2.4.1.131: GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

This is an abbreviated version!
For detailed information about GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.131

2.4.1.131

lipid-linked

n-glycosylation

n-linked

glycosyltransferase

dolichol-linked

asparagine-linked

man5glcnac2-pp-dolichol

alpha1,2-linked

single-subunit

oligosaccharyltransferase

man5glcnac2-pp-dol

microcephaly

Reaction

2 GDP-alpha-D-mannose +

alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol

= 2 GDP +

alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol

Synonyms

Alg11, Alg2 mannosyltransferase, At2G40190, galactomannan deficiency protein 3, GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase, GDP-mannose-oligosaccharide-lipid mannosyltransferase, gmd3, guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase, hALG11, LEW3, mannosyltransferase, guanosine diphosphomannose-oligosaccharide-lipid, oligosaccharide-lipid mannosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.131 GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

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Results	in table
2	Activating Compound
3418	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
16	Disease/ Diagnostics
5	General Information
17	Inhibitors
4	KM Value [mM]
13	Localization
4	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
16	Organism
6	Pathway
6	PDB ID
5	pH Optimum
1	Posttranslational Modification
27	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
15	Reference
13	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
27	Substrates and Products (Substrate)
2	Subunits
18	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 2.4.1.131 - GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

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ADP

Oryctolagus cuniculus

2 mM, less than 15% inhibition

638568

ATP

Oryctolagus cuniculus

2 mM, less than 15% inhibition

Ca2+

weak

Cu2+

strong

deoxycholate

Oryctolagus cuniculus

638568

GDP

Oryctolagus cuniculus

0.02 mM, 84% inhibition; 2 mM, 84% inhibition

638568

GMP

Oryctolagus cuniculus

0.02 mM, 30% inhibition; 2 mM, 30% inhibition

638568

GTP

Oryctolagus cuniculus

0.02 mM, 40% inhibition; 2 mM, 40% inhibition

638568

Mn2+

Bos taurus

638571

taurocholate

Oryctolagus cuniculus

638568

UDP

Oryctolagus cuniculus

2 mM, less than 15% inhibition

638568

UDP-galactose

Oryctolagus cuniculus

2 mM, less than 15% inhibition

638568

UDP-glucose

Oryctolagus cuniculus

2 mM, less than 15% inhibition

638568

UDP-N-acetylglucosamine

Oryctolagus cuniculus

2 mM, less than 15% inhibition

638568

additional information

3 entries