2.3.3.13: 2-isopropylmalate synthase

This is an abbreviated version!
For detailed information about 2-isopropylmalate synthase, go to the full flat file.

Word Map on EC 2.3.3.13

2.3.3.13

l-leucine

4.1.3.12

alpha-ketoisovalerate

homocitrate

beta-isopropylmalate

citramalate

methylthioalkylmalate

alpha-ketobutyrate

alpha-ketoisocaproate

feedback-resistant

acetohydroxyacid

acetohydroxy

accoa

medicine

agriculture

drug development

food industry

Reaction

Synonyms

2-isopropylmalate synthase 1, chloroplastic, 2-isopropylmalate synthase 2, chloroplastic, 3-hydroxy-4-methyl-3-carboxy-pentanoate 2-oxo-3-methyl-butanoate lyase (CoA-acetylating), 3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methyl-butyrate lyase (CoA-acetylating), alpha-IPM synthase, Alpha-IPM synthetase, alpha-IPMS, alpha-IPMS-14CR, alpha-IPMS-2CR, Alpha-isopropylmalate synthase, alpha-isopropylmalate synthase I, alpha-isopropylmalate synthase II, alpha-isopropylmalate synthetase, alpha-isopropylmalic synthetase, BatIMS, EC 4.1.3.12, IPM synthase, IPM-synthase, IPMS, IPMS1, IPMS2, IPMS3, isopropylmalate synthase, isopropylmalate synthase 1, isopropylmalate synthetase, LEU4, LEU9, leuA, Mj1195, MtalphaIPMS, MtIPMS, NmeIPMS, Os11g04670, Os12g04440, OsIPMS1, OsIPMS2, ROL17, synthase, 2-isopropylmalate, synthase, alpha-isopropylmalate, TT_C0849

ECTree

2 Transferases

2.3 Acyltransferases

2.3.3 Acyl groups converted into alkyl groups on transfer

2.3.3.13 2-isopropylmalate synthase

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Results	in table
1	Activating Compound
38019	AA Sequence
11	Application
1	CAS Registry Number
24	Cloned(Commentary)
3	Cofactor
5	Crystallization (Commentary)
3	Expression
15	General Information
1	General Stability
1	IC50 Value
112	Inhibitors
15	kcat/KM [mM/s]
46	Ki Value [mM]
116	KM Value [mM]
12	Localization
46	Metals/Ions
31	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
589	Organism
8	Pathway
22	PDB ID
25	pH Optimum
3	pH Range
8	pH Stability
1	Posttranslational Modification
50	Protein Variants
27	Purification (Commentary)
2	Reaction
9	Reaction Type
116	Reference
1	Renatured (Commentary)
20	Source Tissue
15	Specific Activity [micromol/min/mg]
8	Storage Stability
224	Substrates and Products (Substrate)
23	Subunits
116	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Range [°C]
11	Temperature Stability [°C]
75	Turnover Number [1/s]

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0.77 - 13

2-oxo-3-methylbutanoate

12 entries

10.7

2-oxo-butanoate

Mycobacterium tuberculosis

pH 7.4, 25°C

672203

2-oxo-n-pentanoate

Mycobacterium tuberculosis

pH 7.4, 25°C

672203

0.49 - 1.08

2-oxoisovalerate

2 entries

105

3-Fluoropyruvate

Neisseria meningitidis

Q9JZG1

pH 7.5, 25°C

702097

1.2 - 450

3-methyl-2-oxobutanoate

11 entries

0.28

3-methyl-2-oxopentanoate

Neisseria meningitidis

Q9JZG1

pH 7.5, 25°C

702097

0.12

4-methylthio-2-oxobutyrate

Solanum lycopersicum

K4C627, K4CJ56

isoform IPMS3, pH and temperature not specified in the publication

737033

0.03 - 450

acetyl-CoA

29 entries

1.36

alpha-Ketobutyrate

Neisseria meningitidis

Q9JZG1

pH 7.5, 25°C

702097

0.022 - 4.75

alpha-ketoisovalerate

8 entries

0.52 - 1.17

alpha-ketoisovaleric acid

2 entries

0.04 - 0.05

crotonyl-CoA

2 entries

0.04

propionyl-CoA

Mycobacterium tuberculosis

hydrolysis, absence of MgCl2, pH 7.4, 25°C

672203

1.5 - 6.1

pyruvate

2 entries