2.4.1.129: peptidoglycan glycosyltransferase
This is an abbreviated version!
For detailed information about peptidoglycan glycosyltransferase, go to the full flat file.
Reaction
+
=
+
Synonyms
bacterial cell wall glycosyltransferase, bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase, bifunctional penicillin-binding protein, class A penicillin-binding protein, class B penicillin-binding protein, DD-transpeptidase, ftsI, glycosyltransferase, peptidoglycan, glycosyltransferase/acyltransferase penicillin-binding protein 4, GTase, MGT, monofunctional glycosyltransferase, mrcB, MtgA, murein synthase, PBP, PBP 1a, PBP 2b, PBP 2x, PBP 3, PBP-1A, PBP-1B, PBP-1C, PBP-2, PBP1, PBP1a, PBP1b, PBP1c, PBP2, PBP2A, PBP2b, PBP2c, PBP2d, PBP3, PBP4, PBP7, PBP8, PBPA, PenA, penicillin binding protein, penicillin binding protein 1b, penicillin-binding protein, penicillin-binding protein 1a, penicillin-binding protein 1B, penicillin-binding protein 2, penicillin-binding protein 3, peptidoglycan glycosyltransferase, peptidoglycan transglycosylase, PG-II, PGT, SgtB, SpoIID
ECTree
IC50 Value
IC50 Value on EC 2.4.1.129 - peptidoglycan glycosyltransferase
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0.0098
(3E,7E,14E)-4,9,9,15,19-pentamethyl-12-methylideneicosa-3,7,14,18-tetraen-1-yl (2R)-3-[[[[(2R,3R,4S,5S,6S)-6-carbamoyl-3-[[(2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-([[3-(trifluoromethyl)phenyl]carbonyl]amino)tetrahydro-2H-pyran-2-yl]oxy]-5-hydroxy-4-([[4-(trifluoromethoxy)-3-(trifluoromethyl)phenyl]carbamoyl]amino)tetrahydro-2H-pyran-2-yl]oxy](hydroxy)phosphoryl]oxy]-2-hydroxypropanoate
Escherichia coli
-
-
0.034
(3Z)-5-(4-bromophenyl)-3-[(5-nitrofuran-2-yl)methylidene]furan-2(3H)-one
Helicobacter pylori
-
-
0.0037
(4Z)-2,5-diphenyl-4-[2-(1,3-thiazol-2-yl)hydrazinylidene]-2,4-dihydro-3H-pyrazol-3-one
Helicobacter pylori
-
-
2.156
(E)-2-(1-(4-(methoxymethyl)phenyl)-2-oxoindolin-3-ylidene)hydrazine-1-carboximidamide
Escherichia coli
pH and temperature not specified in the publication, recombinant enzyme
0.0828
(E)-2-(1-(4-butylphenyl)-2-oxoindolin-3-ylidene)hydrazine-1-carboximidamide
Escherichia coli
pH and temperature not specified in the publication, recombinant enzyme
0.203
(E)-2-(1-(4-ethoxyphenyl)-2-oxoindolin-3-ylidene)hydrazine-1-carboximidamide
Escherichia coli
pH and temperature not specified in the publication, recombinant enzyme
0.125
(E)-2-(1-(4-ethylphenyl)-2-oxoindolin-3-ylidene)hydrazine-1-carboximidamide
Escherichia coli
pH and temperature not specified in the publication, recombinant enzyme
0.0124
(E)-2-(1-(4-octylphenyl)-2-oxoindolin-3-ylidene)hydrazine-1-carboximidamide
Escherichia coli
pH and temperature not specified in the publication, recombinant enzyme
0.0093
4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]benzoic acid
Helicobacter pylori
-
-
0.0497 - 0.0732
4-[3-amino-3-([1,1'-biphenyl]-4-yl)propanamido]-1,5-anhydro-2,4-dideoxy-3-O-[2-deoxy-2-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)-beta-D-glucopyranosyl]-2-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)-D-galactitol
0.00388
chlorobiphenyl desleucyl vancomycin
0.0015
chlorobiphenyl vancomycin
0.000006 - 0.019
moenomycin A
0.000033
moenomycin disaccharide
0.000016
moenomycin trisaccharide
0.00038 - 0.00101
Vancomycin
0.0497
4-[3-amino-3-([1,1'-biphenyl]-4-yl)propanamido]-1,5-anhydro-2,4-dideoxy-3-O-[2-deoxy-2-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)-beta-D-glucopyranosyl]-2-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)-D-galactitol
Escherichia coli
-
pH 7.5, 25°C, PBP1b
0.0732
4-[3-amino-3-([1,1'-biphenyl]-4-yl)propanamido]-1,5-anhydro-2,4-dideoxy-3-O-[2-deoxy-2-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)-beta-D-glucopyranosyl]-2-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)-D-galactitol
Staphylococcus aureus
-
pH 7.5, 25°C, MGT
0.0062
ACL19098
Escherichia coli
-
pH 7.5, 25°C
0.0062
ACL19098
Escherichia coli
-
pH 7.5, 25°C, PBP1b
0.0073
ACL19098
Staphylococcus aureus
-
pH 8.0, 20°C
0.0073
ACL19098
Staphylococcus aureus
-
pH 7.5, 25°C, MGT
0.0346
ACL19109
Escherichia coli
-
pH 7.5, 25°C
0.0346
ACL19109
Escherichia coli
-
pH 7.5, 25°C, PBP1b
0.0382
ACL19109
Staphylococcus aureus
-
pH 8.0, 20°C
0.0382
ACL19109
Staphylococcus aureus
-
pH 7.5, 25°C, MGT
0.0365
ACL19110
Escherichia coli
-
pH 7.5, 25°C
0.0365
ACL19110
Escherichia coli
-
pH 7.5, 25°C, PBP1b
0.0905
ACL19110
Staphylococcus aureus
-
pH 8.0, 20°C
0.0905
ACL19110
Staphylococcus aureus
-
pH 7.5, 25°C, MGT
0.0497
ACL19243
Escherichia coli
-
pH 7.5, 25°C
0.0732
ACL19243
Staphylococcus aureus
-
pH 8.0, 20°C
0.04
ACL19273
Escherichia coli
-
pH 7.5, 25°C
0.04
ACL19273
Escherichia coli
-
pH 7.5, 25°C, PBP1b
0.05
ACL19273
Staphylococcus aureus
-
pH 8.0, 20°C
0.05
ACL19273
Staphylococcus aureus
-
pH 7.5, 25°C, MGT
0.0362
ACL19336
Escherichia coli
-
pH 7.5, 25°C
0.0362
ACL19336
Escherichia coli
-
pH 7.5, 25°C, PBP1b
0.075
ACL19336
Staphylococcus aureus
-
pH 8.0, 20°C
0.075
ACL19336
Staphylococcus aureus
-
pH 7.5, 25°C, MGT
0.00388
chlorobiphenyl desleucyl vancomycin
Escherichia coli
-
-
0.00388
chlorobiphenyl desleucyl vancomycin
Aquifex aeolicus
-
-
0.0015
chlorobiphenyl vancomycin
Escherichia coli
-
-
0.0015
chlorobiphenyl vancomycin
Aquifex aeolicus
-
-
0.000006
moenomycin A
Escherichia coli
-
-
0.000006
moenomycin A
Aquifex aeolicus
-
-
0.000006
moenomycin A
Staphylococcus aureus
-
recombinant wild-type enzyme, pH and temperature not specified in the publication
0.0000076
moenomycin A
Staphylococcus aureus
-
pH 8.0, 20°C
0.000075
moenomycin A
Staphylococcus aureus
-
recombinant enzyme mutant Y181W, pH and temperature not specified in the publication
0.019
moenomycin A
Escherichia coli
-
pH 7.5, 25°C
0.000033
moenomycin disaccharide
Escherichia coli
-
-
0.000033
moenomycin disaccharide
Aquifex aeolicus
-
-
0.000016
moenomycin trisaccharide
Escherichia coli
-
-
0.000016
moenomycin trisaccharide
Aquifex aeolicus
-
-
0.00038
Vancomycin
Escherichia coli
-
-
0.00038
Vancomycin
Aquifex aeolicus
-
-
0.00054
Vancomycin
Escherichia coli
-
pH 7.5, 25°C
0.000685
Vancomycin
Staphylococcus aureus
-
pH 8.0, 20°C
0.00101
Vancomycin
Escherichia coli
pH and temperature not specified in the publication, recombinant enzyme