2.3.3.13: 2-isopropylmalate synthase

This is an abbreviated version!
For detailed information about 2-isopropylmalate synthase, go to the full flat file.

Reaction

Synonyms

2-isopropylmalate synthase 1, chloroplastic, 2-isopropylmalate synthase 2, chloroplastic, 3-hydroxy-4-methyl-3-carboxy-pentanoate 2-oxo-3-methyl-butanoate lyase (CoA-acetylating), 3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methyl-butyrate lyase (CoA-acetylating), alpha-IPM synthase, Alpha-IPM synthetase, alpha-IPMS, alpha-IPMS-14CR, alpha-IPMS-2CR, Alpha-isopropylmalate synthase, alpha-isopropylmalate synthase I, alpha-isopropylmalate synthase II, alpha-isopropylmalate synthetase, alpha-isopropylmalic synthetase, BatIMS, EC 4.1.3.12, IPM synthase, IPM-synthase, IPMS, IPMS1, IPMS2, IPMS3, isopropylmalate synthase, isopropylmalate synthase 1, isopropylmalate synthetase, LEU4, LEU9, leuA, Mj1195, MtalphaIPMS, MtIPMS, NmeIPMS, Os11g04670, Os12g04440, OsIPMS1, OsIPMS2, ROL17, synthase, 2-isopropylmalate, synthase, alpha-isopropylmalate, TT_C0849

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.3 Acyl groups converted into alkyl groups on transfer

                2.3.3.13 2-isopropylmalate synthase

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Results	in table
1	Activating Compound
38019	AA Sequence
11	Application
1	CAS Registry Number
24	Cloned(Commentary)
3	Cofactor
5	Crystallization (Commentary)
3	Expression
15	General Information
1	General Stability
1	IC50 Value
112	Inhibitors
15	kcat/KM [mM/s]
46	Ki Value [mM]
116	KM Value [mM]
12	Localization
46	Metals/Ions
31	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
589	Organism
8	Pathway
22	PDB ID
25	pH Optimum
3	pH Range
8	pH Stability
1	Posttranslational Modification
50	Protein Variants
27	Purification (Commentary)
2	Reaction
9	Reaction Type
116	Reference
1	Renatured (Commentary)
20	Source Tissue
15	Specific Activity [micromol/min/mg]
8	Storage Stability
224	Substrates and Products (Substrate)
23	Subunits
116	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Range [°C]
11	Temperature Stability [°C]
75	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 2.3.3.13 - 2-isopropylmalate synthase

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-18°C, 50 mM potassium phosphate, pH 7.2, loss of activity after 3 months

Clostridium pasteurianum

-

636512

-20°C, concentrated protein stored in 20% glycerol

Methanocaldococcus jannaschii

Q58595

727047

-20°C, phosphate leucine buffer, little loss of activity

Neurospora crassa

-

636525

0°C, more than 80% loss of activity after 2 d

Clostridium pasteurianum

-

636512

22°C, in presence of 0.05% sodium azide, 8% loss of activity after 3 months

Clostridium pasteurianum

-

636512

30°C, pH 7.5, stable for more than 10 days

Cupriavidus necator

-

636516

freezing at -20°C and thawing, about 10% loss of activity. Storage at -20°C, 100 mM potassium phosphate, 0.2 mM 2-oxo-3-methylbutanoate, pH 7.5 or pH 8.0, no further loss of activity after 5 months

Cupriavidus necator

-

636516

in an icebox, pH 7.5-8.5, 30% loss of activity after 48 h

Mycobacterium tuberculosis

-

636535