2.3.3.13: 2-isopropylmalate synthase
This is an abbreviated version!
For detailed information about 2-isopropylmalate synthase, go to the full flat file.
Word Map on EC 2.3.3.13
-
2.3.3.13
-
l-leucine
-
4.1.3.12
-
alpha-ketoisovalerate
-
homocitrate
-
beta-isopropylmalate
-
citramalate
-
methylthioalkylmalate
-
alpha-ketobutyrate
-
alpha-ketoisocaproate
-
feedback-resistant
-
acetohydroxyacid
-
acetohydroxy
-
accoa
-
medicine
-
agriculture
-
drug development
-
food industry
- 2.3.3.13
- l-leucine
-
4.1.3.12
- alpha-ketoisovalerate
- homocitrate
- beta-isopropylmalate
- citramalate
-
methylthioalkylmalate
- alpha-ketobutyrate
- alpha-ketoisocaproate
-
feedback-resistant
-
acetohydroxyacid
-
acetohydroxy
- accoa
- medicine
- agriculture
- drug development
- food industry
Reaction
Synonyms
2-isopropylmalate synthase 1, chloroplastic, 2-isopropylmalate synthase 2, chloroplastic, 3-hydroxy-4-methyl-3-carboxy-pentanoate 2-oxo-3-methyl-butanoate lyase (CoA-acetylating), 3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methyl-butyrate lyase (CoA-acetylating), alpha-IPM synthase, Alpha-IPM synthetase, alpha-IPMS, alpha-IPMS-14CR, alpha-IPMS-2CR, Alpha-isopropylmalate synthase, alpha-isopropylmalate synthase I, alpha-isopropylmalate synthase II, alpha-isopropylmalate synthetase, alpha-isopropylmalic synthetase, BatIMS, EC 4.1.3.12, IPM synthase, IPM-synthase, IPMS, IPMS1, IPMS2, IPMS3, isopropylmalate synthase, isopropylmalate synthase 1, isopropylmalate synthetase, LEU4, LEU9, leuA, Mj1195, MtalphaIPMS, MtIPMS, NmeIPMS, Os11g04670, Os12g04440, OsIPMS1, OsIPMS2, ROL17, synthase, 2-isopropylmalate, synthase, alpha-isopropylmalate, TT_C0849
ECTree
2.3.3.13 2-isopropylmalate synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.3.13 - 2-isopropylmalate synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-oxo-3-methylbutanoate + butanoyl-CoA + H2O
3-ethyl-2-hydroxy-2-isopropylsuccinic acid + CoA
-
-
-
-
?
2-oxo-3-methylbutanoate + malonyl-CoA + H2O
2-hydroxy-3-metylbutane-11,2-tricarboxyl acid + CoA
-
-
-
-
?
2-oxo-3-methylbutanoate + propanoyl-CoA + H2O
2-hydroxy-2-isopropyl-3-methylsuccinic acid + CoA
2-oxo-3-methylbutanoate + valeryl-CoA + H2O
2-hydroxy-2-isopropyl-3-propylsuccinic acid + CoA
-
-
-
-
?
2-oxo-3-methylbutanoyl-methylester + H2O
3-hydroxy-3-(methoxycarbonyl)-4-methylpentanoic acid + CoA
-
-
-
-
?
4-methylthio-2-oxopentanoate + acetyl-CoA + H2O
? + CoA
-
at very low rate, reaction is involved in glucosinolate chain elongation
-
?
alpha-ketoisovalerate + acetyl-CoA + H2O
alpha-isopropylmalate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
Alcaligenes viscolactis
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
Bacillus sp. (in: Bacteria) No. 221
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
Chromatium sp.
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
Escherichia coli B / ATCC 11303
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
Hydrogenomonas sp.
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
Hydrogenomonas sp.
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
ir
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
the enzyme catalyzes a Claisen-condensation between acetyl-CoA and 2-oxo-3-methylbutanoate (alpha-ketoisovalerate) followed by hydrolysis to form 3-hydroxy-4-methyl-3-carboxypentanoate (alpha-isopropylmalate) and CoA
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
ir
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
ir
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
i.e. alpha-isopropylmalate
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
Alcaligenes viscolactis
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
involved in Leu biosynthesis
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
Chromatium sp.
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
involved in Leu biosynthesis
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
key enzyme in biosynthesis of Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
the enzyme is regulated by the level of Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
involved in Leu biosynthesis
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
the enzyme is regulated by the level of Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
involved in Leu biosynthesis
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
Escherichia coli B / ATCC 11303
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
Hydrogenomonas sp.
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
repression by Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
repression by Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
involved in Leu biosynthesis
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
involved in Leu biosynthesis
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
involved in Leu biosynthesis
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
the cytoplasmic form is involved in Leu biosynthesis
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
?
-
first enzyme in biosynthesis of L-Leu
-
-
?
2-oxo-3-methylbutanoate + propanoyl-CoA + H2O
2-hydroxy-2-isopropyl-3-methylsuccinic acid + CoA
-
-
-
-
?
2-oxo-3-methylbutanoate + propanoyl-CoA + H2O
2-hydroxy-2-isopropyl-3-methylsuccinic acid + CoA
-
-
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
isoform IPMS1, 112% of the rate with 2-oxo-3-methylbutanoate, isoform IPMS2, 97.5% of the rate with 2-oxo-3-methylbutanoate
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
112.2% of the activity with 2-oxo-3-methylbutanoate
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
97.5% of the activity with 2-oxo-3-methylbutanoate
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
-
-
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
-
-
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
-
-
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
-
-
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
-
-
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
-
-
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
-
-
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
-
-
-
-
?
2-oxo-butanoate + acetyl-CoA + H2O
2-ethyl-2-hydroxysuccinic acid + CoA
-
-
-
-
?
2-oxo-n-pentanoate + acetyl-CoA + H2O
2-hydroxy-2-propylsuccinic acid + CoA
isoform IPMS1, 27.2% of the rate with 2-oxo-3-methylbutanoate, isoform IPMS2, 33.8% of the rate with 2-oxo-3-methylbutanoate
-
-
?
2-oxo-n-pentanoate + acetyl-CoA + H2O
2-hydroxy-2-propylsuccinic acid + CoA
-
-
-
-
?
2-oxo-n-pentanoate + acetyl-CoA + H2O
2-hydroxy-2-propylsuccinic acid + CoA
-
-
-
-
?
2-oxo-n-pentanoate + acetyl-CoA + H2O
2-hydroxy-2-propylsuccinic acid + CoA
-
-
-
-
?
2-oxovalerate + acetyl-CoA + H2O
?
27.2% of the activity with 2-oxo-3-methylbutanoate
-
-
?
2-oxovalerate + acetyl-CoA + H2O
?
33.8% of the activity with 2-oxo-3-methylbutanoate
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
the hydrolytic step is rate-determining
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
the hydrolytic step is rate-determining
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
the enzyme catalyses the committed step of leucine biosynthesis
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
-
-
-
?
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O
(2S)-2-isopropylmalate + CoA
enzyme of the branched-chain amino acid biosynthetic gene cluster. The enzyme is involved in biosynthesis of leucine and isoleucine
-
-
?
acetyl-CoA + alpha-ketoisovalerate + H2O
alpha-isopropylmalate + CoA
-
first step of leucine biosynthesis
-
-
?
acetyl-CoA + alpha-ketoisovalerate + H2O
alpha-isopropylmalate + CoA
-
aldol condensation reaction
-
-
?
acetyl-CoA + alpha-ketoisovalerate + H2O
alpha-isopropylmalate + CoA
-
reaction
-
-
?
acetyl-CoA + alpha-ketoisovalerate + H2O
alpha-isopropylmalate + CoA
-
first step of leucine biosynthesis
-
-
?
acetyl-CoA + alpha-ketoisovalerate + H2O
alpha-isopropylmalate + CoA
-
reaction
-
-
?
alpha-ketoisovalerate + H2O + acetyl-CoA
? + CoA
-
-
-
?
alpha-ketoisovaleric acid + H2O + acetyl-CoA
? + CoA
-
-
-
?
alpha-ketoisovaleric acid + H2O + acetyl-CoA
? + CoA
-
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
isoform IPMS1, 12.7% of the rate with 2-oxo-3-methylbutanoate, isoform IPMS2, 15.7% of the rate with 2-oxo-3-methylbutanoate
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
12.7% of the activity with 2-oxo-3-methylbutanoate
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
15.7% of the activity with 2-oxo-3-methylbutanoate
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
-
-
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
-
-
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
-
-
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
-
-
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
-
-
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
-
-
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
-
-
-
-
?
pyruvate + acetyl-CoA + H2O
2-hydroxy-2-methylsuccinic acid + CoA
-
-
-
-
?
additional information
?
-
isoform IPMS2 shows no activity with 4-methylthio-2-oxobutyrate or 2-oxohexanoate
-
-
?
additional information
?
-
no activity with (3RS)-3-methyl-2-oxovalerate and 4-methyl-2-oxovalerate
-
-
?
additional information
?
-
isoform IPMS3 shows no activity with 4-methylthio-2-oxobutyrate or 2-oxoisovalerate
-
-
?
additional information
?
-
-
isoform IPMS3 shows no activity with 4-methylthio-2-oxobutyrate or 2-oxoisovalerate
-
-
?
