2.3.3.9: malate synthase

This is an abbreviated version!
For detailed information about malate synthase, go to the full flat file.

Reaction

Synonyms

EC 4.1.3.2, GCE, GCE(13-573), glcB, glyoxylate cycle enzyme, glyoxylate transacetase, glyoxylic transacetase, L-malate glyoxylate-lyase (CoA-acetylating), malate synthase, malate synthase 1, malate synthase A, malate synthase G, malate synthase H, malate synthetase, malic synthetase, malic-condensing enzyme, MLS, MSA, MSG, MSH, SSO1334

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.3 Acyl groups converted into alkyl groups on transfer

                2.3.3.9 malate synthase

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Results	in table
2	Activating Compound
26198	AA Sequence
1	Application
1	CAS Registry Number
25	Cloned(Commentary)
6	Crystallization (Commentary)
10	Expression
4	General Information
10	General Stability
7	IC50 Value
99	Inhibitors
43	Ki Value [mM]
71	KM Value [mM]
20	Localization
51	Metals/Ions
78	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
110	Organism
13	Pathway
70	PDB ID
22	pH Optimum
12	pH Range
9	pH Stability
1	pI Value
5	Posttranslational Modification
20	Protein Variants
45	Purification (Commentary)
7	Reaction
3	Reaction Type
105	Reference
1	Renatured (Commentary)
37	Source Tissue
37	Specific Activity [micromol/min/mg]
7	Storage Stability
109	Substrates and Products (Substrate)
61	Subunits
66	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
8	Temperature Range [°C]
18	Temperature Stability [°C]
13	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.3.3.9 - malate synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

acetyl-CoA + H2O + glyoxylate

(S)-malate + CoA

6 entries

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

16 entries

additional information

?

-

5 entries

acetyl-CoA + H2O + glyoxylate

(S)-malate + CoA

Escherichia coli

-

-

735671

-

-

?

acetyl-CoA + H2O + glyoxylate

(S)-malate + CoA

Haloferax volcanii

-

key enzyme of the glyoxylate cycle enzyme

727500

-

-

?

acetyl-CoA + H2O + glyoxylate

(S)-malate + CoA

Haloferax volcanii DSM 3757

-

key enzyme of the glyoxylate cycle enzyme

727500

-

-

?

acetyl-CoA + H2O + glyoxylate

(S)-malate + CoA

Mycobacterium tuberculosis

-

-

735960, 735982

-

-

?

acetyl-CoA + H2O + glyoxylate

(S)-malate + CoA

Paracoccidioides sp.

-

-

735447, 735853, 737048

-

-

?

acetyl-CoA + H2O + glyoxylate

(S)-malate + CoA

Paracoccidioides sp. ATCC MYA-826

-

-

735853

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Bacillus sp. (in: Bacteria)

-

enzyme specifically involved in glyoxalate cycle metabolism

638480

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Colwellia maris

-

enzyme specifically involved in glyoxalate cycle metabolism

638504

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Colwellia maris

-

enzyme essential for acetate use in the bacterial cells

638504

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Cucumis sativus

-

-

638476

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Cucumis sativus

-

enzyme specifically involved in glyoxalate cycle metabolism

638473

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Escherichia coli

-

enzyme specifically involved in glyoxalate cycle metabolism

638480, 638502

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Euglena gracilis

-

enzyme specifically involved in glyoxalate cycle metabolism

638482

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Gossypium hirsutum

-

enzyme specifically involved in glyoxalate cycle metabolism

638471, 638478, 638505

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Helianthus annuus

-

enzyme specifically involved in glyoxalate cycle metabolism

638505

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Ogataea angusta

-

enzyme specifically involved in glyoxalate cycle metabolism

638496

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Petricolaria pholadiformis

-

enzyme specifically involved in glyoxalate cycle metabolism

638501

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Pinus taeda

-

enzyme specifically involved in glyoxalate cycle metabolism

638492

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Ricinus communis

-

enzyme specifically involved in glyoxalate cycle metabolism

638470

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Saccharomyces cerevisiae

-

enzyme specifically involved in glyoxalate cycle metabolism

638503

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Streptomyces arenae

-

enzyme specifically involved in glyoxalate cycle metabolism

638491

-

-

?

glyoxylate + acetyl-CoA + H2O

(S)-malate + CoA

Zea mays

-

enzyme specifically involved in glyoxalate cycle metabolism

638498

-

-

?

additional information

?

-

Candida albicans

-

glyoxylate cycle enzyme

676121

-

-

?

additional information

?

-

Fomitopsis palustris

-

key enzymes of the glyoxylate cycle

670169

-

-

?

additional information

?

-

Oryza sativa

-

characteristic enzymes of the glyoxylate cycle

663463

-

-

?

additional information

?

-

Sinorhizobium meliloti

-

glcB (encoding malate synthase), in the absence of the 240-bp open reading frame SMc00767 is required for acetate metabolism. Malate synthase is not involved in nodulation or nitrogen fixation in the interaction of Sinorhizobium meliloti with alfalfa plants. glcB is dispensable in plant-microbe interactions

680497

-

-

?

additional information

?

-

Sinorhizobium meliloti Rm5000

-

glcB (encoding malate synthase), in the absence of the 240-bp open reading frame SMc00767 is required for acetate metabolism. Malate synthase is not involved in nodulation or nitrogen fixation in the interaction of Sinorhizobium meliloti with alfalfa plants. glcB is dispensable in plant-microbe interactions

680497

-

-

?