2.4.1.101: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-, alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, AtGnTI, beta-1-2 GlcNAc transferase, ChGnTI, EC 2.4.1.51, GlcNAc transferase I, GlcNAc-T I, GlcNAc-TI, GlcNAcT-I, gly-12, GLY-13, gly-14, GnT I, GnT-I, GnT1, GnTI, Golgi N-glycan branching N-acetylglucosaminyltransferase I, HuGnTI, MGAT1, N-acetylglucosaminyltransferase I, N-acetylglucosaminyltransferases I, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, NT, pigGnT-I, PtGnTI, TbGnTI, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase, UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, UDP-GlcNac:alpha3-D-mannoside beta1,2-Nacetylglucosaminyltransferase I, UDP-GlcNAc:alpha3-D-mannoside beta1-2-N-acetylglucosaminyltransferase I, UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-glucosamine to alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2) beta-1,2-N-acetyl-D-glucosaminyltransferase, UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-GlcNAc:alpha3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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Results	in table
9	Activating Compound
2690	AA Sequence
5	Application
1	CAS Registry Number
32	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
3	Expression
36	General Information
4	General Stability
28	Inhibitors
9	Ki Value [mM]
52	KM Value [mM]
45	Localization
82	Metals/Ions
31	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
71	Organism
5	Pathway
7	PDB ID
15	pH Optimum
4	pH Range
1	pH Stability
6	Posttranslational Modification
40	Protein Variants
18	Purification (Commentary)
10	Reaction
1	Reaction Type
68	Reference
47	Source Tissue
15	Specific Activity [micromol/min/mg]
6	Storage Stability
183	Substrates and Products (Substrate)
10	Subunits
112	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]

Application

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Application on EC 2.4.1.101 - alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

biotechnology

3 entries

medicine

Sus scrofa

-

mutant enzyme does not show any activity in an HPLC analysis. In the case of pig cell transfectants with pigGnT-I(320), cell surface carbohydrate structures are significantly altered and its antigenicity to human serum is reduced. pigGnT-I(320) appears to be potentially useful in xenotransplantation by remodeling the carbohydrate structures on pig cells

671754

molecular biology

Homo sapiens

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production of rare hybrid oligosaccharides for biochemical and structural studies, 100% conversion of oligosaccharide substrate at room temperature, yield of 42% after purification from reaction mixture

707016

biotechnology

Homo sapiens

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immobilization of the enzyme as maltose-binding fusion protein on an amylose resin for production of high-mannose type oligosaccharides

488379

biotechnology

Rattus norvegicus

-

production of glycoprotein therapeutics in recombinant Saccharomyces cerevisiae adapted to production of hybrid- and complex-type carbohydrates

488375

biotechnology

Nicotiana tabacum

-

the fusion of the human beta 1,4-galacosyltransferase with the targeting domain of Nicotiana N-acetylglucosaminyltransferase I does not increase the level of beta 1,4-galactosylation in alfalfa, the expression in alfalfa strongly reduces the biosynthesis of Lewis a glycoepitope responsible for plant N-glycan immunogenicity in mammals

694620