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2.3.3.9: malate synthase

This is an abbreviated version!
For detailed information about malate synthase, go to the full flat file.

Word Map on EC 2.3.3.9

Reaction

acetyl-CoA
+
glyoxylate
 +
H2O
=
(S)-malate
 +
CoA

Synonyms

EC 4.1.3.2, GCE, GCE(13-573), glcB, glyoxylate cycle enzyme, glyoxylate transacetase, glyoxylic transacetase, L-malate glyoxylate-lyase (CoA-acetylating), malate synthase, malate synthase 1, malate synthase A, malate synthase G, malate synthase H, malate synthetase, malic synthetase, malic-condensing enzyme, MLS, MSA, MSG, MSH, SSO1334

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.9 malate synthase

Inhibitors

Inhibitors on EC 2.3.3.9 - malate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1S,2S,3R)-2-(5-methoxy-9H-b-carbolin-1-yl)-1-methyl-3-(prop-1-en-2-yl)cyclopentanol
-
-
16-ethenyl-21-oxo-19,20-didehydro-18-oxayohimban-17-yl hexopyranoside
-
-
2,4,5-trioxopyrrolidine-3-carboxamide
-
competitive
3-ethenyl-2-(5-methoxy-9H-b-carbolin-1-yl)-1-methylcyclopentanol
-
-
9-(hydroxymethyl)-8-methyl-8,9,10,11,11a,12-hexahydro-6H-6,10:11,12a-dimethanoindolo[3,2-b]quinolizin-13-yl acetate
-
-
acetaldehyde
-
weak
acetyl-CoA
Bromopyruvate
Butanedione
-
slight inhibition at high concentrations
Ca2+
-
5 mM, 19% residual activity
chloroacetyl-CoA
-
-
citrate
-
1 mM, 82% residual activity
coenzyme A
-
0.1 mM, 56% residual activity
D-fructose-1,6-bisphosphate
-
10 mM, 60% residual activity
deamino-acetyl-CoA
-
-
deoxycholate
-
-
dephosphoacetyl-CoA
-
-
dethio-CoA
uncompetitive inhibitor versus glyoxylate and competitive inhibitor versus acetyl-CoA
diethyl dicarbonate
-
inhibition prevented by preincubation with acetyl-CoA
EDTA
-
1.0 mM, 30% inhibition
fluoroacetate
glycolate
Glyoxal
-
10 mM, 70% residual activity
glyoxylate
iodoacetate
-
5 mM, 6% residual activity
K+
-
5 mM, 5% residual activity
malate
-
1.0 mM, 50% inhibition
methyl 13-amino-2,11-dimethoxy-3-[(3,4,5-trimethoxybenzoyl)oxy]-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindeno[2',1':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
-
-
methylglyoxal
-
-
Mn2+
-
5 mM, 16% residual activity
Na+
-
5 mM, 10% residual activity
oxalate
oxaloacetate
p-chloromercuribenzoate
-
0.05 mM, 9% residual activity
parabanic acid
-
competitive
phosphoenolpyruvate
pyridoxal-5'-phosphate
-
preincubation with glyoxylate but not acetyl-CoA prevents inhibition
pyruvate
S-acetonyl-CoA
-
-
S-ethyl-CoA
-
-
additional information
-