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2.3.3.3: citrate (Re)-synthase

This is an abbreviated version!
For detailed information about citrate (Re)-synthase, go to the full flat file.

Word Map on EC 2.3.3.3

Reaction

acetyl-CoA
+
H2O
+
oxaloacetate
=
citrate
+
CoA

Synonyms

(R)-citrate synthase, cbdbA1708, citrate oxaloacetate-lyase [(pro-3-R)-CH2COO-acetyl-CoA], CLO1313_RS03665, EC 4.1.3.28, Re-citrate synthase, Re-citrate-synthase, Re-CS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.3 citrate (Re)-synthase

Inhibitors

Inhibitors on EC 2.3.3.3 - citrate (Re)-synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxoglutarate
4-chloromercuribenzoate
4-hydroxymercuribenzoate
-
complete inhibition at 0.1 mM
5,5'-dithiobis-2-nitrobenzoate
-
30% inhibition at 10 mM
aerobic conditions
-
50% inactivation in 24 h by aerobic conditions
-
Cd2+
Clostridium acidi-urici
-
complete inactivation
citrate
H2O2
Clostridium acidi-urici
-
-
Hg2+
Clostridium acidi-urici
-
complete inactivation
iodoacetamide
Clostridium acidi-urici
-
strong inhibition
L-lysine
about 80% residual activity at 0.5 mM
p-chloromercuribenzoate
-
0.002 mM, inactivation
Zn2+
Clostridium acidi-urici
-
above 0.02 mM, activation below
additional information
-