Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.4.1.102: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.102

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein]
=
UDP
 +
O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]

Synonyms

2beta-1,6-acetylglucosaminyltransferase, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-, A, bC2GnT-M, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, beta-1,6-N-acetylglucosaminyltransferase, beta1,6-N-acetylglucosaminyltransferase, beta6-N-acetylglucosaminyltransferase, Bo17, C2 beta6GnT1, C2/4GnT, C24GNT, C2GlcNAcT-I, C2GlcNAcT-II, C2GlcNAcT-III, C2GnT, C2GnT-1, C2GnT-I, C2GnT-L, c2GnT-M, C2GnT1, C2GnT2, C2GnT3, C2GNTM, C4GnT, core 2 acetylglucosaminyltransferase, core 2 beta-1, 6-N-acetylglucosaminyltransferase-1, core 2 beta-1,6 N-acetylglucosaminyltransferase, core 2 beta-1,6-N-acetylglucosaminyltransferase, core 2 beta1,6 N-acetylglucosaminyltransferase, core 2 beta1,6 N-acetylglucosaminyltransferase-I, core 2 beta1,6-N-acetyl-glycosaminyltransferase, core 2 beta1,6-N-acetylglucosaminyl transferase 1, core 2 beta1,6-N-acetylglucosaminyltransferase, core 2 beta1,6-N-acetylglucosaminyltransferase I, core 2 beta1,6-N-acetylglucosaminyltransferase-I, core 2 beta6-GlcNAc-transferase, core 2 beta6-N-acetylglucosaminyltransferase, core 2 GlcNAc-T, core 2 N-acetylglucosaminyltransferase, Core 2 N-acetylglucosaminyltransferase 2/M, core 2 N-acetylglucosaminyltransferase M, core 2 N-acetylglucosaminyltransferase-1, core 2 N-acetylglucosaminyltransferase-M, core 2 protein beta-1,6-N-acetylglucosaminyltransferase-mucin type, core 2beta 1,6 N-acetylglucosaminyltransferase, core 2beta-1,6-acetylglucosaminyltransferase, core 6-beta-GlcNAc-T, core 6-beta-GlcNAc-transferase A, core2 1-6-N-glucosaminyltransferase-I, core2 beta(1,6)-N-acetyglucosaminyltransferase-I, core2 beta-1,6-N-acetylglucosaminyltransferase, core2 beta-1,6-N-acetylglucosaminyltransferase-1, Core2beta1,6GnT type M, core2GnT, GCNT1, gcnt3, gcnt4, GnT-III, GNTM, More, mucin-type core 2 1,6-N-acetylglucosaminyltransferase enzyme, mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-acetylglucosaminyltransferase A

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.102 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Inhibitors

Inhibitors on EC 2.4.1.102 - beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12-O-tetradecanoylphorbol-13-acetate
-
about 10fold decreased activity, down-regulation of native enzyme in KM3 leukemia cell line, but not of the recombinant enzyme; i.e. TPA
5,5'-dithiobis-2-nitrobenzoic acid
-
inactivation is partially prevented by prior addition of donor or acceptor substrate and by sulfhydryl reducing agents. 1 mM inhibits 94%
beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
and other nitrophenyl-sugar-derivatives; strong inhibition under UV-radiation at 350 nm, specific for substrate binding site, preincubation with beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl partially protects
Ca2+
-
slight inhibition
diethyldicarbonate
-
0.2 mM, 74% inhibition
EDTA
-
slight inhibition
Hydroxyphenylglyoxal
-
19% inhibition at 0.25 mM, complete inhibition at 5-10 mM
iodoacetate
-
0.2 mM inhibits the enzyme 70%
jacalin
core 1 O-glycan-specific lectin from Artocarpus integrifolia, differing sensitivity of different BoHV-4 mutants to jacalin-mediated neutralization, overview
-
N-bromosuccinimide
-
5 mM, complete inhibition
NEM
-
inactivation is partially prevented by prior addition of donor or acceptor substrate and by sulfhydryl reducing agents. 0.2 mM inhibits 42%
substrate analogues lacking the 6-hydroxyl of the N-acetylgalactosamine
-
weak
-
talniflumate
Triton X-100
-
activation at 0.1% v/v, inhibition at higher concentrations, pig stomach
tunicamycin
-
inactivation; prevents secretion of recombinant enzyme from Sf9 cells
additional information
-