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2.3.3.14: homocitrate synthase

This is an abbreviated version!
For detailed information about homocitrate synthase, go to the full flat file.

Word Map on EC 2.3.3.14

Reaction

acetyl-CoA
+
H2O
 +
2-oxoglutarate
=
(2R)-2-hydroxybutane-1,2,4-tricarboxylate
 +
CoA

Synonyms

2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), acetyl-coenzyme A: 2-ketoglutarate C-transferase, acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase, EC 4.1.3.21, HCS, HcsA, homocitrate synthase, homocitrate synthetase, homocitrate-condensing enzyme, homocondensing enzyme, LYS20, LYS21, Lys21p, LYS22, Lys22p, nifV, nifV2, saci_1304, SpHCS, synthase, homocitrate, TtHCS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.14 homocitrate synthase

KI Value

KI Value on EC 2.3.3.14 - homocitrate synthase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
26
2-oxoglutarate
-
pH 7.2
10
2-Oxomalonate
-
pH 7.2
13.5 - 200
citrate
0.008 - 0.11
CoA
0.014 - 0.18
desulfo-CoA
5.1
DL-alpha-aminoadipate
-
-
26
Glutarate
-
pH 7.2
0.4
glyoxylate
-
pH 7.2
0.008 - 0.0094
L-Lys
5
L-lysine
-
-
0.94 - 15
L-thialysine
0.053 - 2
lysine
1
oxalate
-
pH 7.2
0.9
oxalglycine
-
in 50 mM HEPES, pH 7.5, at 25°C
4
oxaloacetate
-
pH 7.2
7.7
oxalylglycine
-
pH 7.2
3
pyridine-2,3-dicarboxylate
-
pH 7.2
0.6
Pyridine-2,4-dicarboxylate
-
pH 7.2
14
Pyridine-2,5-dicarboxylate
-
pH 7.2
0.7
pyridine-2,6-dicarboxylate
-
pH 7.2
0.43
pyridine-2-carboxylate
-
pH 7.2
0.14 - 1.1
Selenalysine
46
succinyl phosphonate
-
pH 7.2
additional information
additional information
-
-
-