disruption of OsIPMS1 results in low seed vigour under various conditions, which might be tightly associated with the reduction of amino acids in germinating seeds. Eleven amino acids that associated with stress tolerance, GA biosynthesis and tricarboxylic acid cycle are significantly reduced in osipms1 mutants compared with those in wide type during seed germination. Transcriptome analysis indicates that a total of 1209 differentially expressed genes are altered in osipms1a mutant compared with wilde type at the early germination stage, wherein most of the genes were involved in glycolysis/gluconeogenesis, protein processing, pyruvate, carbon, fructose and mannose metabolism
mutations in the Arabidopsis ROL17/isopropylmalate synthase 1 locus alter amino acid content, modify the TOR network, and suppress the root hair cell development mutant lrx1
an in vivo regulatory model of branched-chain amino acid homeostasis is presented which is derived from analysis of feedback-resistant Arabidopsis thaliana mutants for the three allosteric committed enzymes in the biosynthetic network: threonine deaminase, acetohydroxyacid synthase small subunit 2, and isopropylmalate synthase 1
the enzyme catalyses the committed step of leucine biosynthesis. The regulation of OsIPMS1 in seed vigour is involved in starch hydrolysis, glycolytic activity and energy levels in germinating seeds. The effects of seed priming are tightly associated with the mRNA levels of OsIPMS1 in priming seeds
the enzyme is involved in the leucine biosynthesis pathway and is extremely critical for the synthesis of branched-chain amino acids leucine, isoleucine and valine
the enzyme is involved in the leucine biosynthesis pathway and is extremely critical for the synthesis of branched-chain amino acids leucine, isoleucine and valine
the enzyme is required for the proliferation of Mycobacterium tuberculosis and is also indispensable for its survival during the latent phase of infection
the enzyme is required for the proliferation of Mycobacterium tuberculosis and is also indispensable for its survival during the latent phase of infection