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2.3.3.16: citrate synthase (unknown stereospecificity)

This is an abbreviated version!
For detailed information about citrate synthase (unknown stereospecificity), go to the full flat file.

Word Map on EC 2.3.3.16

Reaction

acetyl-CoA
+
H2O
+
oxaloacetate
=
citrate
+
CoA

Synonyms

bifunctional citrate synthase/2-methylcitrate synthase, CCNA_01983, CIT1, CitA, citrate condensing enzyme, citrate oxaloacetate-lyase (CoA-acetylating), citrate oxaloacetate-lyase, CoA-acetylating, citrate synthase, citrate synthase Cit1, citrate synthase/2-methylcitrate synthase, citrate synthetase, citric synthase, citric-condensing enzyme, citrogenase, CitZ, CS, CS1, CS2, CS3, CS4, CSI, CSY, CSY4, CTS, EC 4.1.3.7, gltA, GltA2, MCS, mitochondrial citrate synthase, mmgD, More, Msed_1522, oxalacetic transacetase, oxaloacetate transacetase, peroxisomal citrate synthase, Rv0896, SbnG, Si-citrate synthase, sll0401, SSO2589, St0589, St1805, synthase, citrate, TTHA1343, type II citrate synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.16 citrate synthase (unknown stereospecificity)

General Stability

General Stability on EC 2.3.3.16 - citrate synthase (unknown stereospecificity)

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
CS II much more stable than CS I
-
destabilization by all salts, exception is ammonium sulfate, which stabilizes at low concentration
-
dilute solutions instable, best stabilized by high concentrations of NaCl or KCl
-
dithiothreitol stabilizes for about 5 days
-
freeze-drying results in 70% loss of activity
-
KCl stabilizes
-
peroxisomal enzyme protected by oxaloacetate
-
very instable without glycerol
-
very labile, 97% loss of activity after 2 d at 0°C due to aggregation
-
very labile, glycerol, 20% v/v or more stabilizes
-