2.3.3.5: 2-methylcitrate synthase

This is an abbreviated version!
For detailed information about 2-methylcitrate synthase, go to the full flat file.

Reaction

Synonyms

2-MC synthase, 2-MCS, 2-MCS1, 2-methylcitrate oxaloacetate-lyase, 2-methylcitrate synthase 2, citrate synthase II, citrate synthase/2-methylcitrate synthase, EC 4.1.3.31, MCA condensing enzyme, MCS, Mcs1, mcsA, Methylcitrate synthase, methylcitrate synthetase, mmgD, MscA, PrpC, prpC2, Rv1131

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.3 Acyl groups converted into alkyl groups on transfer

                2.3.3.5 2-methylcitrate synthase

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Results	in table
1	Activating Compound
271	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
4	Cofactor
1	Crystallization (Commentary)
3	Expression
14	General Information
22	Inhibitors
8	kcat/KM [mM/s]
15	Ki Value [mM]
43	KM Value [mM]
10	Localization
4	Metals/Ions
17	Molecular Weight [Da]
137	Natural Substrates/ Products (Substrates)
501	Organism
6	Pathway
42	PDB ID
6	pH Optimum
4	pH Range
1	pH Stability
4	pI Value
1	Posttranslational Modification
5	Protein Variants
17	Purification (Commentary)
2	Reaction
5	Reaction Type
131	Reference
2	Source Tissue
65	Specific Activity [micromol/min/mg]
213	Substrates and Products (Substrate)
13	Subunits
45	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
5	Temperature Range [°C]
5	Temperature Stability [°C]
14	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.3.5 - 2-methylcitrate synthase

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SYSTEMATIC NAME

IUBMB Comments

propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)

The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1, citrate (Si)-synthase. Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.