Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.3.3.14: homocitrate synthase

This is an abbreviated version!
For detailed information about homocitrate synthase, go to the full flat file.

Word Map on EC 2.3.3.14

Reaction

acetyl-CoA
+
H2O
+
2-oxoglutarate
=
(2R)-2-hydroxybutane-1,2,4-tricarboxylate
+
CoA

Synonyms

2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), acetyl-coenzyme A: 2-ketoglutarate C-transferase, acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase, EC 4.1.3.21, HCS, HcsA, homocitrate synthase, homocitrate synthetase, homocitrate-condensing enzyme, homocondensing enzyme, LYS20, LYS21, Lys21p, LYS22, Lys22p, nifV, nifV2, saci_1304, SpHCS, synthase, homocitrate, TtHCS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.14 homocitrate synthase

Crystallization

Crystallization on EC 2.3.3.14 - homocitrate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
the crystal structure of the homocitrate synthase apoenzyme and two distinct structures of the enzyme in complex with the substrate 2-oxoglutarate are reported
-
the structure of SpHCS in complex with the inhibitor L-lysine and Zn2+ is solved at a resolution of 2.38 A
the crystal structures of homocitrate synthase complexed with 2-oxoglutarate, (R)-2-hydroxybutane-1,2,4-tricarboxylate, or lysine are determined
-