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2.4.1.133: xylosylprotein 4-beta-galactosyltransferase

This is an abbreviated version!
For detailed information about xylosylprotein 4-beta-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.133

Reaction

UDP-alpha-D-galactose
+
[protein]-3-O-(beta-D-xylosyl)-L-serine
=
UDP
 +
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine

Synonyms

B4GALT7, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 7, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase-I, beta-1,4-galactosyltransferase-T7, beta-1,4-GalT, beta-1,4-GalT 7, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase VII, beta1,4-galactosyltransferase-7, beta1,4-GalT, beta1,4-GalT-I, beta1,4-GalT7, beta4-galactosyltransferase 7, beta4Gal-T7, beta4galactosyltransferase I, beta4GalT-7, beta4GalT7, dbeta4GalTI, galactosyltransferase I, galactosyltransferase, uridine diphosphogalactose-xylose, GalT I, GalT-I, hbeta4GalT7, MgGalT7, pNP-xylose-beta-1,4-galactosyltransferase, proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I, SQV-3, UDP-D-galactose:D-xylose galactosyltransferase, UDP-D-galactose:xylose galactosyltransferase, UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase, UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase, xylosylprotein 4-beta-galactosyltransferase, xylosylprotein beta1,4-galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.133 xylosylprotein 4-beta-galactosyltransferase

Inhibitors

Inhibitors on EC 2.4.1.133 - xylosylprotein 4-beta-galactosyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,4-diamino-2,3-dicyano-1,4-bis-(2-aminophenylthio)butadiene
-
0-10 microM of specific inhibitor U0126 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide
2-(6-hydroxynaphthyl) beta-D-xylopyranoside
-
-
3-acetamido-propyl beta-D-xylopyranoside
-
-
3-benzamido-propyl beta-D-xylopyranoside
-
-
3-hexanamido-propyl beta-D-xylopyranoside
-
-
4-methylumbelliferyl 4-deoxy-beta-D-fluoroxylose
-
4-methylumbelliferyl 4-deoxy-beta-D-xylopyranoside
-
4-methylumbelliferyl 4-deoxy-beta-D-xyloside
-
4-methylumbelliferyl 4-fluoro-beta-D-xylopyranoside
50% inhibition at 2 mM. The strategic position of Tyr194 forming stacking interactions with the aglycone, and the hydrogen bond between the His195 nitrogen backbone and the carbonyl group of the coumarinyl molecule to develop a tight binder of the enzyme. This leads to the synthesis of 4-deoxy-4-fluoroxylose linked to 4-methylumbelliferone that inhibits enzyme activity in vitro with a Ki 10 times lower than the Km value and efficiently impairs glycosaminoglycan synthesis in a cell assay
4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol
-
10-30 microM of specific inhibitor SB202190 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide
cycloheximide
-
first order kinetics
N-[O-(beta-D-xylopyranosyl)-3-hydroxypropyl]phthalamate
-
-
N-[O-(beta-D-xylopyranosyl)-3-hydroxypropyl]succinamate
-
-
naphthyl 4-deoxy-beta-D-xylopyranoside
slight inhibition
O-gamma-beta-D-xylopyranosyl-N-Cbz-L-serine methyl ester
-
-
pyrazolanthrone
-
10-50 microM of specific inhibitor SP600125 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide
UDP-mannose
-
UDP-N-acetylgalactosamine
-
additional information
not inhibited by naphthyl 4-deoxy-beta-D-xylopyranoside; structure-guided design of enzyme inhibitors, xyloside inhibitors design and in vitro and in cellulo competition assays, overview
-