in dorsal root ganglia. HMGCS1 but not HMGCS2 immunoreactivity in satellite glial cells is reduced in the fifth lumbar (L5) dorsal root ganglion that contain axotomized neurons following L5 spinal nerve ligation in rats. HMGCS1 protein level in axotomized L5 dorsal root ganglia is reduced after spinal nerve ligation to 66% at 3 days and 58% at 28 days of its level in control samples, whereas HMGCS2 protein is comparable between injured and control dorsal root ganglia
Manually annotated by BRENDA team
-
of adults
Manually annotated by BRENDA team
-
HMGS2 is well expressed
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
although HMGCS1 expression does not correlate with BRAFV600E mutation in human melanoma cells, HMGCS1 is selectively important for proliferation of BRAFV600E-positive melanoma and colon cancer cells but not control cells harboring activeN/KRAS mutants, and stable knockdown of HMGCS1 only attenuated colony formation and tumor growth potential of BRAFV600E melanoma cells
Manually annotated by BRENDA team
anterior midgut, topically applied juvenile hormone III induced enzyme mRNA levels up to 6.5fold
Manually annotated by BRENDA team
-
GhHMGS1A is moderately expressed at 10 and 40 days post anthesis. GhHMGS1D is moderately expressed at 40 days post anthesis. GhHMGS3A is relatively highly expressed at 20 days post anthesis
Manually annotated by BRENDA team
-
HMGS2 is well expressed
Manually annotated by BRENDA team
-
GhHMGS1A is moderately expressed at 10 and 40 days post anthesis. GhHMGS1D is moderately expressed at 40 days post anthesis. Although the GhHMGS2D expression level is generally low in the examined tissues, GhHMGS2D expression is relatively high in the ovules at 10 and 20 days post anthesis. GhHMGS3A is relatively highly expressed at 20 days post anthesis. GhHMGS3D is significantly expressed at 0 and 30 days post anthesis
Manually annotated by BRENDA team
-
developmental regulation
Manually annotated by BRENDA team
additional information