2.3.3.5: 2-methylcitrate synthase

This is an abbreviated version!
For detailed information about 2-methylcitrate synthase, go to the full flat file.

Word Map on EC 2.3.3.5

2.3.3.5

propionate

propionyl-coa

dehydratase

acetyl-coa

3-hydroxyvalerate

mcsa

methylisocitrate

polyhydroxyalkanoates

methylmalonyl-coa

propionyl

eutropha

halomonas

paracoccidioidomycosis

odd-chain

drug development

lutzii

paracoccidioides

coa-transferase

prpbcde

butyryl-coa

medicine

agriculture

Reaction

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate

Synonyms

2-MC synthase, 2-MCS, 2-MCS1, 2-methylcitrate oxaloacetate-lyase, 2-methylcitrate synthase 2, citrate synthase II, citrate synthase/2-methylcitrate synthase, EC 4.1.3.31, MCA condensing enzyme, MCS, Mcs1, mcsA, Methylcitrate synthase, methylcitrate synthetase, mmgD, MscA, PrpC, prpC2, Rv1131

ECTree

2 Transferases

2.3 Acyltransferases

2.3.3 Acyl groups converted into alkyl groups on transfer

2.3.3.5 2-methylcitrate synthase

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Results	in table
1	Activating Compound
271	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
4	Cofactor
1	Crystallization (Commentary)
3	Expression
14	General Information
22	Inhibitors
8	kcat/KM [mM/s]
15	Ki Value [mM]
43	KM Value [mM]
10	Localization
4	Metals/Ions
17	Molecular Weight [Da]
137	Natural Substrates/ Products (Substrates)
501	Organism
6	Pathway
42	PDB ID
6	pH Optimum
4	pH Range
1	pH Stability
4	pI Value
1	Posttranslational Modification
5	Protein Variants
17	Purification (Commentary)
2	Reaction
5	Reaction Type
131	Reference
2	Source Tissue
65	Specific Activity [micromol/min/mg]
213	Substrates and Products (Substrate)
13	Subunits
45	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
5	Temperature Range [°C]
5	Temperature Stability [°C]
14	Turnover Number [1/s]

General Information

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General Information on EC 2.3.3.5 - 2-methylcitrate synthase

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malfunction

Pyricularia oryzae

deletion of MCS1 (2-methylcitrate synthase) and MCL1 (2-methylisocitrate lyase) inhibits fungal growth on media containing both glucose and propionate, and media using propionate or propionyl-CoA-producing amino acids (valine, isoleucine, methionine, and threonine) as the sole carbon or nitrogen sources. The DELTAmcs1 mutant forms sparse aerial hyphae and does not produce conidia on complete medium, while the DELTAmcl1 mutant shows decreased conidiation. The aerial mycelium of DELTAmcs1 displays lowered NAD+/NADH ratio, reduced nitric oxide content, and down-regulated transcription of hydrophobin genes. DELTAmcl1 shows reduced appressorium turgor, severely delayed plant penetration, and weakened virulence. Addition of acetate recovers the growth of the wild type and DELTAmcs1 on medium containing both glucose and propionate and recovers the conidiation of both DELTAmcs1 and DELTAmcl1 on complete medium by reducing propionyl-CoA formation. Deletion of MCL1 together with ICL1, an isocitrate lyase gene in the glyoxylate cycle, greatly reduces the virulence of the mutant as compared to the single gene deletion mutants (DELTAicl1 and DELTAmcl1)

757708

metabolism

10 entries

physiological function

3 entries